By Medically reviewed by hellodoktor

Generic Name: Amfepramone Brand Name(s): Generics only. No brands available.


What is amfepramone used for?

Amfepramone is indicated for treating obesity.

How should I take amfepramone?

Amfepramone is should be taken on an empty stomach. Take 1 hour before meals.

How do I store amfepramone?

Amfepramone is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store amfepramone in the bathroom or the freezer. There may be different brands of amfepramone that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush amfepramone down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using amfepramone?

Before using this drug, tell your doctor if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with any of active or inactive ingredients of amfepramone or other medications.
  • You have any other illnesses, disorders, or medical conditions.

Caution is always emphasized when taking amfepramone, especially if performing activities such as driving or machine operation.

Amfepramone is a stimulant medicament, masking tiredness, which causes fatigue leading to problems in vision, speech and motion. Amfepramone is habit forming.

Patients with a recorded history of heart diseases or high blood pressure are not advised to take amfepramone. This also includes affected roles diagnosed with the condition arteriosclerosis or the stiffening of the arteries. Patients suffering from glaucoma are not to take this medicament.

Patients taking monoamine oxidase inhibitor medicaments (MAOIs) within the last two weeks may not be able to take amfepramone, as mixing MAOIs with amfepramone may have a lethal effect on the affected role. Patients with a known history of medicament and alcohol abuse are prohibited from taking the medicament as it is habit forming and they may have a hard time stopping the use of the medicament.

Amfepramone may not be taken with other anorectic medicaments that may be prescribed, over the counter or herbal medicaments.

This drug may increase risk of developing primary pulmonary HTN (PPH). Prolonged use may induce dependence with withdrawal symptoms on cessation of therapy; do not use for more than 3 months. May increase convulsions in some epileptic patients.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using amfepramone during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking amfepramone. Amfepramone is pregnancy risk category B, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown


Side effects

What side effects can occur from amfepramone?

Amfepramone affects the central nervous system, having side effects such as wamble, cephalalgias, bouts of insomnia, psychosis, and the more serious side effects such as pulmonary hypertension, and ultimately a stroke.

Less common side effects include xerostalmia, or a metallic taste in foods, blurred vision or photosensitivity, and allergies and rashes. Greater and more serious side effects include decrease in the affected role’s libido (sexual activity), which may lead to eventual erectile dysfunction.

There have been reported neurological and psychological side effects brought about by amfepramone such as depression, mood condition, drilling cephalalgias, restlessness, tremors, dizziness and seizures.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.


What drugs may interact with amfepramone?

Amfepramone may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with amfepramone?

Amfepramone may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with amfepramone?

Amfepramone may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Health conditions that may interact with this drug are:

  • HTN and severe CV disease
  • Toxic psychosis
  • Peptic ulceration
  • Prostatic hyperplasia



The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using amfepramone.

What is the dose of amfepramone for an adult?

Oral – Obesity

Adult: 25 mg tid or 75 mg once daily in mid-morning as a modified-release preparation.

What is the dose of amfepramone for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is amfepramone available?

Amfepramone is available in the following dosage forms and strengths:

  • Tablet

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of amfepramone, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Review Date: October 3, 2017 | Last Modified: September 11, 2019

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