Ampicillin and sulbactam

By Medically reviewed by hellodoktor

Generic Name: Ampicillin and sulbactam Brand Name(s): Ampicillin and sulbactam.

Know the basics

What are ampicillin and sulbactam used for?

Ampicillin and Sulbactam combination is used to treat bacterial infections in many different parts of the body.

How should I take ampicillin and sulbactam?

Injectable

  • Your doctor will prescribe your dose and tell you how often it should be given. This medicine is given as a shot into a muscle or through a needle placed into a vein.
  • A nurse or other health provider will give you this medicine.

How do I store ampicillin and sulbactam?

Ampicillin and sulbactam are best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store ampicillin and sulbactam in the bathroom or the freezer. There may be different brands of ampicillin and sulbactam that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush ampicillin and sulbactam down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Know the precautions & warnings

What should I know before using ampicillin and sulbactam?

Before using ampicillin and sulbactam, tell your doctor if you have:

  • Allergic reaction: to ampicillin and sulbactam, excipients using for dosage form containing ampicillin and sulbactam. The information is detailed in the leaflet.
  • Allergic reaction to any other medicines, foods, dyes, preservatives, or animals.
  • Pediatric.
  • Geriatric.
  • Used any other health conditions, drugs that have a risk of interaction with ampicillin and sulbactam.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using ampicillin and sulbactam during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking ampicillin and sulbactam. Ampicillin and sulbactam are pregnancy risk category B, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk;
  • B=No risk in some studies;
  • C=There may be some risk;
  • D=Positive evidence of risk;
  • X=Contraindicated;
  • N=Unknown.

Know the side effects

What side effects can occur from ampicillin and sulbactam?

As taking others medicines, taking ampicillin and sulbactam can cause some side effects. Most of them are rarely occurring and do not need any supplementary treatment. However, it is always important for you to consult your doctor if you have any problem after taking this medicine.

Some of the side effects are listed below:

  • Bleeding;
  • Blistering;
  • Burning;
  • Coldness;
  • Discoloration of the skin;
  • Feeling of pressure;
  • Hives;
  • Infection;
  • Inflammation;
  • Itching;
  • Lumps;
  • Numbness;
  • Pain;
  • Rash;
  • Redness;
  • Scarring;
  • Soreness;
  • Stinging;
  • Swelling;
  • Tenderness;
  • Tingling;
  • Ulceration;
  • Warmth at the injection site.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Know the interactions

What drugs may interact with ampicillin and sulbactam?

Ampicillin and sulbactam may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval, such as allopurinol or probenecid.

Does food or alcohol interact with ampicillin and sulbactam?

Ampicillin and sulbactam may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with ampicillin and sulbactam?

Ampicillin and sulbactam may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have, especially:

  • Diarrhea;
  • Kidney disease;
  • Liver disease;
  • Mononucleosis.

Understand the dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using ampicillin and sulbactam.

What is the dose of ampicillin and sulbactam for an adult?

Consult your doctor for information about the dose of ampicillin and sulbactam hydrochloride.

Recommended doses in some cases are listed below:

For gynecological Infections: 1.5g (1g ampicillin + 0.5g sulbactam) to 3g (2g ampicillin + 1g sulbactam) administered intravenously or intramuscularly every 6 hours.

For intra-Abdominal Infections: 1.5g (1g ampicillin + 0.5g sulbactam) to 3g (2g ampicillin + 1g sulbactam) administered intravenously or intramuscularly every 6 hours.

For skin & skin structure infections: 1.5g (1g ampicillin + 0.5g sulbactam) to 3g (2g ampicillin + 1g sulbactam) administered intravenously or intramuscularly every 6 hours .

For renal Impairment:

  • For patient with Creatinin Clearance of 15-29 ml/min: administered every 12 hours.
  • For patient with Creatinin Clearance of 5-14 ml/min: administered every 24 hours.

What is the dose of ampicillin and sulbactam for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How are ampicillin and sulbactam available?

Ampicillin and sulbactam are available in the following dosage forms and strengths:

  • Powder for Solution 750 mg, 1500 mg.

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services (115) or go to your nearest emergency room.

What should I do if I miss a dose?

You must use this medicine on a fixed schedule. Call your doctor or pharmacist if you miss a dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: October 5, 2016 | Last Modified: September 12, 2019

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