Generic Name: Advair Brand Name(s): Generics only. No brands available.

Uses

What is Advair® (fluticasone and salmeterol) used for?

Advair® is commonly used to prevent asthma attacks. It is also used to prevent flare-ups or worsening of chronic obstructive pulmonary disease (COPD) associated with chronic bronchitis and/or emphysema.

In people with COPD, Advair® is for long-term treatment. In people with asthma, this medicine is for short-term treatment until symptoms are well controlled with other medicines.

Advair® is for use in adults and children who are at least 4 years old. Advair® HFA is for use in adults and children who are at least 12 years old.

How should I take Advair® (fluticasone and salmeterol)?

Use Advair® exactly as it was prescribed for you. Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended. Using too much of this medicine can cause life-threatening side effects.

Advair® is not a rescue medicine. It will not work fast enough to treat an asthma attack. Use only a fast acting inhalation medicine for an asthma attack.

Seek medical attention if you think your medications are not working as well.

Advair® Diskus is a powder form of fluticasone and salmeterol that comes with a special inhaler device pre-loaded with blister packs containing measured doses of the medicine. The device opens and loads a blister each time you use the inhaler. This device is not to be used with a spacer.

Advair® HFA is an aerosol form of fluticasone and salmeterol that comes in a canister that is used with an actuator inhaler device. Use only the inhaler device provided with Advair HFA.

Shake the Advair® HFA inhaler for at least 5 seconds before each spray.

To reduce the chance of developing a yeast infection in your mouth, rinse with water after using your inhaler. Do not swallow.

Keep track of the number of sprays you have used and throw away the Advair® HFA canister after 120 sprays, even if it feels like there is still medicine in it.

Your doctor will need to check your lung function on a regular basis. Once your asthma is under control, your doctor may want you to stop using this medicine. Keep all follow-up appointments and do not stop using the medicine unless your doctor tells you to.

Your dose needs may change if you have surgery, are ill, are under stress, or have recently had an asthma attack. Do not change your medication dose or schedule without your doctor’s advice.

If you also use an oral steroid medication, you should not stop using it suddenly. Follow your doctor’s instructions about tapering your dose.

While using Advair®, your vision and your bone mineral density may need to be checked often.

Seek medical attention if your breathing problems do not improve, or if your symptoms get worse quickly. If you use a peak flow meter at home, call your doctor if your numbers are lower than normal.

Throw the inhaler device away 1 month after you took it out of the foil pouch, or if the dose indicator shows a zero (even if it feels like there is still medicine inside).

Once your asthma is under control, your doctor may want you to stop using this medicine. Keep all follow-up appointments and do not stop using the medicine unless your doctor tells you to.

How do I store Advair® (fluticasone and salmeterol)?

Advair® is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Advair® in the bathroom or the freezer. There may be different brands of Advair® that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Advair® down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Advair® (fluticasone and salmeterol)?

Before using this drug, tell your doctor if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with any of active or inactive ingredients of Advair® or other medications.
  • You have any other illnesses, disorders, or medical conditions.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using Advair® during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Advair®. Advair® is pregnancy risk category C, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from Advair® (fluticasone and salmeterol)?

Get emergency medical help if you have signs of an allergic reaction to Advair®: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • Wheezing, choking, or other breathing problems after using this medicine
  • Chest pain, fast or uneven heart beats, restless feeling, tremors
  • Severe headache, pounding in your neck or ears, nosebleed
  • Fever, chills, swollen glands, mouth sores, skin sores, flu symptoms, cough with yellow or green mucus
  • Blurred vision, tunnel vision, eye pain, or seeing halos around lights
  • High blood sugar – increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin
  • Low potassium – confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, muscle weakness or limp feeling
  • Signs of a hormonal disorder – worsening tiredness or muscle weakness, feeling light-headed, anxiety, feeling irritable, nausea, vomiting, loss of appetite, diarrhea, weight loss, weight gain, slow wound healing

Common side effects may include:

  • Headache, muscle pain, bone pain, back pain
  • Nausea, vomiting
  • Throat irritation, white patches in the mouth or throat
  • Cold symptoms such as stuffy nose, sneezing, sore throat
  • Ongoing cough, hoarseness or deepened voice

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Advair® (fluticasone and salmeterol)?

Advair® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Products that may interact with this drug are:

  • An antidepressant, heart or blood pressure medicine, a diuretic or “water pill”
  • Antifungal medicine such as ketoconazole
  • Ritonavir (Norvir) or lopinavir/ritonavir (Kaletra)

Does food or alcohol interact with Advair® (fluticasone and salmeterol)?

Advair® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Advair® (fluticasone and salmeterol)?

Advair® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Health conditions that may interact with this drug are:

  • A food or drug allergy
  • Heart disease or high blood pressure
  • Epilepsy or other seizure disorder
  • Any type of infection
  • A weak immune system
  • Diabetes
  • Glaucoma
  • Tuberculosis
  • Osteoporosis
  • A thyroid disorder
  • Liver disease

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Advair® (fluticasone and salmeterol).

What is the dose of Advair® (fluticasone and salmeterol) for an adult?

Usual Adult Dose of Advair for Chronic Obstructive Pulmonary Disease – Maintenance:

Fluticasone 250 mcg-salmeterol 50 mcg (1 inhalation) orally twice a day, approximately 12 hours apart.

Usual Adult Dose of Advair for Asthma – Maintenance:

Inhalation Powder:

  • 1 inhalation of fluticasone 100 mcg-salmeterol 50 mcg, fluticasone 250 mcg-salmeterol 50 mcg, or fluticasone 500 mcg-salmeterol 50 mcg orally twice a day.
  • Maximum dose: Fluticasone 500 mcg-salmeterol 50 mcg orally twice a day.

Inhalation Aerosol:

  • 2 inhalations of fluticasone 45 mcg-salmeterol 21 mcg, fluticasone 115 mcg-salmeterol 21 mcg, or fluticasone 230 mcg-salmeterol 21 mcg orally twice a day.
  • Maximum dose: Fluticasone 230 mcg-salmeterol 31 mcg orally twice a day

What is the dose of Advair® (fluticasone and salmeterol) for a child?

Usual Pediatric Dose of Advair for Asthma – Maintenance:

Inhalation Powder:

Less than 4 years: Not recommended.

4 years to 11 years: Fluticasone 100 mcg-salmeterol 50 mcg (1 inhalation) orally twice a day.

12 years or older:

  • 1 inhalation of fluticasone 100 mcg-salmeterol 50 mcg, fluticasone 250 mcg-salmeterol 50 mcg, or fluticasone 500 mcg-salmeterol 50 mcg orally twice a day.
  • Maximum dose: Fluticasone 500 mcg-salmeterol 50 mcg orally twice a day.

Inhalation Aerosol:

Less than 12 years: Use is not approved.

12 years and older: 2 inhalations of fluticasone 45 mcg-salmeterol 21 mcg, fluticasone 115 mcg-salmeterol 21 mcg, or fluticasone 230 mcg-salmeterol 21 mcg orally twice a day.

How is Advair® (fluticasone and salmeterol) available?

Advair® is available in the following dosage forms and strengths:

  • Aerosol, metered: fluticasone propionate 45ug, salmeterol xinafoate 21ug

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Advair®, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: August 4, 2017 | Last Modified: August 4, 2017

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