Alirocumab

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Generic Name: Alirocumab Brand Name(s): Generics only. No brands available. Avability: Rx Pregnancy Category: N

Uses

What is Alirocumab used for?

Alirocumab is used along with a proper diet and maximally tolerated “statin” drugs to help lower “bad” cholesterol (LDL) in the blood. It is used by people who have an inherited condition that causes high levels of LDL or who have blockage in the heart blood vessels, who need more lowering of LDL levels. Alirocumab belongs to a class of drugs known as monoclonal antibodies. It works by improving how well your body gets rid of LDL cholesterol.

How should I take Alirocumab?

Before use, take alirocumab out of the refrigerator and let it warm up to room temperature for 30 to 40 minutes. Do not heat this medication any other way, such as by heating in the microwave or placing in hot water. If needed, this medication may be kept in the original package at room temperature for up to 30 days.

Do not shake this medication. Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid.

Inject this medication under the skin of the thigh, abdomen, or upper arm as directed by your doctor, usually once every 2 weeks, or once every 4 weeks (monthly). The dosage is based on your medical condition and response to treatment.

Before injecting each dose, clean the injection site with rubbing alcohol. Change the injection site each time to lessen injury under the skin. Do not inject into any areas of skin that are injured, tender, hard, red, or hot.

How do I store Alirocumab?

Alirocumab is best stored at at 2°C to 8°C in the outer carton to protect from light. If needed, solution may be kept at room temperature up to 25°C for a maximum of 30 days in original carton to protect from light. Do not store >25°C. After removal from the refrigerator, solution must be used within 30 days or discarded. Do not freeze. Do not expose to extreme heat. Do not shake.

There may be different brands of Alirocumab that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Alirocumab down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Alirocumab?

Before using alirocumab, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using this medication, tell your doctor or pharmacist your medical history.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is unknown if this medication passes into breast milk. Consult your doctor before breast-feeding.

Is it safe during pregnancy or breast-feeding?

There are no adequate studies in women for determining risk when using this Alirocumab during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Alirocumab. Alirocumab is pregnancy risk category N according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown

Side effects

What side effects can occur from Alirocumab?

Redness, itching, swelling, or pain at the injection site may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Alirocumab?

Alirocumab may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Alirocumab?

Alirocumab may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Alirocumab?

Alirocumab may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this Alirocumab.

What is the dose of Alirocumab for an adult?

Usual Adult Dose for Homozygous Familial Hypercholesterolemia

Initial dose: 75 mg subcutaneously every 2 weeks

Maximum dose: 150 mg subcutaneously every 2 weeks, if the LDL-C response to initial dose is inadequate

Usual Adult Dose for Cardiovascular Risk Reduction

Initial dose: 75 mg subcutaneously every 2 weeks

Maximum dose: 150 mg subcutaneously every 2 weeks, if the LDL-C response to initial dose is inadequate

Renal Dose Adjustments

Mild to moderate renal dysfunction: No adjustment recommended.

Liver Dose Adjustments

Mild to moderate hepatic dysfunction: No adjustment recommended.

What is the dose of Alirocumab for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Alirocumab available?

Alirocumab is available in the following dosage forms and strengths:

  • Subcutaneous solution.

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Alirocumab, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Review Date: November 15, 2018 | Last Modified: November 15, 2018

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