Amphetamine

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Generic Name: Amphetamine Brand Name(s): Generics only. No brands available.

Uses

What is amphetamine used for?

Amphetamine is commonly used for treat attention deficit hyperactivity disorder (ADHD). It works by changing the amounts of certain natural substances in the brain.

Amphetamine belongs to a class of drugs known as stimulants which affect chemicals in the brain and nerves that contribute to hyperactivity and impulse control. It can help increase your ability to pay attention, stay focused on an activity, and control behavior problems. It may also help you to organize your tasks and improve listening skills.

How should I take amphetamine?

Take this medication by mouth with or without food as directed by your doctor, usually once daily in the morning. Taking this medication after noon may cause trouble sleeping (insomnia).

Amphetamine may be addictive. Never share amphetamine with another person, especially someone with a history of drug abuse or addiction. Selling or distributing this medicine is illegal.

Using amphetamine improperly can cause death or serious side effects on the heart.

Shake the oral suspension (liquid) well just before you measure a dose. Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.

To take the orally disintegrating tablet:

  • Keep the tablet in its blister pack until you are ready to take it. Open the package and peel back the foil. Do not push a tablet through the foil or you may damage the tablet.
  • Use dry hands to remove the tablet and place it in your mouth.
  • Do not swallow the tablet whole. Allow it to dissolve in your mouth without chewing. If desired, you may drink liquid to help swallow the dissolved tablet.

While using amphetamine, your doctor will need to check your progress at regular visits. Your heart rate, blood pressure, height and weight may also need to be checked often.

Amphetamine can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using this medicine.

How do I store amphetamine?

Amphetamine is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store amphetamine in the bathroom or the freezer. There may be different brands of amphetamine that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush amphetamine down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using amphetamine?

Before using this drug, tell your doctor if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with any of active or inactive ingredients of amphetamine or other medications.
  • You have any other illnesses, disorders, or medical conditions.

You should not use amphetamine if you have:

  • Moderate to severe high blood pressure
  • Overactive thyroid
  • Severe anxiety, tension, or agitation (stimulant medicine can make these symptoms worse)
  • A history of drug or alcohol addiction

Some stimulants have caused sudden death in certain people. Tell your doctor if you have:

  • Heart problems or a congenital heart defect
  • High blood pressure
  • A family history of heart disease or sudden death

Do not use amphetamine if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using this medication during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking this medication. This medication is pregnancy risk category C, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from amphetamine?

Common side effects may include:

  • Stomach pain, nausea, vomiting, loss of appetite
  • Diarrhea, constipation
  • Weight loss
  • Mood changes, feeling restless or nervous, sleep problems (insomnia)
  • Dry mouth, unusual or unpleasant taste in the mouth
  • Runny nose, nosebleeds
  • Increased heart rate
  • Headache, dizziness
  • Itching
  • Impotence, sexual problems

Stop using amphetamine and call your doctor immediately if you have:

  • Chest pain, trouble breathing, feeling like you might pass out
  • Fast heartbeats, rapid breathing
  • Confusion, unusual thoughts, paranoia, hallucination
  • New behavior problems, aggression, anger, feeling irritable
  • Numbness, pain, cold feeling, unexplained wounds, or skin color changes (pale, red, or blue appearance) in your fingers or toes
  • Changes in your vision
  • Unexplained muscle pain, tenderness, or weakness (especially if you also have fever, unusual tiredness, and dark colored urine)
  • High levels of serotonin in the body: agitation, hallucinations, fever, fast heart rate, overactive reflexes, nausea, vomiting, diarrhea, loss of coordination, fainting

Get emergency medical help if you have signs of an allergic reaction to amphetamine: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Amphetamine can affect growth in children. Tell your doctor if your child is not growing at a normal rate while using this medicine.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with amphetamine?

Amphetamine may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Taking MAO inhibitors with this medication may cause a serious and possibly deadly drug interaction. During treatment with amphetamine, avoid taking MAO inhibitors:

  • Isocarboxazid
  • Linezolid
  • Methylene blue
  • Moclobemide
  • Phenelzine
  • Procarbazine
  • Rasagiline
  • Selegiline
  • Tranylcypromine

Does food or alcohol interact with amphetamine?

Amphetamine may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with amphetamine?

Amphetamine may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Health conditions that may interact with this drug are:

  • Cardiovascular
  • Glaucoma
  • Agitation
  • Cardiac Disease
  • Glaucoma
  • Hypertension
  • Liver Disease
  • Seizure Disorders
  • Substance Abuse
  • Psychiatric Disorders
  • Renal Dysfunction
  • Tics
  • Diabetics

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this medication.

What is the dose of amphetamine for an adult?

For Narcolepsy:

Immediate-release oral tablet:

  • Initial Dose: 10 mg orally per day in divided doses
  • Maintenance Dose: Daily dose may be raised in 10 mg increments at weekly intervals until optimal response is obtained

For Obesity:

Immediate-release oral tablet:

  • Initial Dose: 5 mg orally 30 to 60 minutes before each meal
  • Maximum Dose: 30 mg orally per day in divided doses
  • Duration of Therapy: Should not exceed a few weeks

What is the dose of amphetamine for a child?

For Narcolepsy:

Immediate-release oral tablet:

Age 6 to 11 Years:

  • Initial Dose: 5 mg orally per day in divided doses
  • Maintenance Dose: Daily dose may be raised in 5 mg increments at weekly intervals until optimal response is obtained.

Age 12 Years and Older:

  • Initial Dose: 10 mg orally per day in divided doses
  • Maintenance Dose: Daily dose may be raised in 10 mg increments at weekly intervals until optimal response is obtained.

For Obesity:

Immediate-release oral tablet:

Age 12 Years and Older:

  • Initial Dose: 5 mg orally 30 to 60 minutes before each meal
  • Maximum Dose: 30 mg orally per day in divided doses
  • Duration of Therapy: Should not exceed a few weeks

For Attention Deficit Disorder:

Immediate-release oral tablets:

Age 3 to 5 Years:

  • Initial Dose: 2.5 mg orally per day
  • Maintenance Dose: Daily dose may be raised in 2.5 mg increments at weekly intervals until optimal response is obtained.

Age 6 to 17 Years:

  • Initial Dose: 5 mg orally 1 or 2 times a day
  • Maintenance Dose: Daily dose may be raised in 5 mg increments at weekly intervals until optimal response is obtained.
  • Maximum Dose: Only in rare cases will it be necessary to exceed 40 mg per day.

Extended-release oral suspension:

Age 6 to 17 Years:

  • Initial Dose: 2.5 or 5 mg orally once a day in the morning
  • Maintenance Dose: Dose may be raised in increments of 2.5 to 10 mg per day every 4 to 7 days until optimal response is obtained.
  • Maximum Dose: 20 mg orally per day

How is amphetamine available?

Amphetamine is available in the following strengths:

  • Tablet 5 mg; 10 mg; 2.5 mg/mL; 3.1 mg; 6.3 mg; 9.4 mg; 12.5 mg; 15.7 mg; 18.8 mg

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of amphetamine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Review Date: August 4, 2017 | Last Modified: September 2, 2017

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