Generic Name: Aldactone Brand Name(s): Aldactone.

Uses

What is Aldactone® (spironolactone) used for?

Aldactone® is a potassium-sparing diuretic (water pill) that prevents your body from absorbing too much salt and keeps your potassium levels from getting too low.

Aldactone® is used to diagnose or treat a condition in which you have too much aldosterone in your body. Aldosterone is a hormone produced by your adrenal glands to help regulate the salt and water balance in your body.

Aldactone® also treats fluid retention (edema) in people with congestive heart failure, cirrhosis of the liver, or a kidney disorder called nephrotic syndrome. This medication is also used to treat or prevent hypokalemia (low potassium levels in the blood).

Aldactone® may also be used for purposes not listed in this medication guide.

How should I take Aldactone® (spironolactone)?

Take Aldactone® exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

While using Aldactone®, you may need frequent blood tests.

Aldactone® cause unusual results with certain medical tests. Tell any doctor who treats you that you are using this medicine.

If you need surgery, tell the surgeon ahead of time that you are using Aldactone®. You may need to stop using the medicine for a short time.

If you are being treated for high blood pressure, keep using this medication even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.

How do I store Aldactone® (spironolactone)?

Aldactone® is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Aldactone® in the bathroom or the freezer. There may be different brands of Aldactone® that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Aldactone® down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Aldactone® (spironolactone)?

Before using this drug, tell your doctor if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with any of active or inactive ingredients of Aldactone® or other medications.
  • You have any other illnesses, disorders, or medical conditions.

You should not use Aldactone® if you have:

  • Kidney disease, or if you are unable to urinate
  • Addison’s disease (an adrenal gland disorder)
  • High levels of potassium in your blood (hyperkalemia)
  • If you are also taking eplerenone

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using Aldactone® during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Aldactone®. Aldactone® is pregnancy risk category C, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from Aldactone® (spironolactone)?

Get emergency medical help if you have any signs of an allergic reaction to Aldactone®: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using Aldactone® and call your doctor at once if you have:

  • Signs of stomach bleeding – bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds
  • High potassium – slow heart rate, weak pulse, muscle weakness or limp feeling, tingly feeling
  • Low sodium – confusion, slurred speech, hallucinations, severe weakness, loss of coordination, feeling unsteady, seizure (convulsions), fainting, shallow breathing (breathing may stop)
  • Symptoms of any electrolyte imbalance – dry mouth, increased thirst, drowsiness, lack of energy, restless feeling, confusion, nausea, vomiting, increased urination, muscle cramps or weakness, fast heart rate, little or no urinating, or feeling like you might pass out

Common side effects may include:

  • Mild nausea or vomiting, diarrhea
  • Breast swelling or tenderness
  • Dizziness, headache, mild drowsiness
  • Leg cramps
  • Impotence, difficulty having an erection

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Aldactone® (spironolactone)?

Aldactone® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Aldactone® (spironolactone)?

Aldactone® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Aldactone® (spironolactone)?

Aldactone® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Aldactone® (spironolactone).

What is the dose of Aldactone® (spironolactone) for an adult?

Usual Adult Dose for Edema:

25 to 200 mg/day orally in 1 or 2 divided doses.

Usual Adult Dose for Hypertension:

25 to 200 mg/day orally in 1 or 2 divided doses.

Usual Adult Dose for Hypokalemia:

25 to 200 mg/day orally in 1 or 2 divided doses.

Usual Adult Dose for Primary Hyperaldosteronism Diagnosis:

100 to 400 mg/day orally in 1 or 2 divided doses.

Usual Adult Dose for Hirsutism:

50 to 200 mg/day orally in 1 or 2 divided doses.

Usual Adult Dose for Congestive Heart Failure:

25 mg/day orally. Increase or decrease based on response and evidence of hyperkalemia.

Usual Adult Dose for Primary Hyperaldosteronism:

Initial dose: 100 mg orally once a day. This dosage may be divided into two daily doses, and increased as tolerated every two to three days to a maximum recommended total daily dose of 400 mg. It is recommended that the dosage be titrated to decrease sodium retention, hypertension, weakness, hypokalemia, and any other signs or symptoms of primary hyperaldosteronism in this patient.

If this patient has an adrenal adenoma or carcinoma, the lowest possible Aldactone® dosage should be given while waiting for surgery. Adrenal hyperplasia, however, usually does not respond to surgery, and chronic spironolactone therapy is recommended.

Patients with adrenal hyperplasia often require other antihypertensive therapy to control their associated hypertension.

What is the dose of Aldactone® (spironolactone) for a child?

Usual Pediatric Dose for Hypertension:

Neonates: 1 to 3 mg/kg/day orally every 12 to 24 hours.

Children: 1.5 to 3.3 mg/kg/day or 60 mg/m2/day orally in divided doses every 6 to 12 hours not to exceed 100 mg/day.

Usual Pediatric Dose for Primary Hyperaldosteronism Diagnosis:

Children: 100 to 400 mg/m2/day orally in 1 to 2 divided doses.

How is Aldactone® (spironolactone) available?

Aldactone® is available in the following dosage forms and strengths:

  • Tablet, film coated: spironolactone 25mg

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Aldactone®, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

 

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: September 10, 2017 | Last Modified: September 10, 2017

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