Generic Name: Act HIB Brand Name(s): Generics only. No brands available.

Uses

What is Act HIB® (Haemophilus b polysaccharide conjugate vaccine) used for?

Act HIB® is a vaccine. It works by causing your immune system to produce antibodies that help to prevent infection caused by H. influenza bacteria.

It is commonly used for children 2 months through 5 years old.

How should I take Act HIB® (Haemophilus b polysaccharide conjugate vaccine)?

Act HIB® is usually administered as an injection at your doctor’s office, hospital, or clinic. Ask your doctor any questions that you may have about Act HIB®.

How do I store Act HIB® (Haemophilus b polysaccharide conjugate vaccine)?

Act HIB® is handled and stored by a health care provider. If you use this vaccine at home, store Act HIB® as directed by your doctor.

Precautions & warnings

What should I know before using Act HIB® (Haemophilus b polysaccharide conjugate vaccine)?

Before using this drug, there is some important safety information that you may notice:

  • It is important that your child completes the vaccination series.
  • If your child has a fever or an infection, your doctor may delay giving this vaccine.
  • Make sure your healthcare provider has a complete record of your child’s vaccinations and is aware of your child’s current health status.
  • Act HIB® is not approved for use in infants younger than 6 weeks old or children older than 5 years old. Safety and effectiveness in these age groups have not been confirmed.
  • Tell your doctor if your child has had an allergic reaction to a vaccine in the past.
  • Tell your doctor if you develop Guillain-Barré syndrome after receiving a tetanus-containing vaccine in the past.

Is it safe during pregnancy or breastfeeding?

There isn’t enough information about the safety of using this medication during pregnancy and breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking this medication.

Side effects

What side effects can occur from Act HIB® (Haemophilus b polysaccharide conjugate vaccine)?

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most common side effects persist or become bothersome:

  • Fever
  • Irritability
  • Redness, tenderness, pain, or swelling at the injection site
  • Sleepiness

Seek medical attention right away if any of these severe side effects occur:

  • Rash
  • Hives
  • Difficulty breathing
  • Tightness in the chest
  • Swelling of the mouth, face, lips, or tongue
  • Burning, numbness, or tingling
  • Fainting
  • Hardening or lump at the injection site
  • Seizures
  • Vision changes

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Act HIB® (Haemophilus b polysaccharide conjugate vaccine)?

Act HIB® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Especially when your child is taking:

  • Anticoagulants (e.g., warfarin)
  • Radiation treatments
  • Medicine suppressing your immune system, such as chemotherapy (e.g., cyclophosphamide) or corticosteroids (e.g., prednisone)

Does food or alcohol interact with Act HIB® (Haemophilus b polysaccharide conjugate vaccine)?

Act HIB® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Act HIB® (Haemophilus b polysaccharide conjugate vaccine)?

Act HIB® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

These health conditions are:

  • Immune system problems (e.g., weakened immune system) or HIV infection
  • A bleeding disorder or a reduced blood platelet count (thrombocytopenia)
  • A fever
  • Cancer

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using Act HIB® (Haemophilus b polysaccharide conjugate vaccine).

What is the dose of Act HIB® (Haemophilus b polysaccharide conjugate vaccine) for an adult?

H. influenza Type B Immunization

It is not indicated for routine immunization in otherwise healthy adults.

It is indicated for adults with functional or anatomic asplenia (including sickle cell disease) or is undergoing elective splenectomy.

One dose of HIB vaccine should be administered if HIB vaccine not previously received.

HIB vaccination should be given ≥14 days before splenectomy.

Complement deficiency

Indicated for adults with persistent complement component deficiencies.

One dose of HIB vaccine should be administered if HIB vaccine not previously received.

Post-HSCT Recipients

Recipients of a hematopoietic stem cell transplant (HSCT) should be vaccinated with a 3-dose regimen 6 to 12 months after a successful transplant, regardless of vaccination history.

At least 4 weeks should separate doses.

Dosing Considerations

Not recommended for adults with HIV infection since their risk for HIB infection is low, unless another risk factor is present (i.e., asplenia, complement deficiency, HSCT recipient).

What is the dose of Act HIB® (Haemophilus b polysaccharide conjugate vaccine) for a child

H. influenza Type B Immunization

IM injection is indicated for routine immunization in children aged 2 months to 15 months and up to 5 years for catch up vaccination.

Primary series (6 weeks to 12 months) are 2 or 3 doses.

Booster is 3rd or 4th dose between 12-15 months.

PRP-OMP

(Monovalent vaccine; polyribosylribotol phosphate (PRP) conjugated to outer membrane protein (OMP) complex from Neisseria meningitides)

PEDvaxHIB are 2 and 4 months (primary series); 12-15 months (booster).

PRP-T

(Monovalent vaccines; polyribosylribotol phosphate (PRP) conjugated to tetanus toxoid (T))

ActHIB, Hiberix are 0.5 ml IM as 4-dose series at 2, 4, and 6 months (primary series) and between 12-15 months (booster).

Combination vaccines

PRP-OMP-HepB (Comvax) are 2 and 4 months (primary series); 12-15 months (booster).

DTap-IPV/PRP-T (Pentacel) are 2, 4, and 6 months (primary series); 12-15 months (booster).

MenCY-PRP-T (MenHibRix) are 2, 4, and 6 months (primary series); 12-15 months (booster).

Considered fully immunized if

  • At least 1 dose after age 14 months
  • 2 doses between 12-14 months
  • >2 doses during first year of life followed by booster when older than 1 year

Immunosuppressed individuals

  • Consider administering in patients 5 years or older if not already vaccinated and are immunosuppressed (e.g., sickle cell disease, leukemia, HIV or anatomic/functional asplenia).

Dosing Considerations

PRP-T: Polyribosylribotol phosphate conjugated to tetanus toxoid.

OMP: Outer membrane protein complex from Neisseria meningitides.

Minimum age for vaccination is 6 weeks old for PRP-T (ActHIB), DTaP-IPV/Hib (Pentacel), and Hib-Mency (MenHibrix), or PRP-OMP (PedvaxHIB, Comvax).

Minimum age for vaccination is 12 months old for PRP-T (Hiberix).

Act HIB®: Reconstituted with 0.4% NaCl diluent is indicated for active immunization of children aged 2 months through 5 years for prevention of invasive disease caused by Haemophilus influenza type b.

TriHIBit: Act HIB® reconstituted with Tripedia (DTP) vaccine creates TriHIBit vaccine; it is indicated for the active immunization of children aged 15 through 18 months for prevention of invasive disease caused by Haemophilus influenza type b and diphtheria, tetanus and pertussis.

How is Act HIB® (Haemophilus b polysaccharide conjugate vaccine) available?

Act HIB® is available in the following dosage forms and strengths:

  • Injection: 10mcg Haemophilus b, 25mcg tetanus toxoid/0.5ml

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Act HIB®, ask your doctor as soon as possible.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: March 18, 2017 | Last Modified: March 18, 2017

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