Aflibercept

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Generic Name: Aflibercept Brand Name(s): Generics only. No brands available. Avability: Rx Pregnancy Category: N

Uses

What is Aflibercept used for?

Aflibercept is used to treat certain serious eye conditions (such as wet age-related macular degeneration – wet AMD, macular edema following central retinal vein occlusion, diabetic macular edema). This medication can help preserve vision and prevent blindness. Aflibercept belongs to a class of drugs known as growth factor inhibitors. It works by slowing the growth of abnormal new blood vessels in the eye and decreasing leakage from these blood vessels.

How should I take Aflibercept?

This medication is prepared and given by injection into the affected eye(s) by a health care professional. The affected eye is numbed before each injection. After the injection, you will remain in the doctor’s office for a while, and your eye(s) and vision will be monitored.

The dosage and treatment schedule are based on your medical condition and response to treatment. Your doctor will give you regularly scheduled injections, usually every 1 or 2 months. For the best effect, carefully follow your doctor’s directions. Use this medication regularly to get the most benefit from it.

Tell your doctor if your condition worsens.

How do I store Aflibercept?

Aflibercept is best stored in the refrigerator. To prevent drug damage, do not freeze. There may be different brands of Aflibercept that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Aflibercept down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Aflibercept?

Before taking aflibercept, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: a current eye infection.

This drug may cause blurred vision. Do not drive, use machinery, or do any activity that requires clear vision until you are sure you can perform such activities safely.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits, and ask your doctor which reliable forms of birth control to use during and for 3 months after stopping treatment. If you become pregnant or think you may be pregnant, tell your doctor right away.

It is unknown if this medication passes into breast milk. Consult your doctor before breast-feeding.

Is it safe during pregnancy or breast-feeding?

There are no adequate studies in women for determining risk when using this Aflibercept during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Aflibercept. Aflibercept is pregnancy risk category N according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown

Side effects

What side effects can occur from Aflibercept?

Injection site pain, feeling as if something is in the eye, or increased tears may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Tell your doctor right away if you have any serious side effects, including: floaters (blurry shapes that seem to float in front of your eyes), swollen eyelids.

Get medical help right away if you have any very serious side effects, including: chest/jaw/left arm pain, shortness of breath, unusual sweating, weakness on one side of the body, slurred speech, confusion.

This medication may rarely increase your risk for developing certain serious eye conditions (endophthalmitis or retinal detachment). Get medical help right away if you notice any of these symptoms in the affected eye(s): pain, redness, sensitivity to light, blurred vision, sudden change in vision, loss of vision.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Aflibercept?

Some products that may interact with this drug include: products applied to the eye (such as eye drops).

Aflibercept may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Aflibercept?

Aflibercept may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Aflibercept?

Aflibercept may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this Aflibercept.

What is the dose of Aflibercept for an adult?

Usual Adult Dose for Macular Degeneration

2 mg via intravitreal injection every 4 weeks for the first 12 weeks, then 2 mg via intravitreal injection every 8 weeks

-Some patients may need to continue with every 4-week dosing after the first 12 weeks

Usual Adult Dose for Macular Edema

Macular Edema following Retinal Vein Occlusion (RVO):

2 mg via intravitreal injection every 4 weeks

Diabetic Macular Edema (DME):

2 mg via intravitreal injection every 4 weeks for the first 5 injections (20 weeks), then 2 mg via intravitreal injection every 8 weeks

-Some patients may need to continue with every 4-week dosing after the first 20 weeks

Diabetic Retinopathy (DR) in Patients with DME:

2 mg via intravitreal injection every 4 weeks for the first 5 injections (20 weeks), then 2 mg via intravitreal injection every 8 weeks

-Some patients may need to continue with every 4-week dosing after the first 20 weeks

Renal Dose Adjustments

No adjustment recommended

Liver Dose Adjustments

No adjustment recommended

What is the dose of Aflibercept for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Aflibercept available?

Aflibercept is available in the following dosage forms and strengths:

  • Intraocular solution.

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Aflibercept, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: November 14, 2018 | Last Modified: November 14, 2018

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