Generic Name: Amitiza Brand Name(s): Generics only. No brands available.


What is Amitiza® (lubiprostone) used for?

Amitiza® increases the secretion of fluid in your intestines to help make it easier to pass stools (bowel movements).

Amitiza® is used to treat chronic constipation, or constipation caused by opioid (narcotic) pain medicine. It may also be used to treat irritable bowel syndrome in women with constipation as the main symptom.

Amitiza® is for use only in adults.

How should I take Amitiza® (lubiprostone)?

Amitiza® is usually taken twice daily. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Take Amitiza® with food or milk. Drink a full glass of water when you take this medication. Do not crush, chew, break, or open a capsule. Swallow it whole.

You may have tightness in your chest or feel short of breath within 1 hour after taking Amitiza®. This side effect should go away within 3 hours, but it may occur again when you take your next dose. Talk with your doctor if this side effect becomes bothersome.

Do not take Amitiza® if you have severe diarrhea. Call your doctor for instructions.

How do I store Amitiza® (lubiprostone)?

Amitiza® is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Amitiza® in the bathroom or the freezer. There may be different brands of Amitiza® that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Amitiza® down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Amitiza® (lubiprostone)?

Before using this drug, tell your doctor if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with any of active or inactive ingredients of Amitiza® or other medications.
  • You have any other illnesses, disorders, or medical conditions.

You should not use Amitiza® if you have a blockage in your digestive tract, or if you have severe diarrhea.

To make sure Amitiza® is safe for you, tell your doctor if you have any other cause for obstruction in your gastrointestinal (digestive) system, such as:

  • Gallstones
  • Crohn’s disease
  • Hirschsprung’s disease
  • Impacted bowel movement
  • Diverticulitis, polyps
  • A history of hernia
  • Liver disease

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using Amitiza® during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Amitiza®. Amitiza® is pregnancy risk category C, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from Amitiza® (lubiprostone)?

Get emergency medical help if you have any signs of an allergic reaction to Amitiza®: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have;

  • Severe or ongoing nausea or diarrhea
  • A light-headed feeling, like you might pass out

Common side effects may include:

  • Mild nausea, stomach pain
  • Mild diarrhea, gas, bloating
  • Headache

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.


What drugs may interact with Amitiza® (lubiprostone)?

Amitiza® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Amitiza® (lubiprostone)?

Amitiza® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Amitiza® (lubiprostone)?

Amitiza® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Amitiza® (lubiprostone).

What is the dose of Amitiza® (lubiprostone) for an adult?

Chronic Idiopathic Constipation and Opioid-Induced Constipation

The recommended dose is 24 mcg twice daily.

Irritable Bowel Syndrome with Constipation

The recommended dose is 8 mcg twice daily.

What is the dose of Amitiza® (lubiprostone) for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Amitiza® (lubiprostone) available?

Amitiza® is available in the following dosage forms and strengths:

  • Capsule, gelatin coated: lubiprostone 8ug

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Amitiza®, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.


Review Date: August 21, 2017 | Last Modified: September 2, 2017

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