Generic Name: Amprenavir Brand Name(s): Generics only. No brands available.


What is amprenavir used for?

Amprenavir is commonly used for treating HIV infection. Amprenavir is used in combination with other medicines.

Amprenavir is an HIV-protease inhibitor. It works by inhibiting the growth of HIV.

How should I take amprenavir?

Use amprenavir as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Amprenavir may be taken with or without food. If you take it with food, do not take it with a high fat meal.

Amprenavir comes with an additional patient leaflet. Read it carefully and reread it each time you get amprenavir refilled.

Do not take antacids or a buffered form of didanosine within 1 hour before or 1 hour after taking amprenavir.

Continue to use amprenavir even if you feel well. Do not miss any doses.

Do not switch between the capsule and liquid forms of amprenavir. They are not equal milligram to milligram. Consult with your doctor or pharmacist.

How do I store amprenavir?

Amprenavir is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store amprenavir in the bathroom or the freezer. There may be different brands of amprenavir that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush amprenavir down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using amprenavir?

Before using this drug, tell your doctor if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with any of active or inactive ingredients of amprenavir or other medications.
  • You have any other illnesses, disorders, or medical conditions.
  • You are taking astemizole, cisapride, delavirdine, an ergot derivative (e.g., ergotamine), eletriptan, erythromycin, certain HMG-CoA reductase inhibitors (lovastatin, simvastatin), midazolam, nevirapine, an oral contraceptive (birth control pills), pimozide, a quinazoline (e.g., alfuzosin), rifampin, St. John’s wort, sumatriptan, terfenadine, or triazolam.

Amprenavir is not a cure for HIV infection and patients may continue to acquire illnesses and infections associated with HIV. Remain under the care of your doctor.

Amprenavir may not prevent other infections. If your health changes, check with your doctor.

When your medicine supply begins to run low, get more from your doctor or pharmacist as soon as possible. The virus may develop resistance to amprenavir and become more difficult to treat if you stop taking it, even for a short period of time.

Amprenavir offers no protection from the transmission of HIV to others through sexual contact or blood contamination. Use barrier forms of contraception (e.g., condoms) if you are infected with HIV. Do not share needles, other injection equipment, or personal items such as toothbrushes or razor blades.

Certain birth control pills may decrease the effectiveness of amprenavir. Women should not take birth control pills and should use additional or other birth control measures (e.g., condoms, diaphragms) while taking amprenavir.

Do not take vitamin E supplements while you are taking amprenavir. Amprenavir already contains vitamin E.

Amprenavir may cause high blood sugar (e.g., thirst, increased urination, confusion, drowsiness, flushing, rapid breathing, fruity breath odor). If these symptoms occur, tell your doctor immediately.

Changes in body fat may occur in some patients taking this type of medicine. These changes may include increased amount of fat in the upper back and neck, breast, and around the trunk, and loss of fat from the legs, arms, and face. The cause and long-term effects are unknown. Discuss any concerns with your doctor.

Lab tests, including liver function, blood cholesterol or triglyceride levels, and white blood cell counts, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.

Use amprenavir with caution in the elderly because they may be more sensitive to its effects.

Amprenavir is not recommended for use in children younger than 4 years of age. Safety and effectiveness in this age group have not been confirmed.

Is it safe during pregnancy or breastfeeding?

There isn’t enough information about the safety of using amprenavir during pregnancy and breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking amprenavir.

Side effects

What side effects can occur from amprenavir?

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most common side effects persist or become bothersome:

  • Diarrhea/loose stools
  • Headache
  • Nausea
  • Numbness or tingling around the mouth and in the hands and feet
  • Rash
  • Shift of body fat to stomach and upper back
  • Stomach pain
  • Taste disorders
  • Vomiting

Seek medical attention right away if any of these severe side effects occur:

  • Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue)
  • Change in mood, emotions, or behavior
  • Clumsiness
  • Depression
  • Excessive urination, thirst, or hunger
  • Fever, chills, or sore throat
  • Muscle pain or stiffness
  • Red, swollen, or blistered skin
  • Seizures
  • Unusual tiredness or weakness
  • Yellowing of the skin or eyes

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.


What drugs may interact with amprenavir?

Amprenavir may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Products that may interact with this drug are:

  • Carbamazepine, dexamethasone, methadone, non-nucleoside reverse transcriptase inhibitors (NNRTIs) (e.g., efavirenz, nevirapine), oral contraceptives (birth control pills), phenobarbital, phenytoin, rifampin, saquinavir, or St. John’s wort because the effectiveness of amprenavir may be decreased.
  • HIV protease inhibitors (e.g., indinavir, ritonavir) because the actions and side effects of amprenavir may be increased.
  • Astemizole, certain HMG-CoA reductase inhibitors (e.g., lovastatin, simvastatin), cisapride, eletriptan, ergot derivatives (e.g., ergotamine), erythromycin, midazolam, pimozide, quinazolines (e.g., alfuzosin), sumatriptan, terfenadine, or triazolam because the risk of side effects may be increased by amprenavir.
  • Aldosterone blockers (e.g., eplerenone), antiarrhythmics (e.g., amiodarone, bepridil, flecainide, lidocaine, propafenone, quinidine), azole antifungals (e.g., itraconazole, ketoconazole), benzodiazepines (e.g., alprazolam), calcium channel blockers (e.g., diltiazem, amlodipine), fluoxetine, fluticasone, immunosuppressants (e.g., cyclosporine, tacrolimus), muscarinic receptor antagonists (e.g., darifenacin), narcotic analgesics (e.g., fentanyl), rifabutin, sildenafil, trazodone, or tricyclic antidepressants (e.g., amitriptyline) because the risk of side effects may be increased by amprenavir.
  • Delavirdine because effectiveness may be decreased by amprenavir.
  • Anticoagulants (e.g., warfarin) because actions and effectiveness may be altered by amprenavir.

Does food or alcohol interact with amprenavir?

Amprenavir may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with amprenavir?

Amprenavir may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Health conditions that may interact with this drug are:

  • A severe allergic reaction (e.g., severe rash, hives, difficulty breathing, dizziness) to any other sulfonamide medicine, such as acetazolamide, celecoxib, certain diuretics (e.g., hydrochlorothiazide), glyburide, probenecid, sulfamethoxazole, valdecoxib, or zonisamide
  • Diabetes
  • Hemophilia or other bleeding disorders
  • High cholesterol or triglyceride levels
  • High blood sugar
  • Liver disease
  • A skin rash
  • Kidney problems


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using amprenavir.

What is the dose of amprenavir for an adult?

Usual Adult Dose for HIV Infection

Capsules: 1200 mg orally twice a day

Oral solution: 1400 mg (93 mL) orally twice a day

What is the dose of amprenavir for a child?

Usual Pediatric Dose for HIV Infection

Oral capsule formulation:

  • 4 to 12 years or 13 to 16 years and less than 50 kg: 20 mg/kg orally twice a day or 15 mg/kg three times a day, not to exceed 2400 mg/day
  • 13 to 16 years and 50 kg or more: 1200 mg orally twice a day

Oral solution formulation:

  • 4 to 12 years or 13 to 16 years and less than 50 kg: 22.5 mg/kg (1.5 mL/kg) orally twice a day or 17 mg/kg (1.1 mL/kg) three times a day, not to exceed 2800 mg/day
  • 13 to 16 years and 50 kg or more: 1400 mg (93 mL) orally twice a day

How is amprenavir available?

Amprenavir is available in the following dosage forms and strengths:

  • Capsule
  • Oral solution

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of amprenavir, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Review Date: October 6, 2017 | Last Modified: October 6, 2017

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