Generic Name: Alectinib Brand Name(s): Generics only. No brands available. Avability: Rx Pregnancy Category: N

Uses

What is Alectinib used for?

Alectinib is used to treat a certain type of lung cancer that has spread to other parts of the body. It works by slowing or stopping the growth of cancer cells. Alectinib belongs to a class of drugs known as tyrosine kinase inhibitors.

How should I take Alectinib?

Take this medication by mouth with food as directed by your doctor, usually twice daily. Swallow the capsules whole. Do not open or dissolve the contents of the capsules. If you vomit after taking a dose, do not take an extra dose. Take your next dose at the regular time.

The dosage is based on your medical condition, side effects, lab test results, and response to treatment. Do not increase your dose or take this drug more often or for longer than prescribed. Your condition will not improve any faster, and your risk of serious side effects will increase.

Use this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day.

How do I store Alectinib?

Alectinib is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Alectinib in the bathroom or the freezer. There may be different brands of Alectinib that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Alectinib down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Alectinib?

Before taking alectinib, tell your doctor or pharmacist if you are allergic to it or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, slow heartbeat, kidney disease.

This medication may make you more sensitive to the sun. Limit your time in the sun. Avoid tanning booths and sunlamps during treatment and for at least 1 week after stopping this medication. Use sunscreen and wear protective clothing when outdoors. Tell your doctor right away if you get sunburned or have skin blisters/redness.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

This medication is not recommended for use during pregnancy. It may harm an unborn baby. It is important to prevent pregnancy while taking this medication. Consult your doctor for more details and to discuss the use of reliable forms of birth control (such as condoms, birth control pills) while taking this medication. Female patients should use reliable forms of birth control during treatment and for at least 1 week after stopping this drug. Male patients and their female partners should use reliable forms of birth control during treatment and for 3 months after stopping this drug. If you or your partner become pregnant or may be pregnant, tell your doctor right away.

It is unknown if this drug passes into breast milk. Because of the possible risk to the infant, breast-feeding is not recommended while using this medication and for 1 week after stopping this medication. Consult your doctor before breast-feeding.

Is it safe during pregnancy or breast-feeding?

There are no adequate studies in women for determining risk when using this Alectinib during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Alectinib. Alectinib is pregnancy risk category N according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown

Side effects

What side effects can occur from Alectinib?

Tiredness, constipation, nausea, vomiting, diarrhea, swelling ankles/feet/hands, back pain, headache, weight gain, or vision changes (such as blurred vision, decreased vision) may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

Tell your doctor right away if you have any serious side effects, including: signs of liver problems (such as nausea/vomiting that doesn’t stop, loss of appetite, stomach/abdominal pain, yellowing eyes/skin, dark urine), slow heartbeat, dizziness, lightheadedness, fainting, unexplained muscle pain/tenderness/weakness, signs of kidney problems (such as change in the amount of urine).

Get medical help right away if you have any very serious side effects, including: new/worsening lung disease (such as trouble breathing, shortness of breath, cough, fever), chest pain, sudden severe bleeding, black/bloody stools, vomit that contains blood or looks like coffee grounds.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Alectinib?

Alectinib may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Alectinib?

Alectinib may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

This drug may make you dizzy or cause vision changes. Alcohol or marijuana can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness or clear vision until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana.

What health conditions may interact with Alectinib?

Alectinib may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this Alectinib.

What is the dose of Alectinib for an adult?

Usual Adult Dose for Non-Small Cell Lung Cancer

600 mg orally twice a day

Duration of Therapy: Until disease progression or unacceptable toxicity

Renal Dose Adjustments

Mild to Moderate Renal Impairment (CrCl 30 to 89 mL/min): No adjustment recommended.

Liver Dose Adjustments

Mild Hepatic Impairment (Total bilirubin upper limit of normal [ULN] or less AND AST greater than ULN OR total bilirubin greater than 1.0 to 1.5 times ULN AND any AST): No adjustment recommended.

What is the dose of Alectinib for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Alectinib available?

Alectinib is available in the following dosage forms and strengths:

  • Oral capsule.

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Alectinib, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

 

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: November 15, 2018 | Last Modified: November 15, 2018

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