Amiloride hydrocloride

By Medically reviewed by hellodoktor

Generic Name: Amiloride hydrocloride Brand Name(s): Generics only. No brands available.


What is amiloride HCL used for?

Amiloride HCL is a potassium-sparing diuretic. It works by making the kidneys eliminate sodium (salt) and water from the body while retaining potassium.

Amiloride HCL is commonly used for preventing development of low blood potassium or helping to restore normal blood potassium in patients with high blood pressure or heart failure.

It is usually used with other medicines. It may also be used for other conditions as determined by your doctor.

How should I take amiloride HCL?

Take amiloride HCL by mouth with food.

Amiloride HCL may increase the amount of urine or cause you to urinate more often when you first start taking it. To keep this from disturbing your sleep, try to take your dose before 6 pm.

Ask your health care provider any questions you may have about how to use amiloride HCL.

How do I store amiloride HCL?

Amiloride HCL is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store amiloride HCL in the bathroom or the freezer. There may be different brands of amiloride HCL that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush amiloride HCL down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using amiloride HCL?

Before using this drug, tell your doctor if:

  • You are allergic to any ingredient in amiloride HCL.
  • You are taking potassium supplements or potassium-sparing diuretics (e.g., aldosterone, triamterene).
  • You are unable to urinate.
  • You have high blood potassium levels or kidney problems due to diabetes or other severe kidney diseases.

Also, these are important safety information that you may notice:

  • Amiloride HCL may cause drowsiness. These effects may be worse if you take it with alcohol or certain medicines. Use amiloride HCL with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Check with your doctor before you use a salt substitute or a product that has potassium in it.
  • Lab tests, including electrolyte levels and blood pressure monitoring, may be performed while you use amiloride HCL. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use amiloride HCL with caution in the elderly; they may be more sensitive to its effects.
  • Amiloride HCL should not be used in children; safety and effectiveness in children have not been confirmed.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using amiloride HCL during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking amiloride HCL. Amiloride HCL is pregnancy risk category B, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from amiloride HCL?

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most common side effects persist or become bothersome:

Seek medical attention right away if any of these severe side effects occur:

  • Rash
  • Hives
  • Itching
  • Difficulty breathing
  • Tightness in the chest
  • Swelling of the mouth, face, lips, or tongue
  • Dry mouth
  • Excessive thirst
  • Slowed heart rate
  • Unusual muscle weakness
  • Unusual tiredness
  • Vomiting

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.


What drugs may interact with amiloride HCL?

Amiloride HCL may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Products may interact with this drug, including:

  • Angiotensin-converting enzyme (ACE) inhibitors (e.g., enalapril), angiotensin II receptor antagonists (e.g., valsartan), cyclosporine, other potassium-sparing diuretics (e.g., aldosterone, triamterene) or potassium supplements, because high blood potassium levels may occur and cause listlessness, confusion, abnormal skin sensations of the arms and legs, heaviness of the limbs, slow or irregular heartbeat, or stopping of the heart.
  • Nonsteroidal anti-inflammatory drugs (NSAIDs) (e.g., indomethacin), because they may decrease amiloride’s effectiveness and increase the risk of kidney problems and high blood potassium levels.
  • Lithium or quinidine, because the risk of their side effects and toxicity may be increased by amiloride HCL.

Does food or alcohol interact with amiloride HCL?

Amiloride HCL may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with amiloride HCL?

Amiloride HCL may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Especially, if you have:

  • Heart problems
  • Diabetes
  • Kidney damage caused by diabetes
  • Liver or kidney problems
  • Low blood sodium levels
  • A high acidity of body fluids
  • Dehydrated


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using amiloride HCL.

What is the dose of amiloride HCL for an adult?


The initial dose is 10mg, which may be given as a single or divided dose. This may be increased if necessary to a maximum of 20mg daily.

When diuresis has been achieved, the dosage may be reduced by 5mg increments to the least amount required.

In conjunction with other diuretic therapy: 

When amiloride HCL is used with a diuretic which is given on an intermittent basis, it should be given at the same time as the diuretic.

Congestive heart failure:

The initial dose is 5-10mg daily, together with the usual dosage of the diuretic concurrently employed. Where diuresis is not achieved dosage of both agents may be increased if necessary, however, the maximum dose for amiloride HCL is 20mg a day.

Once diuresis is achieved, reduction in dosage of both agents may be attempted for maintenance therapy. The dosage of both drugs is determined by diuresis and the level of plasma potassium.


The recommended dose is 5-10mg daily, together with the usual antihypertensive dosage of the thiazide concurrently employed. It is not usually necessary to exceed 10mg of amiloride HCL daily; in any event, not more than 20mg a day should be given.

Hepatic cirrhosis with ascites: 

When used in conjunction with another diuretic, treatment should be commenced with a small amiloride HCL dose of 5mg, plus a low dosage of the other diuretic agent. If necessary, dosage of both agents may gradually be increased until there is effective diuresis.

The maximum dose for amiloride HCL is 20mg daily. Maintenance doses may be lower than those required to initiate diuresis; reduction in the daily dosage should therefore be attempted when the patient’s weight is stabilized.


Dosage in the elderly should be carefully adjusted according to renal function, blood electrolytes and diuretic response. The elderly are more susceptible to electrolyte imbalance and more likely to experience hyperkalaemia since renal reserve may be reduced.

What is the dose of amiloride HCL for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is amiloride HCL available?

Amiloride HCL is available in the following dosage forms and strengths:

  • Amiloride HCL Hydrochloride 5mg

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of amiloride HCL, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Review Date: March 19, 2017 | Last Modified: September 13, 2019

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