Generic Name: Alpha-1 Proteinase Inhibitor Brand Name(s): Generics only. No brands available. Avability: Rx Pregnancy Category: N

Uses

What is Alpha 1-Proteinase Inhibitor used for?

Alpha 1-Proteinase Inhibitor is used to treat lung problems (emphysema) caused by a certain inherited disease (alpha-1-proteinase inhibitor deficiency). In people with this condition, lung damage is caused by elastase, a natural substance that the body needs to kill bacteria in the lungs. Normally, a protein (alpha-1-proteinase inhibitor) stops elastase from working when it is no longer needed. However, in people who do not make enough of this protein, elastase does not stop working and damages the lungs. This medication replaces the missing alpha-1-proteinase inhibitor and helps to prevent further lung damage.

How should I take Alpha 1-Proteinase Inhibitor?

This medication is given by injection into a vein, usually once a week or as directed by your doctor.

If you are giving this medication at home, learn all preparation and usage instructions in the product package and from your health care professional. If any of the information is unclear, consult your doctor or pharmacist. If your brand of medication is stored in the refrigerator, allow the medication and mixing solution to warm to room temperature before mixing. Do not shake the mixed drug. Doing so may decrease the effectiveness of this medication.

Before using, check the product visually for particles or discoloration. Occasionally, a few small particles may remain in the vial. These particles will be removed by the filter provided with the medication. If the product is discolored, do not use the liquid.

Learn how to store and discard needles and medical supplies safely. Consult your pharmacist for details.

Dosage is based on your weight, medical condition and response to treatment.

Use this medication regularly to get the most benefit from it. To help you remember, mark a reminder on a calendar and use it on the same day each week.

Tell your doctor if your condition worsens after several weeks.

How do I store Alpha 1-Proteinase Inhibitor?

Alpha 1-Proteinase Inhibitor is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Alpha 1-Proteinase Inhibitor in the bathroom or the freezer. There may be different brands of Alpha 1-Proteinase Inhibitor that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Alpha 1-Proteinase Inhibitor down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

 

Precautions & warnings

What should I know before using Alpha 1-Proteinase Inhibitor?

Before using alpha-1-proteinase inhibitor, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: selective IgA deficiency with antibodies to IgA, liver disease, heart problems (such as heart failure).

Since this medication is made from human blood, there is a very small chance that you may get infections from it (such as viral infections like hepatitis). It is recommended that you get the appropriate vaccinations (such as for hepatitis A and B) and that people giving this medication handle the medication with special caution to prevent virus infections. Consult your doctor for more details.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is unknown whether this drug passes into breast milk. Consult your doctor before breast-feeding.

Is it safe during pregnancy or breast-feeding?

There are no adequate studies in women for determining risk when using this Alpha 1-Proteinase Inhibitor during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Alpha 1-Proteinase Inhibitor. Alpha 1-Proteinase Inhibitor is pregnancy risk category N according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown

Side effects

What side effects can occur from Alpha 1-Proteinase Inhibitor?

Pain at the injection site, fever, dizziness, headache, drowsiness, numb/tingling skin, and muscle aches may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

This medication is made from human blood. There is a very small chance that you may get infections from this medication (including viral infections such as hepatitis, parvovirus B19), even though careful screening of blood donors, special manufacturing processes, and many tests are all used to reduce this risk. Discuss the benefits and risks of treatment with your doctor. Tell your doctor right away if you develop any signs of hepatitis or other infection, including persistent fever, persistent sore throat, stuffy nose, unusual tiredness, unusual drowsiness, joint pain, persistent nausea/vomiting, stomach/abdominal pain, yellowing eyes/skin, dark urine.

A very serious allergic reaction to this drug is rare. However, stop receiving the drug and seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: hives, rash, itching/swelling (especially of the face/tongue/throat), chest tightness, severe dizziness, trouble breathing.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Alpha 1-Proteinase Inhibitor?

Alpha 1-Proteinase Inhibitor may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Alpha 1-Proteinase Inhibitor?

Alpha 1-Proteinase Inhibitor may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

This drug may make you dizzy or drowsy. Alcohol or marijuana can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana.

What health conditions may interact with Alpha 1-Proteinase Inhibitor?

Alpha 1-Proteinase Inhibitor may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this Alpha 1-Proteinase Inhibitor.

What is the dose of Alpha 1-Proteinase Inhibitor for an adult?

Usual Adult Dose for Alpha-1 Proteinase Inhibitor Deficiency

60 mg/kg intravenously once a week

Do not mix with other agents or diluting solutions. Monitor the infusion rate closely during administration and observe the patient for infusion related reactions.

What is the dose of Alpha 1-Proteinase Inhibitor for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Alpha 1-Proteinase Inhibitor available?

Alpha 1-Proteinase Inhibitor is available in the following dosage forms and strengths:

  • Intravenous powder for injection,
  • Intravenous solution.

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Alpha 1-Proteinase Inhibitor, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

 

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: November 16, 2018 | Last Modified: November 16, 2018

Want to live your best life?
Get the Hello Doktor Daily newsletter for health tips, wellness updates and more.