Ampicillin

By

Generic Name: Ampicillin Brand Name(s): Generics only. No brands available. Avability: Rx Pregnancy Category: B

Uses

What is Ampicillin used for?

Ampicillin is used to treat a wide variety of bacterial infections. It is a penicillin-type antibiotic. It works by stopping the growth of bacteria.

How should I take Ampicillin?

Take this medication by mouth usually 4 times a day (every 6 hours), or as directed by your doctor. Take ampicillin on an empty stomach (1 hour before or 2 hours after a meal) with a full glass of water. Drink plenty of fluids while using this medication unless your doctor tells you otherwise.

The dosage is based on your medical condition and response to therapy.

For the best effect, take this antibiotic at evenly spaced times. To help you remember, take this medication at the same time(s) every day.

Continue to take this medication until the full-prescribed amount is finished even if symptoms disappear after a few days. Stopping the medication too early may allow bacteria to continue to grow, which may result in a relapse of the infection.

Inform your doctor if your condition persists or worsens.

How do I store Ampicillin?

Ampicillin is best stored at room temperature away from direct light and moisture.  The reconstituted oral suspension should be stored in a refrigerator; any unused portion should be discarded after 14 days.

To prevent drug damage, you should not store Ampicillin in the bathroom or the freezer. There may be different brands of Ampicillin that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Ampicillin down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Ampicillin?

Before taking ampicillin, tell your doctor or pharmacist if you are allergic to it; or to penicillin or cephalosporin antibiotics; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, a certain type of viral infection (infectious mononucleosis).

Ampicillin may cause live bacterial vaccines (such as typhoid vaccine) to not work as well. Do not have any immunizations/vaccinations while using this medication unless your doctor tells you to.

Kidney function declines as you grow older. This medication is removed by the kidneys. Therefore, elderly people may be more sensitive to this drug.

This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor.

Ampicillin passes into breast milk. Consult your doctor before breast-feeding.

Is it safe during pregnancy or breast-feeding?

There are no adequate studies in women for determining risk when using this Ampicillin during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Ampicillin. Ampicillin is pregnancy risk category B according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown

Side effects

What side effects can occur from Ampicillin?

Nausea, vomiting, diarrhea, or mouth/tongue sores may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

Tell your doctor right away if any of these rare but very serious side effects occur: dark urine, persistent nausea or vomiting, stomach/abdominal pain, yellowing eyes or skin, easy bruising or bleeding, persistent sore throat or fever.

This medication may rarely cause a severe intestinal condition (Clostridium difficile-associated diarrhea) due to a type of resistant bacteria. This condition may occur during treatment or weeks to months after treatment has stopped. Do not use anti-diarrhea products or narcotic pain medications if you have any of the following symptoms because these products may make them worse. Tell your doctor right away if you develop: persistent diarrhea, abdominal or stomach pain/cramping, blood/mucus in your stool.

Use of this medication for prolonged or repeated periods may result in oral thrush or a new vaginal yeast infection (oral or vaginal fungal infection). Contact your doctor if you notice white patches in your mouth, a change in vaginal discharge or other new symptoms.

A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Ampicillin can commonly cause a mild rash that is usually not serious. However, you may not be able to tell it apart from a rare rash that could be a sign of a severe allergic reaction. Therefore, seek immediate medical attention if you develop any rash.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Ampicillin?

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: methotrexate, tetracyclines.

Although most antibiotics are unlikely to affect hormonal birth control such as pills, patch, or ring, a few antibiotics (such as rifampin, rifabutin) can decrease their effectiveness. This could result in pregnancy. If you use hormonal birth control, ask your doctor or pharmacist for more details.

Ampicillin may cause false positive results with certain diabetic urine testing products (cupric sulfate-type). This drug may also affect the results of certain lab tests. Make sure laboratory personnel and your doctors know you use this drug.

Ampicillin may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Ampicillin?

Ampicillin may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Ampicillin?

Ampicillin may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this Ampicillin.

What is the dose of Ampicillin for an adult?

Usual Adult Dose for Bacterial Infection

The manufacturer recommends:

Parenteral:

-Infections of the respiratory tract and soft tissues: 250 to 500 mg IM or IV every 6 hours

-Infections of the gastrointestinal and genitourinary tracts (including Neisseria gonorrhoeae infections in females): 500 mg IM or IV every 6 hours

-Urethritis in males due to N gonorrhoeae: 500 mg IM or IV every 8 to 12 hours for 2 doses

-Bacterial meningitis: 150 to 200 mg/kg/day in equally divided doses every 3 to 4 hours; may start with IV drip therapy and continue with IM injections

-Septicemia: 150 to 200 mg/kg/day; start with IV administration for at least 3 days and continue with IM route every 3 to 4 hours

Oral:

-Genitourinary or gastrointestinal tract infections (other than gonorrhea): 500 mg orally every 6 hours

-Gonorrhea: 3.5 g orally as a single dose (plus probenecid 1 g)

-Respiratory tract infections: 250 mg orally every 6 hours

Approved indications:

-Parenteral: Respiratory tract infections, bacterial meningitis, septicemia, endocarditis, urinary tract infections, gastrointestinal infections

-Oral: Genitourinary tract infections (including gonorrhea), respiratory tract infections, gastrointestinal tract infections, and meningitis

Some experts recommend:

Parenteral: 1 to 2 g IM or IV every 4 to 6 hours or 50 to 250 mg/kg/day IM or IV in divided doses

Maximum dose: 12 g/day

Oral: 250 to 500 mg orally every 6 hours

Usual Adult Dose for Endocarditis

The manufacturer gives no specific dosing instructions.

Approved indications:

-Parenteral: Endocarditis due to susceptible gram-positive organisms including Streptococcus species, penicillin G-susceptible staphylococci, and enterococci

American Heart Association (AHA) recommendations for patients with normal renal function:

Native valve or prosthetic valve infections due to susceptible enterococci: Ampicillin 2 g IV every 4 hours plus gentamicin or streptomycin (if gentamicin resistant)

Duration of therapy:

-Native valve: 4 weeks (symptoms for less than 3 months) or 6 weeks (symptoms for at least 3 months)

-Prosthetic valve: At least 6 weeks

Native valve or prosthetic valve infections due to Enterococcus faecalis strains resistant to penicillin, aminoglycoside, and vancomycin: Ampicillin 2 g IV every 4 hours plus imipenem-cilastatin or ceftriaxone

Duration of therapy: At least 8 weeks

Infections due to susceptible strains of Escherichia coli or Proteus mirabilis: Ampicillin 2 g IV every 4 hours plus an aminoglycoside (usually gentamicin)

Usual Adult Dose for Bacterial Endocarditis Prophylaxis

(Not approved by FDA)

AHA recommendations: 2 g IM or IV as a single dose 30 to 60 minutes before procedure

Usual Adult Dose for Meningitis

The manufacturer recommends: 150 to 200 mg/kg/day IV in equally divided doses every 3 to 4 hours

Approved indications:

-Parenteral: Bacterial meningitis due to E coli, group B streptococci, and other gram-negative bacteria (Listeria monocytogenes, N meningitidis)

-Oral: Meningitis due to N meningitidis

Some experts recommend:

IV: 200 mg/kg/day IV in equally divided doses every 4 hours, in combination with other parenteral antibiotics

Maximum dose: 12 g/day

Intrathecal or intraventricular: 10 to 50 mg/day in addition to IV antibiotics

Usual Adult Dose for Septicemia

The manufacturer recommends: 150 to 200 mg/kg/day

Comments:

Approved indications:

-Parenteral: Septicemia due to susceptible gram-positive organisms including Streptococcus species, penicillin G-susceptible staphylococci, and enterococci; gram-negative sepsis due to E coli, P mirabilis, and Salmonella species

Some experts recommend: 1 to 2 g IV every 3 to 4 hours, in combination with other antibiotics

Usual Adult Dose for Gastroenteritis

The manufacturer recommends: 500 mg orally or IM or IV every 6 hours

Approved indications:

-Parenteral: Gastrointestinal infections due to Salmonella species (including S typhi) and Shigella species

-Oral: Gastrointestinal tract infections due to Shigella, Salmonella species (including S typhi), E coli, P mirabilis, and enterococci

Some experts recommend: 250 to 500 mg orally every 6 hours

Usual Adult Dose for Intraabdominal Infection

The manufacturer recommends: 500 mg orally or IM or IV every 6 hours

Approved indications:

-Parenteral: Gastrointestinal infections due to Salmonella species (including S typhi) and Shigella species

-Oral: Gastrointestinal tract infections due to Shigella, Salmonella species (including S typhi), E coli, P mirabilis, and enterococci

Some experts recommend: 1 to 2 g IV every 4 to 6 hours in combination with other antibiotics, depending on the nature and severity of the infection

Duration of therapy: 10 to 14 days

Usual Adult Dose for Skin or Soft Tissue Infection

The manufacturer recommends: 250 to 500 mg IM or IV every 6 hours

Some experts recommend: 250 to 500 mg orally every 6 hours or 1 to 2 g IV every 4 to 6 hours, depending on the nature and severity of the infection

Usual Adult Dose for Pharyngitis

The manufacturer recommends:

Parenteral: 250 to 500 mg IM or IV every 6 hours

Oral: 250 mg orally every 6 hours

Approved indications:

Parenteral: Respiratory tract infections due to Streptococcus pneumoniae, Staphylococcus aureus, Haemophilus influenzae, and Group A beta-hemolytic streptococci

Oral: Respiratory tract infections due to nonpenicillinase-producing H influenzae and staphylococci, and streptococci (including S pneumoniae)

Some experts recommend: 500 mg orally or 1 to 2 g IM or IV every 6 hours, depending on the nature and severity of the infection

Usual Adult Dose for Sinusitis

The manufacturer recommends:

Parenteral: 250 to 500 mg IM or IV every 6 hours

Oral: 250 mg orally every 6 hours

Approved indications:

Parenteral: Respiratory tract infections due to Streptococcus pneumoniae, Staphylococcus aureus, Haemophilus influenzae, and Group A beta-hemolytic streptococci

Oral: Respiratory tract infections due to nonpenicillinase-producing H influenzae and staphylococci, and streptococci (including S pneumoniae)

Some experts recommend: 500 mg orally or 1 to 2 g IM or IV every 6 hours, depending on the nature and severity of the infection

Usual Adult Dose for Upper Respiratory Tract Infection

The manufacturer recommends:

Parenteral: 250 to 500 mg IM or IV every 6 hours

Oral: 250 mg orally every 6 hours

Approved indications:

Parenteral: Respiratory tract infections due to Streptococcus pneumoniae, Staphylococcus aureus, Haemophilus influenzae, and Group A beta-hemolytic streptococci

Oral: Respiratory tract infections due to nonpenicillinase-producing H influenzae and staphylococci, and streptococci (including S pneumoniae)

Some experts recommend: 500 mg orally or 1 to 2 g IM or IV every 6 hours, depending on the nature and severity of the infection

Usual Adult Dose for Pneumonia

The manufacturer recommends:

Parenteral: 250 to 500 mg IM or IV every 6 hours

Oral: 250 mg orally every 6 hours

Approved indications:

Parenteral: Respiratory tract infections due to S pneumoniae, S aureus, H influenzae, and Group A beta-hemolytic streptococci

Oral: Respiratory tract infections due to nonpenicillinase-producing H influenzae and staphylococci, and streptococci (including S pneumoniae)

Some experts recommend:

Beta-lactamase negative, penicillin-susceptible: 1 to 2 g IV every 4 to 6 hours, in combination with other antibiotic(s) depending on the nature and severity of the infection

Usual Adult Dose for Bronchitis

The manufacturer recommends:

Parenteral: 250 to 500 mg IM or IV every 6 hours

Oral: 250 mg orally every 6 hours

Approved indications:

Parenteral: Respiratory tract infections due to S pneumoniae, S aureus, H influenzae, and Group A beta-hemolytic streptococci

Oral: Respiratory tract infections due to nonpenicillinase-producing H influenzae and staphylococci, and streptococci (including S pneumoniae)

Some experts recommend:

Bacterial exacerbations of chronic bronchitis: 250 to 500 mg orally every 6 hours for 5 to 10 days, depending on the nature and severity of the infection

Usual Adult Dose for Urinary Tract Infection

The manufacturer recommends: 500 mg orally or IM or IV every 6 hours

Comments:

-Severe, chronic, or stubborn infections may require larger doses.

Approved indications:

-Parenteral: Urinary tract infections due to sensitive strains of E coli and P mirabilis

-Oral: Genitourinary tract infections due to E coli, P mirabilis, enterococci, Shigella, Salmonella species (including S typhi)

Some experts recommend:

Mild, uncomplicated: 250 to 500 mg orally every 6 hours

Severe, complicated: 500 mg to 2 g IV every 4 to 6 hours with or without other antibiotics, depending on the nature and severity of the infection

Usual Adult Dose for Pyelonephritis

The manufacturer recommends: 500 mg orally or IM or IV every 6 hours

Some experts recommend: 500 mg to 2 g IM or IV every 4 to 6 hours with or without other antibiotics, depending on the nature and severity of the infection

Duration of therapy: 2 to 3 weeks

Usual Adult Dose for Shigellosis

The manufacturer recommends: 500 mg orally or IM or IV every 6 hours

Approved indications: Gastrointestinal tract infections due to Shigella species

Some experts recommend: 500 mg orally every 6 hours for 5 days

Usual Adult Dose for Typhoid Fever

The manufacturer recommends: 500 mg orally or IM or IV every 6 hours

Approved indications: Gastrointestinal tract infections due to Salmonella species (including S typhi)

Some experts recommend:

Severe, fully susceptible: 25 mg/kg IM or IV every 6 hours for 10 to 14 days

Carrier state: 1.5 g orally or IV with probenecid 500 mg every 6 hours for 6 weeks

Usual Adult Dose for Prevention of Perinatal Group B Streptococcal Disease

(Not approved by FDA)

Centers for Disease Control and Prevention (CDC) recommendations: 2 g IV initial dose, then 1 g IV every 4 hours until delivery

Usual Adult Dose for Surgical Prophylaxis

(Not approved by FDA)

Liver transplant: Ampicillin 1 g IV plus cefotaxime 1 g IV at induction of anesthesia, then every 6 hours during procedure and for 48 hours after final surgical closure

Usual Adult Dose for Leptospirosis

(Not approved by FDA)

Some experts recommend:

Mild: 500 to 750 mg orally every 6 hours

Moderate to severe: 0.5 to 1 g IV every 6 hours

Usual Adult Dose for Peritonitis

(Not approved by FDA)

Some experts recommend:

CAPD-associated peritonitis: 250 to 500 mg orally twice a day and/or 100 to 125 mg/L exchange intraperitoneally, with or without other antibiotics depending on the nature and severity of the infection

Secondary: 1 to 2 g IV every 4 to 6 hours in combination with other antibiotics, depending on the nature and severity of the infection

Duration of therapy: 10 to 14 days

Usual Adult Dose for Otitis Media

(Not approved by FDA)

Some experts recommend: 500 mg orally or 1 to 2 g IM or IV every 6 hours, depending on the nature and severity of the infection

Renal Dose Adjustments

Dose adjustment(s) may be required; however, no specific guidelines have been suggested by the manufacturer.

Some experts recommend:

Adults:

CrCl 10 to 50 mL/min: Usual dose every 6 to 12 hours

CrCl less than 10 mL/min: Usual dose every 12 to 24 hours

Liver Dose Adjustments

No adjustment required.

Dose Adjustments

The manufacturer states that larger doses may be required for severe or chronic infections; this applies to all patients, irrespective of age and weight.

What is the dose of Ampicillin for a child?

Usual Pediatric Dose for Bacterial Infection

American Academy of Pediatrics (AAP) General Dosing Recommendations for Susceptible Infections:

Neonates:

7 days or less, 2000 g or less: 50 mg/kg IM or IV every 12 hours

7 days or less, greater than 2000 g: 50 mg/kg IM or IV every 8 hours

8 to 28 days, 2000 g or less: 50 mg/kg IM or IV every 8 hours

8 to 28 days, greater than 2000 g: 50 mg/kg IM or IV every 6 hours

1 month or older:

Mild to moderate infections:

Parenteral: 25 to 37.5 mg/kg IM or IV every 6 hours

Oral: 12.5 to 25 mg/kg orally every 6 hours

Maximum dose: 4 g/day

Severe infections: 50 to 100 mg/kg IM or IV every 6 hours

Maximum dose: 12 g/day

The manufacturer recommends:

Parenteral:

-Infections of the respiratory tract and soft tissues:

Less than 40 kg: 25 to 50 mg/kg/day IM or IV in equally divided doses every 6 to 8 hours

40 kg or more: 250 to 500 mg IM or IV every 6 hours

-Infections of the gastrointestinal and genitourinary tracts (including N gonorrhoeae infections in females):

Less than 40 kg: 50 mg/kg/day IM or IV in equally divided doses every 6 to 8 hours

40 kg or more: 500 mg IM or IV every 6 hours

-Bacterial meningitis:

Children: 150 to 200 mg/kg/day in equally divided doses every 3 to 4 hours; may start with IV drip therapy and continue with IM injections

-Septicemia:

Children: 150 to 200 mg/kg/day; start with IV administration for at least 3 days and continue with IM route every 3 to 4 hours

Oral:

-Genitourinary or gastrointestinal tract infections:

20 kg or less: 25 mg/kg orally every 6 hours

Greater than 20 kg: 500 mg orally every 6 hours

-Respiratory tract infections:

20 kg or less: 50 mg/kg/day orally in equally divided doses every 6 to 8 hours

Greater than 20 kg: 250 mg orally every 6 hours

Approved indications:

-Parenteral: Respiratory tract Infections, bacterial meningitis, septicemia, endocarditis, urinary tract infections, gastrointestinal infections

-Oral: Genitourinary tract infections (including gonorrhea), respiratory tract infections, gastrointestinal tract infections, and meningitis

Usual Pediatric Dose for Bacteremia

AAP Recommendations:

Group B streptococcal bacteremia (presumed or proven):

Neonates:

7 days or younger, 2000 g or less: 100 mg/kg IM or IV every 12 hours

7 days or younger, greater than 2000 g: 50 mg/kg IM or IV every 8 hours or 100 mg/kg IM or IV every 12 hours

8 to 28 days, 2000 g or less: 50 mg/kg IM or IV every 8 hours

8 to 28 days, greater than 2000 g: 50 mg/kg IM or IV every 6 hours

Duration of therapy: At least 10 days for treatment of bacteremia without defined focus

The manufacturer recommends:

Children: 150 to 200 mg/kg/day

Approved indications:

-Parenteral: Septicemia due to susceptible gram-positive organisms including Streptococcus species, penicillin G-susceptible staphylococci, and enterococci; gram-negative sepsis due to E coli, P mirabilis, and Salmonella species

Usual Pediatric Dose for Septicemia

AAP Recommendations:

Group B streptococcal bacteremia (presumed or proven):

Neonates:

7 days or younger, 2000 g or less: 100 mg/kg IM or IV every 12 hours

7 days or younger, greater than 2000 g: 50 mg/kg IM or IV every 8 hours or 100 mg/kg IM or IV every 12 hours

8 to 28 days, 2000 g or less: 50 mg/kg IM or IV every 8 hours

8 to 28 days, greater than 2000 g: 50 mg/kg IM or IV every 6 hours

Duration of therapy: At least 10 days for treatment of bacteremia without defined focus

The Manufacturer Recommends:

Children: 150 to 200 mg/kg/day

Approved indications:

-Parenteral: Septicemia due to susceptible gram-positive organisms including Streptococcus species, penicillin G-susceptible staphylococci, and enterococci; gram-negative sepsis due to E coli, P mirabilis, and Salmonella species

Usual Pediatric Dose for Meningitis

AAP Recommendations:

Neonates:

Group B streptococcal meningitis:

7 days or younger: 50 to 100 mg/kg IV every 8 hours; some experts recommend 75 mg/kg IV every 6 hours

Older than 7 days: 50 to 75 mg/kg IV every 6 hours

Duration of therapy: At least 14 days (if uncomplicated)

Infants, children, adolescents: 50 to 100 mg/kg IV every 6 hours

Maximum dose: 12 g/day

The Manufacturer Recommends:

Children: 150 to 200 mg/kg/day IV in equally divided doses every 3 to 4 hours

Usual Pediatric Dose for Endocarditis

The manufacturer gives no specific dosing instructions.

Approved indications:

-Parenteral: Endocarditis due to susceptible gram-positive organisms including Streptococcus species, penicillin G-susceptible staphylococci, and enterococci

AHA Recommendations for Patients with Normal Renal Function (dosage should not exceed adult dose):

Native valve or prosthetic valve infections due to susceptible enterococci: Ampicillin 300 mg/kg/day IV in equally divided doses every 4 to 6 hours plus gentamicin or streptomycin (if gentamicin resistant)

Maximum dose: 12 g/day

Duration of therapy:

-Native valve: 4 weeks (symptoms for less than 3 months) or 6 weeks (symptoms for at least 3 months)

-Prosthetic valve: At least 6 weeks

Native valve or prosthetic valve infections due to E faecalis strains resistant to penicillin, aminoglycoside, and vancomycin: Ampicillin 300 mg/kg/day IV in equally divided doses every 4 to 6 hours plus imipenem-cilastatin or ceftriaxone

Duration of therapy: At least 8 weeks

Usual Pediatric Dose for Bacterial Endocarditis Prophylaxis

(Not approved by FDA)

AHA Recommendations:

Children: 50 mg/kg IM or IV as a single dose 30 to 60 minutes before procedure

Comments:

-Recommended for patients unable to take oral medication.

-Antibiotic prophylaxis may be used for dental procedures (involving manipulation of gingival tissues or periapical region of teeth or perforation of oral mucosa), respiratory tract procedures, or procedures on infected skin, skin structures, or musculoskeletal tissue only for patients with the highest risk of infective endocarditis.

Usual Pediatric Dose for Upper Respiratory Tract Infection

AAP general dosing recommendations for susceptible infections:

Neonates:

7 days or less, 2000 g or less: 50 mg/kg IM or IV every 12 hours

7 days or less, greater than 2000 g: 50 mg/kg IM or IV every 8 hours

8 to 28 days, 2000 g or less: 50 mg/kg IM or IV every 8 hours

8 to 28 days, greater than 2000 g: 50 mg/kg IM or IV every 6 hours

1 month or older:

Mild to moderate infections:

Parenteral: 25 to 37.5 mg/kg IM or IV every 6 hours

Oral: 12.5 to 25 mg/kg orally every 6 hours

Maximum dose: 4 g/day

Severe infections: 50 to 100 mg/kg IM or IV every 6 hours

Maximum dose: 12 g/day

The manufacturer recommends:

Parenteral:

Less than 40 kg: 25 to 50 mg/kg/day IM or IV in equally divided doses every 6 to 8 hours

40 kg or more: 250 to 500 mg IM or IV every 6 hours

Oral:

20 kg or less: 50 mg/kg/day orally in equally divided doses every 6 to 8 hours

Greater than 20 kg: 250 mg orally every 6 hours

Approved indications:

-Parenteral: Respiratory tract infections due to S pneumoniae, S aureus (penicillinase and nonpenicillinase-producing), H influenzae, and group A beta-hemolytic streptococci

-Oral: Respiratory tract infections due to nonpenicillinase-producing H influenzae and staphylococci, and streptococci (including S pneumoniae)

Usual Pediatric Dose for Pneumonia

AAP general dosing recommendations for susceptible infections:

Neonates:

7 days or less, 2000 g or less: 50 mg/kg IM or IV every 12 hours

7 days or less, greater than 2000 g: 50 mg/kg IM or IV every 8 hours

8 to 28 days, 2000 g or less: 50 mg/kg IM or IV every 8 hours

8 to 28 days, greater than 2000 g: 50 mg/kg IM or IV every 6 hours

1 month or older:

Mild to moderate infections:

Parenteral: 25 to 37.5 mg/kg IM or IV every 6 hours

Oral: 12.5 to 25 mg/kg orally every 6 hours

Maximum dose: 4 g/day

Severe infections: 50 to 100 mg/kg IM or IV every 6 hours

Maximum dose: 12 g/day

Infectious Diseases Society of America (IDSA) and Pediatric Infectious Diseases Society (PIDS) Recommendations:

Community-acquired pneumonia:

Older than 3 months:

Empiric therapy, S pneumoniae (MICs for penicillin 2 mcg/mL or greater), or H influenzae (beta-lactamase negative) in fully immunized patients: 37.5 to 50 mg/kg IV every 6 hours

Group A Streptococcus: 50 mg/kg IV every 6 hours

S pneumoniae resistant to penicillin (MICs 4 mcg/mL or greater): 75 to 100 mg/kg IV every 6 hours; recommended as alternate therapy

The manufacturer recommends:

Parenteral:

Less than 40 kg: 25 to 50 mg/kg/day IM or IV in equally divided doses every 6 to 8 hours

40 kg or more: 250 to 500 mg IM or IV every 6 hours

Oral:

20 kg or less: 50 mg/kg/day orally in equally divided doses every 6 to 8 hours

Greater than 20 kg: 250 mg orally every 6 hours

Approved indications:

-Parenteral: Respiratory tract infections due to S pneumoniae, S aureus (penicillinase and nonpenicillinase-producing), H influenzae, and group A beta-hemolytic streptococci

-Oral: Respiratory tract infections due to nonpenicillinase-producing H influenzae and staphylococci, and streptococci (including S pneumoniae)

Usual Pediatric Dose for Skin or Soft Tissue Infection

AAP general dosing recommendations for susceptible infections:

Neonates:

7 days or less, 2000 g or less: 50 mg/kg IM or IV every 12 hours

7 days or less, greater than 2000 g: 50 mg/kg IM or IV every 8 hours

8 to 28 days, 2000 g or less: 50 mg/kg IM or IV every 8 hours

8 to 28 days, greater than 2000 g: 50 mg/kg IM or IV every 6 hours

1 month or older:

Mild to moderate infections:

Parenteral: 25 to 37.5 mg/kg IM or IV every 6 hours

Oral: 12.5 to 25 mg/kg orally every 6 hours

Maximum dose: 4 g/day

Severe infections: 50 to 100 mg/kg IM or IV every 6 hours

Maximum dose: 12 g/day

The manufacturer recommends:

Parenteral:

Less than 40 kg: 25 to 50 mg/kg/day IM or IV in equally divided doses every 6 to 8 hours

40 kg or more: 250 to 500 mg IM or IV every 6 hours

Usual Pediatric Dose for Urinary Tract Infection

AAP general dosing recommendations for susceptible infections:

Neonates:

7 days or less, 2000 g or less: 50 mg/kg IM or IV every 12 hours

7 days or less, greater than 2000 g: 50 mg/kg IM or IV every 8 hours

8 to 28 days, 2000 g or less: 50 mg/kg IM or IV every 8 hours

8 to 28 days, greater than 2000 g: 50 mg/kg IM or IV every 6 hours

1 month or older:

Mild to moderate infections:

Parenteral: 25 to 37.5 mg/kg IM or IV every 6 hours

Oral: 12.5 to 25 mg/kg orally every 6 hours

Maximum dose: 4 g/day

Severe infections: 50 to 100 mg/kg IM or IV every 6 hours

Maximum dose: 12 g/day

The manufacturer recommends:

Parenteral:

Less than 40 kg: 50 mg/kg/day IM or IV in equally divided doses every 6 to 8 hours

40 kg or more: 500 mg IM or IV every 6 hours

Oral:

20 kg or less: 25 mg/kg orally every 6 hours

Greater than 20 kg: 500 mg orally every 6 hours

Approved indications:

-Parenteral: Urinary tract infections due to sensitive strains of E coli and P mirabilis

-Oral: Genitourinary tract infections due to E coli, P mirabilis, enterococci, Shigella, Salmonella species (including S typhi)

Usual Pediatric Dose for Surgical Prophylaxis

(Not approved by FDA)

Some experts recommend:

Liver transplant:

1 month or older: Ampicillin 50 mg/kg IV plus cefotaxime 50 mg/kg IV at induction of anesthesia and every 6 hours for 48 hours after final surgical closure

How is Ampicillin available?

Ampicillin is available in the following dosage forms and strengths:

  • Oral capsule,
  • Oral powder for reconstitution,
  • Injectable powder for injection,
  • Compounding powder.

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Ampicillin, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

 

Sources

Review Date: November 20, 2018 | Last Modified: November 20, 2018

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