Generic Name: Amoxicillin + clavulanate Brand Name(s): Generics only. No brands available.

Uses

What are amoxicillin and clavulanate used for?

Amoxicillin and clavulanate are commonly used for treating a wide variety of bacterial infections such as sinusitis, pneumonia, ear infections, bronchitis, urinary tract infections, and infections of the skin. It works by stopping the growth of bacteria. This antibiotic only treats bacterial infections. It will not work for viral infections (e.g., common cold, flu).

Amoxicillin and clavulanate may be prescribed for other uses; ask your doctor or pharmacist for more information.

How should I take amoxicillin and clavulanate?

Please take this medicine exactly as directed by your doctor.

Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

You may take this medicine with or without meals. However, it is best to take this medicine at the start of a meal or snack to avoid an upset stomach.

Swallow the extended-release tablet whole. Do not crush, break, or chew it.

If you are using the chewable tablets, chew the tablet completely before swallow.

There are certain flavors that can be mixed with the oral suspension to make it taste better.

Shake the oral liquid well before measuring the dose. Use a dosing spoon or medicine dropper to measure the dose.

How do I store amoxicillin and clavulanate?

Amoxicillin and clavulanate are best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store amoxicillin and clavulanate in the bathroom or the freezer. There may be different brands of amoxicillin and clavulanate that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush amoxicillin and clavulanate down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using amoxicillin and clavulanate?

Consult with your doctor or pharmacist, if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with any of active or inactive ingredients of amoxicillin and clavulanate or other medications.
  • You have any other illnesses, disorders, or medical conditions.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using this medication during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking this medication. This medication is pregnancy risk category B, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from amoxicillin and clavulanate?

Amoxicillin and clavulanate may cause following side effects, such as:

  • Mild diarrhea, gas, stomach pain
  • Nausea or vomiting
  • Headache
  • Skin rash or itching
  • White patches in your mouth or throat
  • Vaginal yeast infection (itching or discharge)

If you experience any of the following symptoms, call your doctor immediately:

  • Severe skin rash
  • Itching
  • Hives
  • Difficulty breathing or swallowing
  • Wheezing
  • Vaginal itching and discharge
  • Yellowing of the skin or eyes

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with amoxicillin and clavulanate?

Amoxicillin and clavulanate may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Some products that may interact with this drug include:

  • Probenecid: Taking probenecid with amoxicillin and clavulanate may result in increased and prolonged blood concentrations of amoxicillin.
  • Oral Anticoagulants: Adjustments in the dose of oral anticoagulants may be necessary to maintain the desired level of anticoagulation.
  • Allopurinol: Taking allopurinol and amoxicillin increases the incidence of rashes in patients receiving both drugs as compared to patients receiving amoxicillin alone. It is not known whether this potentiation of amoxicillin rashes is due to allopurinol or the hyperuricemia present in these patients.
  • Oral Contraceptives: Amoxicillin and clavulanate may affect intestinal flora, leading to lower estrogen reabsorption and reduced efficacy of combined oral estrogen/progesterone contraceptives.

Does food or alcohol interact with amoxicillin and clavulanate?

Amoxicillin and clavulanate may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with amoxicillin and clavulanate?

Amoxicillin and clavulanate may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

These health conditions are:

  • Liver disease (including liver problems caused by previous use of amoxicillin/clavulanic acid)
  • Kidney disease (such as requiring dialysis)
  • A certain type of viral infection (infectious mononucleosis)

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this medication.

What is the dose of amoxicillin and clavulanate for an adult?

For oral dosage forms (chewable tablets or suspension):

Adults, teenagers, and children weighing 40 kilograms (kg) or more: the recommended dose is 250 to 500 milligrams (mg) every 8 hours, or 500 to 875 mg every 12 hours.

For oral dosage form (extended-release tablets):

Adults: the recommended dose is 2000 milligrams (mg) every 12 hours.

For oral dosage form (tablets):

Adults, teenagers, and children weighing 40 kilograms (kg) or more: the recommended dose is 250 to 500 milligrams (mg) every 8 hours, or 500 to 875 mg every 12 hours.

What is the dose of amoxicillin and clavulanate for a child?

For oral dosage forms (chewable tablets or suspension):

Children 3 months of age and older and weighing less than 40 kilograms (kg): Dose is based on body weight and must be determined by your doctor. The dose is usually 20 to 40 mg per kg of body weight per day, divided and given every 8 hours, or 25 to 45 mg per kg of body weight per day divided and given every 12 hours.

Children younger than 3 months of age: Dose is based on body weight and must be determined by your doctor. The dose is usually 30 mg per kg of body weight per day, divided and given every 12 hours.

For oral dosage form (extended-release tablets):

Children: Use and dose must be determined by your doctor.

For oral dosage form (tablets):

Children weighing less than 40 kg: Use and dose must be determined by your doctor.

How are amoxicillin and clavulanate available?

Amoxicillin and clavulanate is available in the following dosage forms and strengths:

Oral Suspension

  • (125mg/31.25mg)/5mL
  • (200mg/28.5mg)/5mL
  • (250mg/62.5mg)/5mL
  • (400mg/57mg)/5mL
  • (600mg/42.9mg)/5mL

Tablet

  • 250mg/125mg
  • 500mg/125mg
  • 875mg/125mg

Tablet, Extended Release

  • 1000mg/62.5mg

Tablet, Chewable

  • 200mg/28.5mg
  • 400mg/57mg

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of medication, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: May 25, 2017 | Last Modified: May 25, 2017

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