Generic Name: Albutein Brand Name(s): Generics only. No brands available.

Uses

What is Albutein ® (albumin) used for?

Albutein ® is commonly used for treating:

Albutein ® may be prescribed for other uses; ask your doctor or pharmacist for more information.

How should I take Albutein ® (albumin)?

Albutein ® is injected into a vein in the arm and is always given under direct supervision of a doctor, usually in a hospital or clinic setting. The dose and the rate at which this medication is given varies according to the person’s individual needs for plasma albumin.

How do I store Albutein ® (albumin)?

Albutein ® is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Albutein ® in the bathroom or the freezer. There may be different brands of Albutein ® that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Albutein ® down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Albutein ® (albumin)?

Consult with your doctor or pharmacist, if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with any of active or inactive ingredients of Albutein ® or other medications.
  • You have any other illnesses, disorders, or medical conditions.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using this medication during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking this medication. This medication is pregnancy risk category C, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from Albutein ® (albumin)?

Albutein ® may cause following side effects, such as:

  • Anaphylactic shock
  • Heart failure
  • Pulmonary edema
  • Hypotension
  • Tachycardia
  • Vomiting
  • Urticaria
  • Rash
  • Headache
  • Chills
  • Fever
  • Flushing
  • Nausea

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Albutein ® (albumin)?

Albutein ® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Albutein ® infusions should not be mixed with other infusions of:

  • Packed red blood cells
  • Solutions containing alcohol
  • Solutions containing amino acids
  • Solutions containing protein hydrolysates
  • Whole blood

Does food or alcohol interact with Albutein ® (albumin)?

Albutein ® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Albutein ® (albumin)?

Albutein ® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Especially if you have:

  • Heart failure
  • Kidney failure
  • Stable chronic anemia

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this medication.

What is the dose of Albutein ® (albumin) for an adult?

Albutein ® 5%

Hypovolemia:

Initial dose is 20 g. If hemodynamic stability is not achieved within 15 to 30 minutes, an additional dose may be given. Hemodilution may follow administration of Albutein 5%. Anemia resulting from hemorrhage should be corrected by administration of compatible red blood cells or compatible whole blood.

For acute liver failure: Initial dose is 12 to 25 g. An infusion rate of 1-2 mL per minute is usually indicated.

For renal dialysis: Initial dose should not exceed 20 g and patients should be carefully observed for signs of fluid overload.

Cardiopulmonary bypass procedures:

Initial dose is 25 g. Additional amounts may be administered as clinically indicated.

Hypoalbuminemia:

The recommended dose is 50 to 75 g.

For pre- and post-operative hypoproteinemia: 50 to 75 g. In burns, therapy usually starts with administration of large volumes of crystalloid solution to maintain plasma volume. After 24 hours: initial dose of 25 g and dose adjustment to maintain plasma protein concentration of 2.5 g per 100 mL or a serum protein concentration of 5.2 g per 100 mL.

Third space protein loss due to infection: initial dose is 50 to 100 g. An infusion rate of 1-2 mL per minute is usually indicated in the absence of shock. Treatment should always be guided by hemodynamic response.

Plasma exchange:

The dosage and infusion rate of Albutein 5% infused should be titrated to the volume of plasma removed during the procedure.

Albutein ® 25%

Hypovolemia

Initial dose is 25 g. If hemodynamic stability is not achieved within 15 to 30 minutes, an additional dose may be given. Hemodilution may follow administration of Albutein ® 25%. Anemia resulting from hemorrhage should be corrected by administration of compatible red blood cells or compatible whole blood.

For acute liver failure: initial dose is 12 to 25 g. An infusion rate of 1-2 mL per minute is usually indicated.

For renal dialysis, the initial dose should not exceed 25 g and patients should be carefully observed for signs of fluid overload.

Cardiopulmonary bypass procedures:

Initial dose is 25 g. Additional amounts may be administered as clinically indicated.

Acute nephrosis:

The recommended dose is 25 g together with diuretic once a day for 7-10 days.

Hypoalbuminemia

The recommended dose is 50 to 75 g.

For pre- and post-operative hypoproteinemia: The recommended dose is 50 to 75 g.

In burns, therapy usually starts with administration of large volumes of crystalloid solution to maintain plasma volume. After 24 hours, initial dose is 25 g and dose adjustment to maintain plasma protein concentration of 2.5 g per 100 mL or a serum protein concentration of 5.2 g per 100 mL.

Third space protein loss due to infection: initial dose is 50 to 100 g. An infusion rate of 1-2 mL per minute is usually indicated in the absence of shock. Treatment should always be guided by hemodynamic response.

Ovarian hyperstimulation syndrome:

The recommended dose is 50 g to 100 g over 4 hours and repeated at 4-12 hour intervals as necessary, when infusion of normal saline fails to achieve or maintain hemodynamic stability and urine output

Adult respiratory distress syndrome (ARDS):

The recommended dose is 25 g over 30 minutes and repeated at 8 hours for 3 days, if necessary.

Prevention of central volume depletion after paracentesis due to cirrhotic ascites:

The recommended dose is 8 g for every 1000 mL of ascitic fluid removed.

What is the dose of Albutein ® (albumin) for a child?

Albutein ® 25%

Neonatal hyperbilirubinemia:

The recommended dose is 1 g per kilogram body weight prior to or during exchange transfusion.

How is Albutein ® (albumin) available?

Albutein ® is available in the following dosage forms and strengths:

  • Albutein ® 5% Solution USP is available as a solution containing 5% human albumin.
  • Albutein ® 25% Solution USP is available as a solution containing 25% human albumin.

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of medication, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Review Date: June 7, 2017 | Last Modified: June 7, 2017

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