Generic Name: Amrinone Brand Name(s): Generics only. No brands available.

Uses

What is amrinone used for?

Amrinone is commonly used for treating congestive heart failure. It belongs to a group of drugs called cardiac inotropic agents, which help the heart increase its ability to beat. It also relaxes the blood vessels so the heart does not have to pump as hard.

How should I take amrinone?

This medication is available in an injectable form to be given directly into a vein (IV) by a healthcare professional.

How do I store amrinone?

Amrinone is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store amrinone in the bathroom or the freezer. There may be different brands of amrinone that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush amrinone down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using amrinone?

Before using this drug, tell your doctor if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with any of active or inactive ingredients of amrinone or other medications.
  • You have any other illnesses, disorders, or medical conditions.
  • You have hypersensitivity to inamrinone, milrinone and bisulfites.

Patients using this drug should be cautioned in case of:

  • Recent MI
  • Electrolyte abnormalities
  • Hypotension
  • Pro-arrhythmic effects
  • Insufficient cardiac filling pressure
  • Severe aortic or pulmonic valvular disease
  • Renal impairment
  • Concurrent use of disopyramide (may cause hypotension)

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using amrinone during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking amrinone. Amrinone is pregnancy risk category C, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from amrinone?

Side effects may occur when using this drug, such as:

  • Arrhythmia
  • Thrombocytopenia
  • Nausea
  • Hypotension
  • Fever
  • Vomiting
  • Abdominal pain
  • Anorexia
  • Chest pain
  • Injections site pain
  • Hepatotoxicity

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with amrinone?

Amrinone may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with amrinone?

Amrinone may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with amrinone?

Amrinone may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using amrinone.

What is the dose of amrinone for an adult?

Load: 0.75 mg/kg IV bolus over 2-3 minutes, then 5-10 mcg/kg/min IV.

Total daily dose (including loading dose) should not exceed 10 mg/kg/day.

Therapeutic dosage range: 0.5-7 mcg/Ml.

What is the dose of amrinone for a child?

<28 days old

Load as in adults, 0.75 mg/kg IV over 3-5 minutes, then 3-5 mcg/kg/min IV maintenance infusion.

Bolus dose may need to be repeated after 30 minutes.

Total daily dose should not exceed 10 mg/kg/day.

Therapeutic dosage range: 0.5-7 mcg/mL

>28 days old

Load as in adults, 0.75 mg/kg IV over 3-5 minutes, then 5-15 mcg/kg/min IV.

Not to exceed 10 mg/kg/day.

Therapeutic dosage range: 0.5-7 mcg/mL.

How is amrinone available?

Amrinone is available in the following dosage forms and strengths:

  • Injectable solution: 5mg/mL

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of amrinone, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: October 6, 2017 | Last Modified: October 6, 2017

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