By Medically reviewed by hellodoktor

Generic Name: Amoxapine Brand Name(s): Generics only. No brands available.


What is amoxapine used for?

Amoxapine is commonly used to treat low mood (depression).

It may be given to you for other reasons. Talk with the doctor.

How should I take amoxapine?

Use amoxapine as ordered by your doctor. Read all information given to you. Follow all instructions closely.

Take at bedtime if you are taking once a day.

To gain the most benefit, do not miss doses.

Keep taking this medicine as you have been told by your doctor or other health care provider, even if you feel well.

How do I store amoxapine?

Amoxapine is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store amoxapine in the bathroom or the freezer. There may be different brands of amoxapine that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush amoxapine down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using amoxapine?

Before using this drug, tell your doctor if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with any of active or inactive ingredients of amoxapine or other medications.
  • You have any other illnesses, disorders, or medical conditions.
  • You have had a recent heart attack.
  • You have taken certain drugs used for low mood (depression) like isocarboxazid, phenelzine, or tranylcypromine or drugs used for Parkinson’s disease like selegiline or rasagiline in the last 14 days. Taking amoxapine within 14 days of those drugs can cause very bad high blood pressure.
  • You are taking any of these drugs: Linezolid or methylene blue.

Tell all of your health care providers that you take this medicine. This includes your doctors, nurses, pharmacists, and dentists.

Avoid driving and doing other tasks or actions that call for you to be alert until you see how amoxapine affects you.

Do not stop taking this medicine all of a sudden without calling your doctor. You may have a greater risk of side effects. If you need to stop amoxapine, you will want to slowly stop it as ordered by your doctor.

Talk with your doctor before you drink alcohol or use other drugs and natural products that slow your actions.

Be careful in hot weather or while being active. Drink lots of fluids to stop fluid loss.

Some people may have a higher chance of eye problems with this medicine. Your doctor may want you to have an eye exam to see if you have a higher chance of these eye problems. Call your doctor right away if you have eye pain, change in eyesight, or swelling or redness in or around the eye.

If you are 65 or older, use amoxapine with care. You could have more side effects.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using amoxapine during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking amoxapine. Amoxapine is pregnancy risk category C, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from amoxapine?

Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat
  • Weakness on 1 side of the body, trouble speaking or thinking, change in balance, drooping on one side of the face, or blurred eyesight
  • Chest pain or pressure or a fast heartbeat
  • A heartbeat that does not feel normal
  • Feeling confused
  • Trouble passing urine
  • Feeling very tired or weak
  • Seizures
  • Anxiety
  • Shakiness
  • Fever
  • Enlarged breasts
  • Nipple discharge
  • Change in sex ability
  • For women, no period
  • Trouble controlling body movements, twitching, change in balance, trouble swallowing or speaking

Some people who take amoxapine may get a very bad muscle problem called tardive dyskinesia. The risk may be greater in older adults, mainly women. The chance that this will happen or that it will never go away is greater in people who take this medicine in higher doses or for a long time. Muscle problems may also occur after short-term use with low doses. Call your doctor right away if you have trouble controlling body movements or if you have muscle problems with your tongue, face, mouth, or jaw like tongue sticking out, puffing cheeks, mouth puckering, or chewing.

A very bad and sometimes deadly health problem called neuroleptic malignant syndrome (NMS) may happen. Call your doctor right away if you have any fever, muscle cramps or stiffness, dizziness, very bad headache, confusion, change in thinking, fast heartbeat, heartbeat that does not feel normal, or are sweating a lot.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.


What drugs may interact with amoxapine?

Amoxapine may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with amoxapine?

Amoxapine may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with amoxapine?

Amoxapine may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using amoxapine.

What is the dose of amoxapine for an adult?

Usual Adult Dose for Depression

Initial dose: 50 mg orally two or three times a day

Maintenance dose: 100 mg orally two or three times a day

Maximum dose: 600 mg orally per day

Usual Geriatric Dose for Depression

Initial dose: 25 mg orally two or three times a day

Maintenance dose: 50 mg orally two or three times a day

Maximum dose: 300 mg orally per day

What is the dose of amoxapine for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is amoxapine available?

Amoxapine is available in the following dosage forms and strengths:

  • Tablet

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of amoxapine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Review Date: October 5, 2017 | Last Modified: September 11, 2019

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