Acetaminophen-Oxycodone

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Generic Name: Acetaminophen-Oxycodone Brand Name(s): Generics only. No brands available. Avability: Rx Pregnancy Category: C (immediate-release); N (extended-release)

Uses

What is Acetaminophen-Oxycodone used for?

Acetaminophen-Oxycodone is a combination medication used to help relieve severe pain. It contains a opioid (narcotic) pain reliever (oxycodone) and a non-opioid pain reliever (acetaminophen). Oxycodone works in the brain to change how your body feels and responds to pain. Acetaminophen gives added pain relief and can also reduce a fever.

How should I take Acetaminophen-Oxycodone?

Do not change brands of this medication unless specifically directed by your doctor. If you take a different brand, you may need to take a different amount or take it on a different schedule.

Take this medication by mouth as directed by your doctor, usually twice a day (12 hours apart). Do not pre-soak, lick, or otherwise wet the tablet before placing it in your mouth, since the tablet may swell and become sticky when wet. If your dose is for more than one tablet, you should take one tablet at a time. Take each tablet with enough water to make sure you completely swallow it right after placing it in your mouth. This tablet should not be given through a tube in the throat, stomach, or gut, since it may swell and block the tube.

You may take this drug with or without food. If you have nausea, it may help to take this drug with food. Ask your doctor or pharmacist about other ways to decrease nausea (such as lying down for 1 to 2 hours with as little head movement as possible).

The dosage is based on your medical condition and response to treatment. Do not increase your dose, or take it more often or for a longer time than prescribed.

Pain medications work best if they are used as the first signs of pain occur. If you wait until the pain has worsened, the medication may not work as well.

Before you start taking this medication, ask your doctor or pharmacist if you should stop or change how you use your other opioid medication(s). Other pain relievers (such as ibuprofen, naproxen) may also be prescribed. Ask your doctor or pharmacist about using oxycodone safely with other drugs.

This medication may cause withdrawal reactions, especially if it has been used regularly for a long time or in high doses. In such cases, withdrawal symptoms (such as restlessness, watering eyes, runny nose, nausea, sweating, muscle aches) may occur if you suddenly stop using this medication. To prevent withdrawal reactions, your doctor may reduce your dose gradually. Ask your doctor or pharmacist for more details, and report any withdrawal reactions right away.

When this medication is used for a long time, it may not work as well. Talk with your doctor if this medication stops working well.

Though it helps many people, this medication may sometimes cause addiction. This risk may be higher if you have a substance use disorder (such as overuse of or addiction to drugs/alcohol). Take this medication exactly as prescribed to lower the risk of addiction. Ask your doctor or pharmacist for more details.

Tell your doctor if your pain persists or worsens.

How do I store Acetaminophen-Oxycodone?

Acetaminophen-Oxycodone is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Acetaminophen-Oxycodone in the bathroom or the freezer. There may be different brands of Acetaminophen-Oxycodone that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Acetaminophen-Oxycodone down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Acetaminophen-Oxycodone?

Before taking this medication, tell your doctor or pharmacist if you are allergic to oxycodone or acetaminophen; or to other opioids (such as morphine, codeine); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: trouble with swallowing, brain disorders (such as head injury, tumor, seizures), breathing problems (such as asthma, sleep apnea, chronic obstructive pulmonary disease-COPD), kidney disease, liver disease, mental/mood disorders (such as confusion, depression, thoughts of suicide), personal or family history of a substance use disorder (such as overuse of or addiction to drugs/alcohol), stomach/intestinal problems (such as blockage, constipation, diarrhea due to infection, paralytic ileus), gallbladder disease, disease of the pancreas (pancreatitis), difficulty urinating (such as due to enlarged prostate).

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Older adults may be more sensitive to the side effects of this drug, especially confusion, dizziness, drowsiness, and slow/shallow breathing.

During pregnancy, this medication should be used only when clearly needed. It may harm an unborn baby. Discuss the risks and benefits with your doctor.

This drug passes into breast milk and may have undesirable effects on a nursing infant. Tell the doctor right away if your baby develops unusual sleepiness, difficulty feeding, or trouble breathing. Consult your doctor before breast-feeding.

Is it safe during pregnancy or breast-feeding?

There are no adequate studies in women for determining risk when using this Acetaminophen-Oxycodone during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Acetaminophen-Oxycodone. Acetaminophen-Oxycodone is pregnancy risk category C (immediate-release) and N (extended-release) according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown

Side effects

What side effects can occur from Acetaminophen-Oxycodone?

Nausea, vomiting, constipation, lightheadedness, dizziness, or drowsiness may occur. Some of these side effects may decrease after you have been using this medication for a while. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

To prevent constipation, eat a diet adequate in fiber, drink plenty of water, and exercise. Consult your pharmacist for help in selecting a laxative (such as a stimulant type with stool softener).

To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.

Tell your doctor right away if you have any serious side effects, including: mental/mood changes (such as agitation, confusion, hallucinations), severe stomach/abdominal pain, difficulty urinating, signs of your adrenal glands not working well (such as loss of appetite, unusual tiredness, weight loss).

Get medical help right away if you have any very serious side effects, including: fainting, seizure, slow/shallow breathing, severe drowsiness/difficulty waking up.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Acetaminophen-Oxycodone?

Some products that may interact with this drug include: certain pain medications (mixed opioid agonist-antagonists such as pentazocine, nalbuphine, butorphanol), naltrexone.

The risk of serious side effects (such as slow/shallow breathing, severe drowsiness/dizziness) may be increased if this medication is taken with other products that may also cause drowsiness or breathing problems. Tell your doctor or pharmacist if you are taking other products such as other opioid pain or cough relievers (such as codeine, hydrocodone), alcohol, marijuana, drugs for sleep or anxiety (such as alprazolam, lorazepam, zolpidem), muscle relaxants (such as carisoprodol, cyclobenzaprine), or antihistamines (such as cetirizine, diphenhydramine).

Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely.

Other medications can affect the removal of oxycodone from your body, which may affect how oxycodone works. Examples include azole antifungals (such as ketoconazole), macrolide antibiotics (such as erythromycin), HIV medications (such as ritonavir), rifamycins (such as rifabutin, rifampin), certain drugs used to treat seizures (such as carbamazepine, phenytoin), among others.

This medication may interfere with certain laboratory tests (including amylase/lipase levels), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.

Acetaminophen-Oxycodone may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Acetaminophen-Oxycodone?

Acetaminophen-Oxycodone may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

This drug may make you dizzy or drowsy. Alcohol or marijuana can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Avoid alcoholic beverages. Talk to your doctor if you are using marijuana.

What health conditions may interact with Acetaminophen-Oxycodone?

Acetaminophen-Oxycodone may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this Acetaminophen-Oxycodone.

What is the dose of Acetaminophen-Oxycodone for an adult?

Usual Adult Dose for Pain

Immediate-release:

Oxycodone 2.5 mg/acetaminophen 300 or 325 mg: 1 to 2 tablets every 6 hours

Maximum dose: 12 tablets in 24 hours

Oxycodone 5 mg/acetaminophen 300 or 325 mg: 1 tablet orally every 6 hours as needed for pain

Maximum dose: 12 tablets in 24 hours

Oxycodone 7.5 mg/acetaminophen 300 or 325 mg: 1 tablet orally every 6 hours as needed for pain

Maximum dose: 8 tablets in 24 hours

Oxycodone 10 mg/acetaminophen 300 or 325 mg: 1 tablet orally every 6 hours as needed for pain

Maximum dose: 6 tablets in 24 hours

Oral Solution: Oxycodone 5 mg/acetaminophen 325 mg per 5 mL:

Usual dose: Oxycodone 5 mg/acetaminophen 325 mg (5 mL) orally every 6 hours as needed for pain

Maximum dose: Oxycodone 60 mg/acetaminophen 3900 mg (60 mL) in 24 hours

-Verify dose in mg and mL prior to administration

Extended-Release (Er) Dosing:

As First Opioid Analgesic: 2 tablets orally every 12 hours (each ER tablet contains oxycodone 7.5 mg/acetaminophen 325 mg)

-The second dose may be administered as early as 8 hours after initial dose if needed; however, subsequent doses should be administered every 12 hours

Use: For the management of acute pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate.

Renal Dose Adjustments

Immediate-release:

-Use with caution; therapy should be initiated with a lower than usual dose; titrate carefully

Extended-release (ER):

Initial dose: Oxycodone 7.5 mg/Acetaminophen 325 mg ER: 1 tablet orally every 12 hours; adjust does as needed

Liver Dose Adjustments

Immediate-release:

-Use with caution; therapy should be initiated with a lower than usual dose; titrate carefully

Extended-release (ER):

Initial dose: Oxycodone 7.5 mg/Acetaminophen 325 mg ER: 1 tablet orally every 12 hours; adjust dose as needed

Dose Adjustments

Elderly, Cachectic, or Debilitated Patients: Use with caution generally starting at the low end of the dosing range, titrate dose slowly while monitoring closely for signs of central nervous system or respiratory depression.

What is the dose of Acetaminophen-Oxycodone for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Acetaminophen-Oxycodone available?

Acetaminophen-Oxycodone is available in the following dosage forms and strengths:

  • Oral capsule,
  • Oral tablet,
  • Oral solution,
  • Oral tablet, extended release.

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Acetaminophen-Oxycodone, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Review Date: November 9, 2018 | Last Modified: November 9, 2018

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