Generic Name: Amlodipine-Atorvastatin Brand Name(s): Generics only. No brands available. Avability: Rx Pregnancy Category: N

Uses

What is Amlodipine-Atorvastatin used for?

Amlodipine-Atorvastatin is a combination medication. Amlodipine is a calcium channel blocker and is used to treat high blood pressure or prevent chest pain (angina). It works by relaxing the blood vessels so that blood can flow more easily and the heart does not need to work so hard. Atorvastatin is used along with a proper diet to help lower “bad” cholesterol and fats (such as LDL, triglycerides) and raise “good” cholesterol (HDL) in the blood. It belongs to a group of drugs known as “statins.” It works by reducing the amount of cholesterol made by the liver. Lowering “bad” cholesterol and triglycerides and raising “good” cholesterol decreases the risk of heart disease and helps prevent strokes and heart attacks.

How should I take Amlodipine-Atorvastatin?

Take this medication by mouth with or without food as directed by your doctor, usually once daily.

The dosage is based on your medical condition, response to treatment, age, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

If you also take certain other drugs to lower your cholesterol (bile acid-binding resins such as cholestyramine or colestipol), take this product at least 1 hour before or at least 4 hours after taking these medications. These products can react with atorvastatin, preventing its full absorption.

Take this medication regularly in order to get the most benefit from it. Remember to take it at the same time each day. It may take up to 2 weeks before you get the full benefit of amlodipine, and up to 4 weeks before you get the full benefit of atorvastatin.

It is important to continue taking this medication even if you feel well. Most people with high blood pressure or high cholesterol/triglycerides do not feel sick.

If this product is used for chest pain, it must be taken regularly to be effective. It should not be used to treat chest pain when it occurs. Use other medications (such as nitroglycerin placed under the tongue) to relieve chest pain as directed by your doctor.

Tell your doctor if your condition does not improve or if it worsens (such as your blood pressure readings remain high or increase, your chest pain occurs more often).

How do I store Amlodipine-Atorvastatin?

Amlodipine-Atorvastatin is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Amlodipine-Atorvastatin in the bathroom or the freezer. There may be different brands of Amlodipine-Atorvastatin that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Amlodipine-Atorvastatin down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

 

Precautions & warnings

What should I know before using Amlodipine-Atorvastatin?

Before taking this product, tell your doctor or pharmacist if you are allergic to amlodipine or atorvastatin; or to other calcium channel blockers (such as nifedipine); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, kidney disease, alcohol use, certain structural heart problems (aortic/mitral stenosis).

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

To reduce your risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.

Older adults may be more sensitive to the side effects of the drug, especially muscle problems and dizziness.

This product must not be used during pregnancy. Atorvastatin may harm an unborn baby. Therefore, it is important to prevent pregnancy while taking this medication. Consult your doctor for more details and to discuss the use of reliable forms of birth control (such as condoms, birth control pills) while taking this medication. If you become pregnant or think you may be pregnant, tell your doctor right away.

Amlodipine passes into breast milk. It is unknown if atorvastatin passes into breast milk. Because of the possible risk to the infant, breast-feeding while using this product is not recommended. Consult your doctor before breast-feeding.

Is it safe during pregnancy or breast-feeding?

There are no adequate studies in women for determining risk when using this Amlodipine-Atorvastatin during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Amlodipine-Atorvastatin. Amlodipine-Atorvastatin is pregnancy risk category N according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown

Side effects

What side effects can occur from Amlodipine-Atorvastatin?

Dizziness or lightheadedness may occur as your body adjusts to the medication. Swelling hands/ankles/feet, tiredness, or flushing may also occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

A very small number of people taking atorvastatin may have mild memory problems or confusion. If these rare effects occur, talk to your doctor.

Rarely, statins may cause or worsen diabetes. Talk to your doctor about the benefits and risks.

Tell your doctor right away if any of these unlikely but serious side effects occur: fainting, fast/pounding heartbeat.

This drug may rarely cause muscle problems (which can rarely lead to very serious conditions called rhabdomyolysis and autoimmune myopathy). Tell your doctor right away if you develop any of these symptoms during treatment and if these symptoms persist after your doctor stops this drug: muscle pain/tenderness/weakness (especially with fever or unusual tiredness), signs of kidney problems (such as change in the amount of urine).

This medication may rarely cause liver problems. If you notice any of the following rare but serious side effects, tell your doctor right away: yellowing eyes/skin, dark urine, severe stomach/abdominal pain, persistent nausea/vomiting.

Although this medication is effective in preventing chest pain (angina), some people who already have severe heart disease may rarely develop worsening chest pain or a heart attack after starting this medication or increasing the dose. Get medical help right away if you experience: worsening chest pain, symptoms of a heart attack (such as chest/jaw/left arm pain, shortness of breath, unusual sweating).

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Amlodipine-Atorvastatin?

Some products that may interact with this drug include: gemfibrozil, telaprevir, ritonavir.

Other medications can affect the removal of atorvastatin from your body, which may affect how atorvastatin works. Examples include colchicine, saquinavir, telithromycin, certain azole antifungals (such as itraconazole, ketoconazole, posaconazole), among others.

Some products have ingredients that could raise your blood pressure. Tell your pharmacist what products you are using, and ask how to use them safely (especially cough-and-cold products, diet aids, or NSAIDs such as ibuprofen/naproxen).

Amlodipine-Atorvastatin may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Amlodipine-Atorvastatin?

Amlodipine-Atorvastatin may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

Avoid eating grapefruit or drinking grapefruit juice while using this medication unless your doctor instructs you otherwise. Grapefruit can increase the amount of this medication in your bloodstream. Consult your doctor or pharmacist for more details.

This drug may make you dizzy. Alcohol or marijuana can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Talk to your doctor if you are using marijuana.

Limit alcoholic beverages. Daily use of alcohol may increase your risk for liver problems, especially when combined with atorvastatin. Ask your doctor or pharmacist for more information.

Do not take any red yeast rice products while you are taking amlodipine/atorvastatin because some red yeast rice products may also contain a statin called lovastatin. Taking amlodipine/atorvastatin and red yeast rice products together can increase your risk of serious muscle and liver problems.

What health conditions may interact with Amlodipine-Atorvastatin?

Amlodipine-Atorvastatin may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

 

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this Amlodipine-Atorvastatin.

What is the dose of Amlodipine-Atorvastatin for an adult?

Usual Adult Dose for Hyperlipidemia

Initial dose: Amlodipine 5 mg-Atorvastatin 10 to 20 mg orally once a day

Maximum dose: Amlodipine 10 mg-Atorvastatin 80 mg orally once a day

Usual Adult Dose for Hypertension

Initial dose: Amlodipine 5 mg-Atorvastatin 10 to 20 mg orally once a day

Maximum dose: Amlodipine 10 mg-Atorvastatin 80 mg orally once a day

Usual Adult Dose for Angina Pectoris

Initial dose: Amlodipine 5 mg-Atorvastatin 10 to 20 mg orally once a day

Maximum dose: Amlodipine 10 mg-Atorvastatin 80 mg orally once a day

Usual Adult Dose for Coronary Artery Disease

Initial dose: Amlodipine 5 mg-Atorvastatin 10 to 20 mg orally once a day

Maximum dose: Amlodipine 10 mg-Atorvastatin 80 mg orally once a day

Usual Adult Dose for Prevention of Cardiovascular Disease

Initial dose: Amlodipine 5 mg-Atorvastatin 10 to 20 mg orally once a day

Maximum dose: Amlodipine 10 mg-Atorvastatin 80 mg orally once a day

-Small adult, fragile, or elderly patients may be started on amlodipine 2.5 mg orally once a day.

-Most coronary artery disease patients will require amlodipine 10 mg orally once a day for adequate effect.

-Patients who require greater than 45% low-density lipoprotein (LDL) reduction may be started on atorvastatin 40 mg orally once a day.

-May be titrated for amlodipine after 1 to 2 weeks and for atorvastatin after 2 to 4 weeks.

-Atorvastatin has not been studied in conditions where the major lipoprotein abnormality is elevation of chylomicrons (Fredrickson types I and V).

Renal Dose Adjustments

No adjustment recommended

Liver Dose Adjustments

Contraindicated

What is the dose of Amlodipine-Atorvastatin for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Amlodipine-Atorvastatin available?

Amlodipine-Atorvastatin is available in the following dosage forms and strengths:

  • Oral tablet.

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Amlodipine-Atorvastatin, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

 

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: November 8, 2018 | Last Modified: November 8, 2018

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