Aliskiren-Amlodipine

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Generic Name: Aliskiren-Amlodipine Brand Name(s): Generics only. No brands available. Avability: Rx Pregnancy Category: N

Uses

What is Aliskiren-Amlodipine used for?

Aliskiren-Amlodipine is a combination medication used to treat high blood pressure (hypertension). Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. This product contains 2 medications: aliskiren and amlodipine. They both work by relaxing blood vessels so blood can flow more easily. Aliskiren is a direct renin inhibitor and amlodipine is a calcium channel blocker.

How should I take Aliskiren-Amlodipine?

Take this medication by mouth as directed by your doctor, usually once daily. You may take this medication with or without food, but it is important to choose one way and take this medication the same way with every dose. The dosage is based on your medical condition and response to treatment.

Tell your doctor if your condition does not improve or if it worsens (your blood pressure readings remain high or increase).

How do I store Aliskiren-Amlodipine?

Aliskiren-Amlodipine is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Aliskiren-Amlodipine in the bathroom or the freezer. There may be different brands of Aliskiren-Amlodipine that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Aliskiren-Amlodipine down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Aliskiren-Amlodipine?

Before taking this product, tell your doctor or pharmacist if you are allergic to aliskiren or amlodipine; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: diabetes, kidney disease, liver disease, severe loss of body water and minerals (dehydration), certain heart valve conditions (aortic/mitral stenosis).

Too much sweating, diarrhea, or vomiting may cause you to feel lightheaded. Report prolonged diarrhea or vomiting to your doctor.

This product may increase your potassium levels. Before using potassium supplements or salt substitutes that contain potassium, consult your doctor or pharmacist.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Older adults may be more sensitive to the effects of this product, especially dizziness.

This medication is not recommended for use during pregnancy. It may harm an unborn baby. Consult your doctor for more details. (See also Warning section.)

It is unknown if aliskiren passes into breast milk. Amlodipine passes into breast milk. Consult your doctor before breast-feeding.

Is it safe during pregnancy or breast-feeding?

There are no adequate studies in women for determining risk when using this Aliskiren-Amlodipine during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Aliskiren-Amlodipine. Aliskiren-Amlodipine is pregnancy risk category N according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown

Side effects

What side effects can occur from Aliskiren-Amlodipine?

Dizziness or lightheadedness may occur as your body adjusts to the medication. If either of these effects persists or worsens, tell your doctor or pharmacist promptly.

To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.

Tell your doctor right away if you have any serious side effects, including: swelling hands/ankles/feet, fainting, fast heartbeat, signs of kidney problems (such as change in the amount of urine), symptoms of a high potassium blood level (such as muscle weakness, slow/irregular heartbeat).

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Aliskiren-Amlodipine?

Some products that may interact with this medication include: drugs that may increase the level of potassium in the blood (including ACE inhibitors such as benazepril/lisinopril, ARBs such as candesartan/losartan, birth control pills containing drospirenone).

Other medications can affect the removal of aliskiren from your body, which may affect how aliskiren works. Examples include itraconazole, cyclosporine, quinidine, among others.

Aliskiren-Amlodipine may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Aliskiren-Amlodipine?

Aliskiren-Amlodipine may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

Do not take with fruit juices (such as apple, grapefruit, or orange) since they may decrease the absorption of this drug.

High-fat foods may decrease how well this drug is absorbed by the body, so it is best to avoid taking this medication with a high-fat meal.

This drug may make you dizzy. Alcohol or marijuana can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana.

What health conditions may interact with Aliskiren-Amlodipine?

Aliskiren-Amlodipine may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Some people who already have severe heart disease may rarely develop worsening chest pain or a heart attack after starting this medication or increasing the dose. Get medical help right away if you experience: worsening chest pain, symptoms of a heart attack (such as chest/jaw/left arm pain, shortness of breath, unusual sweating).

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this Aliskiren-Amlodipine.

What is the dose of Aliskiren-Amlodipine for an adult?

Usual Adult Dose for Hypertension

Initial or add-on therapy: 150 mg/5 mg orally once a day. Titrate as needed up to a maximum of 300 mg/10 mg.

The blood pressure lowering effect is largely attained within 1 to 2 weeks.

Maximum dose: 300 mg/10 mg

Usual Geriatric Dose for Hypertension

Exposure to aliskiren and amlodipine is increased in elderly patients. Lower initial doses of aliskiren-amlodipine should be considered.

Renal Dose Adjustments

CrCl less than 30 mL/min: Not recommended

Liver Dose Adjustments

Exposure to amlodipine is increased in patients with hepatic insufficiency. Lower doses should be considered in these patients.

What is the dose of Aliskiren-Amlodipine for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Aliskiren-Amlodipine available?

Aliskiren-Amlodipine is available in the following dosage forms and strengths:

  • Oral tablet.

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Aliskiren-Amlodipine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: November 15, 2018 | Last Modified: November 15, 2018

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