Generic Name: Acetohydroxamic Acid Brand Name(s): Generics only. No brands available. Avability: Rx Pregnancy Category: C

Uses

What is Acetohydroxamic Acid used for?

Acetohydroxamic Acid is used with antibiotics and/or surgery to treat types of bladder infections that are caused by certain bacteria. These bacteria cause the level of ammonia in the urine to become too high. This effect can lead to a certain type of kidney stone (struvite). This medication works by stopping the bacteria from making the ammonia. The decreased levels of ammonia can slow the growth of the kidney stones and make the antibiotic work better on your infection.

How should I take Acetohydroxamic Acid?

Take this medication by mouth on an empty stomach, usually 3 to 4 times daily or as directed by your doctor.

Dosage is based on your medical condition, weight, and response to treatment. Do not take more than 1500 milligrams a day.

Use this medication regularly to get the most benefit from it. To help you remember, use it at the same times each day.

Tell your doctor if your condition persists or worsens.

How do I store Acetohydroxamic Acid?

Acetohydroxamic Acid is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Acetohydroxamic Acid in the bathroom or the freezer. There may be different brands of Acetohydroxamic Acid that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Acetohydroxamic Acid down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Acetohydroxamic Acid?

Before taking acetohydroxamic acid, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, blood clots, blood/bone marrow disorders (e.g., anemia), regular alcohol use.

This medication must not be used during pregnancy. It may harm an unborn baby. Therefore, it is important to prevent pregnancy while taking this medication. Consult your doctor for more details and to discuss the use of reliable forms of birth control (e.g., condoms, birth control pills) while taking this medication. If you become pregnant or think you may be pregnant, tell your doctor right away.

This drug may pass into breast milk and may have undesirable effects on a nursing infant. Consult your doctor before breast-feeding.

Is it safe during pregnancy or breast-feeding?

There are no adequate studies in women for determining risk when using this Acetohydroxamic Acid during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Acetohydroxamic Acid. Acetohydroxamic Acid is pregnancy risk category X according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown

Side effects

What side effects can occur from Acetohydroxamic Acid?

Headache, nausea, vomiting, stomach upset, unusual hair loss, or loss of appetite may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Tell your doctor right away if any of these unlikely but serious side effects occur: fast/pounding heartbeat, unusual tiredness, weakness, dark urine, mental/mood changes (e.g., nervousness, depression), shaking (tremor).

Tell your doctor right away if any of these rare but very serious side effects occur: pain/redness/swelling of arms or legs, easy bruising/bleeding, signs of infection (e.g., fever, persistent sore throat).

Seek immediate medical attention if any of these rare but very serious side effects occur: trouble breathing, chest pain.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Acetohydroxamic Acid?

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: iron-containing products taken by mouth (e.g., supplements, multivitamins).

Acetohydroxamic Acid may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Acetohydroxamic Acid?

Acetohydroxamic Acid may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

Avoid alcoholic beverages while taking this medication because alcohol with acetohydroxamic acid may cause a skin reaction (e.g., flushing, redness, warmth, tingling). The reaction usually appears 30 to 45 minutes after having alcohol and disappears 30 to 60 minutes later.

What health conditions may interact with Acetohydroxamic Acid?

Acetohydroxamic Acid may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this Acetohydroxamic Acid.

What is the dose of Acetohydroxamic Acid for an adult?

Usual Adult Dose for Urinary Tract Infection

Starting dose: 12 mg/kg/day administered at 6 to 8 hour intervals at a time when the stomach is empty.

Then progress to one tablet orally 3 to 4 times a day in a total daily dose of 10 to 15 mg/kg/day.

The maximum daily dose should be no more than 1.5 grams, regardless of body weight.

What is the dose of Acetohydroxamic Acid for a child?

Usual Pediatric Dose for Urinary Tract Infection

Children with chronic, recalcitrant, urea-splitting urinary infection may benefit from treatment with acetohydroxamic acid. However, detailed studies involving dosage and dose intervals in children have not been established.

Children have tolerated a dose of 10 mg/kg/day, taken in two or three divided doses, satisfactorily for periods up to one year. Therefore, an initial dose of 10 mg/kg/day orally is recommended.

Close monitoring of the patient’s clinical condition and hematologic status is recommended. Titration of the dose to higher or lower levels may be required to obtain an optimum therapeutic effect and/or to reduce the risk of side effects.

How is Acetohydroxamic Acid available?

Acetohydroxamic Acid is available in the following dosage forms and strengths:

  • Oral tablet.

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Acetohydroxamic Acid, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

 

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: November 9, 2018 | Last Modified: November 9, 2018

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