Generic Name: Allopurinol-Lesinurad Brand Name(s): Generics only. No brands available. Avability: Rx Pregnancy Category: N

Uses

What is Allopurinol-Lesinurad used for?

Allopurinol-Lesinurad is a combination medication. It works by decreasing the amount of uric acid your body makes, and by helping the kidneys get rid of uric acid. Increased uric acid levels can cause gout attacks. This combination medication is used to lower uric acid when allopurinol alone has not worked well enough. This effect helps prevent gout flares/attacks.

How should I take Allopurinol-Lesinurad?

Take this medication by mouth with food as directed by your doctor, usually once daily in the morning with a full glass of water (240 milliliters). Drink plenty of fluids (at least 8 full glasses a day) while taking this medication to help it work better, unless otherwise directed by your doctor.

If you are switching from taking lesinurad or allopurinol to this combination product, be sure to stop taking the other lesinurad or allopurinol product to avoid taking too much medication(s) and increasing the risk of side effects.

You may have more gout attacks for several months after you start taking this medicine while your body gets rid of extra uric acid. Do not stop taking this medication if you have a gout flare/attack. This medication is not for treating gout attacks. Your doctor may prescribe other medication (including colchicine, NSAIDs such as ibuprofen, naproxen, or indomethacin) to prevent or treat a gout attack while you are taking this medication. Continue to take lesinurad/allopurinol and your prescribed medicines for gout attacks as directed by your doctor. Tell your doctor if your condition does not get better or if it gets worse.

How do I store Allopurinol-Lesinurad?

Allopurinol-Lesinurad is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Allopurinol-Lesinurad in the bathroom or the freezer. There may be different brands of Allopurinol-Lesinurad that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Allopurinol-Lesinurad down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Allopurinol-Lesinurad?

Before taking this medication, tell your doctor or pharmacist if you are allergic to lesinurad or allopurinol; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, liver problems, cancer treatment, a certain inherited disease (Lesch-Nyhan syndrome).

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is unknown if lesinurad passes into breast milk. Allopurinol passes into breast milk. Consult your doctor before breast-feeding.

Is it safe during pregnancy or breast-feeding?

There are no adequate studies in women for determining risk when using this Allopurinol-Lesinurad during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Allopurinol-Lesinurad. Allopurinol-Lesinurad is pregnancy risk category N according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown

Side effects

What side effects can occur from Allopurinol-Lesinurad?

Stomach upset, nausea, diarrhea, or drowsiness may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

Tell your doctor right away if you have any serious side effects, including: numbness/tingling of arms/legs, easy bleeding/bruising, unusual tiredness, unusual weight loss, signs of infection (such as sore throat that doesn’t go away, fever, chills), signs of liver problems (such as nausea/vomiting that doesn’t stop, loss of appetite, stomach/abdominal pain, yellowing eyes/skin, dark urine).

Rarely, heart-related problems or stroke have occurred in people taking lesinurad in combination with allopurinol. However, it is not known if these medications caused these problems. Get medical help right away if you have any of these very seriousweakness on one side of the body, sudden vision changes, trouble speaking, confusion, chest/jaw/left arm pain, shortness of breath, unusual sweating.

This medication can commonly cause a rash that is usually not serious. However, you may not be able to tell it apart from a rare rash that could be a sign of a severe reaction. Get medical help right away if you develop any rash.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Allopurinol-Lesinurad?

Some products that may interact with this drug are: didanosine, valproic acid, “blood thinners” (such as warfarin, dicoumarol).

This medication may decrease the effectiveness of hormonal birth control such as pills, patch, or ring. This could cause pregnancy. Discuss with your doctor or pharmacist if you should use reliable backup birth control methods while using this medication. Also tell your doctor if you have any new spotting or breakthrough bleeding, because these may be signs that your birth control is not working well.

Aspirin can decrease the effects of this medication. However, if your doctor has directed you to take low-dose aspirin for heart attack or stroke prevention (usually at dosages of 81-325 milligrams a day), you should continue taking it unless your doctor instructs you otherwise. Ask your doctor or pharmacist for more details.

Allopurinol-Lesinurad may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Allopurinol-Lesinurad?

Allopurinol-Lesinurad may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

This drug may make you drowsy. Alcohol or marijuana can make you more drowsy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana.

What health conditions may interact with Allopurinol-Lesinurad?

Allopurinol-Lesinurad may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

 

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this Allopurinol-Lesinurad.

What is the dose of Allopurinol-Lesinurad for an adult?

Usual Adult Dose for Gout

Initial dose:

-Patients taking allopurinol doses greater than 300 mg/day: Allopurinol 300 mg-lesinurad 200 mg orally once a day

-Patients taking allopurinol doses of 300 mg/day: Allopurinol 300 mg-lesinurad 200 mg orally once a day

-Patients taking allopurinol doses of 200 mg/day: Allopurinol 200 mg-lesinurad 200 mg orally once a day

Renal Dose Adjustments

Prior to initiation:

-Mild to moderate renal dysfunction (CrCl greater than 45 mL/min): No adjustment recommended.

-Severe renal impairment (CrCl less than 45 mL/min): Contraindicated

During treatment:

-Mild renal dysfunction (CrCl greater than 60 mL/min): No adjustment recommended.

-Moderate renal dysfunction (CrCl 45 to 60 mL/min): Frequent monitoring recommended.

-Severe renal dysfunction (CrCl less than 45 mL/min): Discontinue use in patients with persistent severe renal dysfunction.

-Serum creatinine levels 1.5 to 2 times pretreatment levels: Frequent monitoring recommended.

-Serum creatinine levels greater than 2 times pretreatment level: Interrupt therapy; do not restart without another explanation for serum creatinine abnormalities.

Liver Dose Adjustments

Mild to moderate liver dysfunction (Child-Pugh Classes A and B): No adjustment recommended.

Severe liver dysfunction (Child-Pugh Class C): Not recommended.

Dose Adjustments

Patients taking azathioprine or mercaptopurine:

-Initial dose: Reduce the dose of azathioprine or mercaptopurine to approximately one-third to one-fourth of the usual dose.

-Subsequent doses: Adjustments should be made based upon therapeutic response and signs/symptoms of toxicity.

-Patients should be monitored for therapeutic response and signs/symptoms of toxicity.

What is the dose of Allopurinol-Lesinurad for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Allopurinol-Lesinurad available?

Allopurinol-Lesinurad is available in the following dosage forms and strengths:

  • Oral tablet.

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Allopurinol-Lesinurad, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

 

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: November 15, 2018 | Last Modified: November 15, 2018

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