Generic Name: Alfentanil Brand Name(s): Generics only. No brands available.


What is alfentanil hydrochloride used for?

Alfentanil hydrochloride is indicated:

  • As an analgesic adjunct given in incremental doses in the maintenance of anesthesia with barbiturate/nitrous oxide/oxygen.
  • As an analgesic administered by continuous infusion with nitrous oxide/oxygen in the maintenance of general anesthesia.
  • As a primary anesthetic agent for the induction of anesthesia in patients undergoing general surgery in which endotracheal intubation and mechanical ventilation are required.
  • As the analgesic component for monitored anesthesia care (MAC).

How should I take alfentanil hydrochloride?

Alfentanil hydrochloride is taken through intravenous infusion.

How do I store alfentanil hydrochloride?

Alfentanil hydrochloride is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store alfentanil hydrochloride in the bathroom or the freezer. There may be different brands of alfentanil hydrochloride that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush alfentanil hydrochloride down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using alfentanil hydrochloride?

Before using this drug, tell your doctor if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with any of active or inactive ingredients of alfentanil hydrochloride or other medications.
  • You have any other illnesses, disorders, or medical conditions.

Obstructive airway disease or respiratory depression if not ventilating.

Concurrent administration with monoamine oxidase inhibitors or within 2 weeks of their discontinuation.

Administration in labor or before clamping of the cord during Caesarian section due to the possibility of respiratory depression in the new-born infant.

Delayed respiration depression, respiratory arrest, bradycardia, asystole, arrhythmias and hypotension have also been reported. Therefore, vital signs must be monitored continuously.

Is it safe during pregnancy or breastfeeding?

There isn’t enough information about the safety of using alfentanil hydrochloride during pregnancy and breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking alfentanil hydrochloride.

Side effects

What side effects can occur from alfentanil hydrochloride?

Side effects may occur when using this drug, such as:

  • Nausea
  • Headache
  • Hypotension
  • Pain on injection site
  • Pruritus/itching
  • Respiratory depression/ hypoxemia
  • Sleepiness/dizziness/drowsiness
  • Vomiting
  • Bradycardia
  • Coughing
  • Excitation
  • Hypertension
  • Laryngospasm/bronchospasm
  • Muscle rigidity
  • Shivering/feeling of cold
  • Tachycardia
  • Urinary retention
  • Visual disturbances

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.


What drugs may interact with alfentanil hydrochloride?

Alfentanil hydrochloride may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with alfentanil hydrochloride?

Alfentanil hydrochloride may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with alfentanil hydrochloride?

Alfentanil hydrochloride may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using alfentanil hydrochloride.

What is the dose of alfentanil hydrochloride for an adult?

Alfentanil 5 mg/ml solution for injection should be diluted with sodium chloride intravenous infusion BP, glucose intravenous infusion BP, or compound sodium lactate intravenous infusion BP (Hartmann’s solution). Such dilutions are compatible with plastic bags and giving sets. These dilutions should be used within 24 hours of preparation.

Once the patient has been intubated, mechanical ventilation can be initiated using the following dosage regimen:

  • The recommended initial infusion rate for mechanically ventilated adult patients is 2 mg per hour (equivalent to 0.4 ml per hour) of undiluted Alfentanil 5 mg/ml solution for injection. For a 70 kg patient, this corresponds to approximately 30 micrograms per kilogram per hour.
  • More rapid control may initially be gained by using a loading dose. For example, a dose of 5 mg may be given in divided doses over a period of 10 minutes, during which time careful monitoring of blood pressure and heart rate should be performed. If hypotension or bradycardia occurs, the rate of administration should be reduced accordingly and other appropriate measures instituted.
  • The dose to produce the desired effects should then be individually determined and reassessed regularly to ensure that the optimum dose is being used.
  • In clinical trials, patient requirements have generally been met with doses of 0.5 to 10 mg alfentanil per hour.
  • Additional bolus doses of 0.5 – 1.0 mg alfentanil may be given to provide analgesia during short painful procedures.

The elderly and those patients with liver impairment and hypothyroidism will require lower doses. Obese patients may require a dose based on their lean body mass.

The maximum recommended duration of treatment with alfentanil infusions is 4 days.

Present data suggest that clearance of alfentanil is unaltered in renal failure. However, there is an increased free fraction and hence dosage requirements may be less than in the patient with normal renal function.

What is the dose of alfentanil hydrochloride for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is alfentanil hydrochloride available?

Alfentanil hydrochloride is available in the following dosage forms and strengths:

  • Injection

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of alfentanil hydrochloride, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Review Date: September 20, 2017 | Last Modified: September 21, 2017

You might also like