Amantadine

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Generic Name: Amantadine Brand Name(s): Amantadine.

Uses

What is amantadine used for?

Amantadine is commonly used for to treat or prevent the flu. It is used to treat side effects caused by some other drugs.

It is used to treat Parkinson’s disease. It may be given to you for other reasons. Talk with the doctor.

How should I take amantadine?

Use this medicine as ordered by your doctor. Read all information given to you. Follow all instructions closely. Take with or without food.

Keep taking this medicine (amantadine capsules and tablets) as you have been told by your doctor or other health care provider, even if you feel well.

How do I store amantadine?

Amantadine is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store amantadine in the bathroom or the freezer. There may be different brands of amantadine that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush amantadine down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using amantadine?

Before using this drug, tell your doctor if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with any of active or inactive ingredients of amantadine or other medications.
  • You have any other illnesses, disorders, or medical conditions.
  • You are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • You have glaucoma.

Tell all of your health care providers that you take this medicine. This includes your doctors, nurses, pharmacists, and dentists.

Avoid driving and doing other tasks or actions that call for you to be alert or have clear eyesight until you see how this medicine (amantadine capsules and tablets) affects you.

To lower the chance of feeling dizzy or passing out, rise slowly over a few minutes when sitting or lying down. Be careful climbing stairs.

Heat stroke has happened in people taking this medicine. Be careful in hot weather and during physical activity.

Talk with your doctor before getting a flu vaccine after taking this medicine (amantadine capsules and tablets). Talk with your doctor before you take this medicine if you have just gotten a flu vaccine.

Talk with your doctor before you drink alcohol or use other drugs and natural products that slow your actions.

If you have kidney problems, talk with your doctor. Your dose may need to be changed based on how well your kidneys work. Deaths have happened in people with kidney problems whose dose was too high for their kidney function.

Deadly overdoses have happened with this medicine (amantadine capsules and tablets) in adults and children. Keep away from children. Do not take more than you were told. If this drug is taken by accident, call your poison control center or get medical care right away.

If you are 65 or older, use this medicine with care. You could have more side effects.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using amantadine during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking amantadine. Amantadine is pregnancy risk category C, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from amantadine?

Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat
  • Change in how you act
  • Feeling confused
  • Very bad dizziness or passing out
  • Hallucinations (seeing or hearing things that are not there)
  • Seizures
  • Shortness of breath, a big weight gain, or swelling in the arms or legs
  • Trouble passing urine
  • Blurred eyesight
  • Strong urges that are hard to control (such as eating, gambling, sex, or spending money)
  • Change in balance

Patients who take this medicine (amantadine capsules and tablets) may be at a greater risk of having thoughts or actions of suicide. The risk may be greater in people who have had these thoughts or actions in the past. Call the doctor right away if signs like low mood (depression), nervousness, restlessness, grouchiness, panic attacks, or changes in mood or actions are new or worse. Call the doctor right away if any thoughts or actions of suicide occur.

A very bad and sometimes deadly health problem called neuroleptic malignant syndrome (NMS) may happen. Call your doctor right away if you have any fever, muscle cramps or stiffness, dizziness, very bad headache, confusion, change in thinking, fast heartbeat, heartbeat that does not feel normal, or are sweating a lot.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with amantadine?

Amantadine may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with amantadine?

Amantadine may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with amantadine?

Amantadine may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using amantadine.

What is the dose of amantadine for an adult?

Usual Adult Dose for Influenza Prophylaxis

Normally recommended dose: 200 mg orally per day in 1 to 2 divided doses

Usual Adult Dose for Influenza A

Normally recommended dose: 200 mg orally per day in 1 to 2 divided doses

Usual Adult Dose for Parkinson’s Disease

Monotherapy:

100 mg orally twice a day; onset usually within 48 hours

In patients with serious associated medical illnesses or receiving high doses of other antiparkinson drugs:

Initial dose: 100 mg once a day

After 1 to several weeks at initial dose: The dose may be increased to 100 mg orally twice a day, if needed.

Usual Adult Dose for Extrapyramidal Reaction

100 mg orally twice a day

Usual Geriatric Dose for Influenza Prophylaxis

Normally recommended dose:

65 years or older: 100 mg orally per day

Usual Geriatric Dose for Influenza A

Normally recommended dose:

65 years or older: 100 mg orally per day

What is the dose of amantadine for a child?

Usual Pediatric Dose for Influenza Prophylaxis

Normally recommended doses:

  • 1 to 9 years: 4.4 to 8.8 mg/kg orally per day; not to exceed 150 mg/day
  • 10 to 12 years: 100 mg orally twice a day

Advisory Committee on Immunization Practices (ACIP) and American Academy of Pediatrics (AAP) recommendations (to reduce risk for toxicity):

  • 1 to 9 years: 5 mg/kg orally per day in 2 divided doses; not to exceed 150 mg/day
  • 10 years or older, less than 40 kg: 5 mg/kg orally per day
  • 10 years or older, 40 kg or more: 100 mg orally twice a day
  • Alternative prophylactic dose for children weighing more than 20 kg: 100 mg per day

Usual Pediatric Dose for Influenza A

Normally recommended doses:

  • 1 to 9 years: 4.4 to 8.8 mg/kg orally per day; not to exceed 150 mg/day
  • 10 to 12 years: 100 mg orally twice a day

Advisory Committee on Immunization Practices (ACIP) and American Academy of Pediatrics (AAP) recommendations (to reduce risk for toxicity):

  • 1 to 9 years: 5 mg/kg orally per day in 2 divided doses; not to exceed 150 mg/day
  • 10 years or older, less than 40 kg: 5 mg/kg orally per day
  • 10 years or older, 40 kg or more: 100 mg orally twice a day

Alternative prophylactic dose for children weighing more than 20 kg: 100 mg per day

How is amantadine available?

Amantadine is available in the following dosage forms and strengths:

  • Capsule
  • Tablet

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of amantadine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Review Date: October 3, 2017 | Last Modified: October 3, 2017

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