Generic Name: Acetaminophen-Hydrocodone Brand Name(s): Generics only. No brands available. Avability: Rx Pregnancy Category: C

Uses

What is Acetaminophen-Hydrocodone used for?

Acetaminophen-Hydrocodone is a combination medication used to relieve moderate to severe pain. It contains an opioid (narcotic) pain reliever (hydrocodone) and a non-opioid pain reliever (acetaminophen). Hydrocodone works in the brain to change how your body feels and responds to pain. Acetaminophen can also reduce a fever.

This product is not recommended for use in children younger than 6 years due to an increased risk of serious side effects (such as slow/shallow breathing).

How should I take Acetaminophen-Hydrocodone ?

Take this medication by mouth as directed by your doctor. You may take this drug with or without food. If you have nausea, it may help to take this drug with food. Ask your doctor or pharmacist about other ways to decrease nausea (such as lying down for 1 to 2 hours with as little head movement as possible).

If you are using a liquid form of this medication, use a medication measuring device to carefully measure the prescribed dose. Do not use a household spoon because you may not get the correct dose.

The dosage is based on your medical condition and response to treatment. In children, the dosage is also based on weight. Do not increase your dose, take the medication more frequently, or take it for a longer time than prescribed. Properly stop the medication when so directed.

Pain medications work best if they are used as the first signs of pain occur. If you wait until the pain has worsened, the medication may not work as well.

If you have ongoing pain (such as due to cancer), your doctor may direct you to also take long-acting opioid medications. In that case, this medication might be used for sudden (breakthrough) pain only as needed. Other pain relievers (such as ibuprofen, naproxen) may also be prescribed. Ask your doctor or pharmacist about using this product safely with other drugs.

This medication may cause withdrawal reactions, especially if it has been used regularly for a long time or in high doses. In such cases, withdrawal symptoms (such as restlessness, watering eyes, runny nose, nausea, sweating, muscle aches) may occur if you suddenly stop using this medication. To prevent withdrawal reactions, your doctor may reduce your dose gradually. Ask your doctor or pharmacist for more details, and report any withdrawal reactions right away.

When this medication is used for a long time, it may not work as well. Talk with your doctor if this medication stops working well.

Though it helps many people, this medication may sometimes cause addiction. This risk may be higher if you have a substance use disorder (such as overuse of or addiction to drugs/alcohol). Take this medication exactly as prescribed to lower the risk of addiction. Ask your doctor or pharmacist for more details. Tell your doctor if your pain persists or worsens.

How do I store Acetaminophen-Hydrocodone ?

Acetaminophen-Hydrocodone  is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Acetaminophen-Hydrocodone  in the bathroom or the freezer. There may be different brands of Acetaminophen-Hydrocodone  that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Acetaminophen-Hydrocodone  down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Acetaminophen-Hydrocodone ?

Before taking this medication, tell your doctor or pharmacist if you are allergic to it; or to other opioids (such as hydromorphone, morphine, codeine); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: brain disorders (such as head injury, tumor, seizures), breathing problems (such as asthma, sleep apnea, chronic obstructive pulmonary disease-COPD), kidney disease, liver disease, mental/mood disorders (such as confusion, depression, thoughts of suicide), personal or family history of a substance use disorder (such as overuse of or addiction to drugs/alcohol), stomach/intestinal problems (such as blockage, constipation, diarrhea due to infection, paralytic ileus), difficulty urinating (such as due to enlarged prostate), gallbladder disease, disease of the pancreas (pancreatitis).

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Children may be more sensitive to the side effects of this drug, especially slow/shallow breathing. Older adults may be more sensitive to the side effects of this drug, especially confusion, dizziness, drowsiness, and slow/shallow breathing.

During pregnancy, this medication should be used only when clearly needed. It may harm an unborn baby. Discuss the risks and benefits with your doctor.

This medication passes into breast milk and may have undesirable effects on a nursing infant. Tell the doctor right away if your baby develops unusual sleepiness, difficulty feeding, or trouble breathing. Consult your doctor before breast-feeding.

Is it safe during pregnancy or breast-feeding?

There are no adequate studies in women for determining risk when using this Acetaminophen-Hydrocodone  during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Acetaminophen-Hydrocodone . Acetaminophen-Hydrocodone  is pregnancy risk category C according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown

Side effects

What side effects can occur from Acetaminophen-Hydrocodone ?

Nausea, vomiting, constipation, lightheadedness, dizziness, or drowsiness may occur. Some of these side effects may decrease after you have been using this medication for a while. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. To prevent constipation, eat a diet adequate in fiber, drink plenty of water, and exercise. Consult your pharmacist for help in selecting a laxative (such as a stimulant type with stool softener).

To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.

Tell your doctor right away if you have any serious side effects, including: mental/mood changes (such as agitation, confusion, hallucinations), stomach/abdominal pain, difficulty urinating, signs of your adrenal glands not working well (such as loss of appetite, unusual tiredness, weight loss).

Get medical help right away if you have any very serious side effects, including: fainting, seizure, slow/shallow breathing, severe drowsiness/difficulty waking up.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Acetaminophen-Hydrocodone ?

Some products that may interact with this drug include: certain pain medications (mixed opioid agonist/antagonists such as pentazocine, nalbuphine, butorphanol), naltrexone.

The risk of serious side effects (such as slow/shallow breathing, severe drowsiness/dizziness) may be increased if this medication is taken with other products that may also cause drowsiness or breathing problems. Tell your doctor or pharmacist if you are taking other products such as other opioid pain or cough relievers (such as codeine, oxycodone), alcohol, marijuana, drugs for sleep or anxiety (such as alprazolam, lorazepam, zolpidem), muscle relaxants (such as carisoprodol, cyclobenzaprine), or antihistamines (such as cetirizine, diphenhydramine).

Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely.

Other medications can affect the removal of hydrocodone/acetaminophen from your body, which may affect how hydrocodone/acetaminophen works. Examples include azole antifungals (such as ketoconazole), macrolide antibiotics (such as erythromycin), HIV medications (such as ritonavir), rifamycins (such as rifabutin, rifampin), certain drugs used to treat seizures (such as carbamazepine, phenytoin), among others.

This medication may interfere with certain laboratory tests (including amylase/lipase levels), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.

Acetaminophen-Hydrocodone  may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Acetaminophen-Hydrocodone ?

Acetaminophen-Hydrocodone  may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

This drug may make you dizzy or drowsy. Alcohol or marijuana can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Avoid alcoholic beverages. Talk to your doctor if you are using marijuana.

What health conditions may interact with Acetaminophen-Hydrocodone ?

Acetaminophen-Hydrocodone  may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Liquid products may contain sugar and alcohol. Caution is advised if you have diabetes, alcohol dependence, liver disease, or any other condition that requires you to limit/avoid these substances in your diet. Ask your doctor or pharmacist about using this product safely.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this Acetaminophen-Hydrocodone .

What is the dose of Acetaminophen-Hydrocodone  for an adult?

Usual Adult Dose for Pain

Oral tablets:

Hydrocodone 5 mg-acetaminophen 325 mg per tablet

Initial dose: 1 to 2 tablets every 4 to 6 hours as needed for pain

Maximum dose: 8 tablets/24 hours

Hydrocodone 7.5 mg-acetaminophen 325 mg and Hydrocodone 10 mg-acetaminophen 325 mg per tablet:

Initial dose: 1 tablet every 4 to 6 hours as needed for pain

Maximum dose: 6 tablets/24 hours

Oral Solution:

Hydrocodone 7.5 mg-acetaminophen 325 mg per 15 mL:

Initial dose: 15 mL every 4 to 6 hours as needed for pain

Maximum dose: 90 mL/24 hours

Hydrocodone 10 mg-acetaminophen 300 mg per 15 mL:

Initial dose: 11.25 mL every 4 to 6 hours as needed for pain

Maximum dose: 67.5 mL/24 hours

Use: For the management of pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate.

Dose Adjustments

Acetaminophen-hydrocodone should be used with caution in elderly or debilitated patients and those with hypothyroidism, Addison’s disease, prostatic hypertrophy or urethral stricture; generally, start at the lower end of the dosing range and titrate carefully.

Maximum Acetaminophen Dose is 4 g in 24 hours

-Take into account all acetaminophen products when calculating daily dose.

-To avoid overdose of acetaminophen, it is best to use just 1 acetaminophen product at a time.

What is the dose of Acetaminophen-Hydrocodone  for a child?

Usual Pediatric Dose for Pain

2 years or older; weight less than 46 kg:

Weight-Based Dosing (preferred)

Initial dose: hydrocodone 0.135 mg/kg and acetaminophen 4 or 5.85 mg/kg orally every 4 to 6 hours as needed

-For hydrocodone 7.5 mg-acetaminophen 325 mg per 15 mL Oral Solution: 0.27 mL/kg orally every 4 to 6 hours

-For hydrocodone 10 mg-acetaminophen 300 mg per 15 mL Oral Solution: 0.2 mL/kg orally every 4 to 6 hours

Maximum: 6 doses in 24 hours

Age-Based Dosing:

-Hydrocodone 7.5 mg-acetaminophen 325 mg per 15 mL Oral Solution:

Approximately 2 to 3 years old (12 to 15 kg): Initial dose: 3.75 mL orally every 4 to 6 hours

Approximately 4 to 6 years old (16 to 22 kg): Initial dose: 5 mL orally every 4 to 6 hours

Approximately 7 to 9 years old (23 to 31 kg): Initial dose: 7.5 mL orally every 4 to 6 hours

Approximately 10 to 13 years old (32 to 45 kg): Initial dose: 10 mL orally every 4 to 6 hours

-Hydrocodone 10 mg-acetaminophen 300 mg per 15 mL Oral Elixir:

Approximately 2 to 3 years old (12 to 15 kg): Initial dose: 2.8 mL orally every 4 to 6 hours

Approximately 4 to 6 years old (16 to 22 kg): Initial dose: 3.75 mL orally every 4 to 6 hours

Approximately 7 to 9 years old (23 to 31 kg): Initial dose: 5.6 mL orally every 4 to 6 hours

Approximately 10 to 13 years old (32 to 45 kg): Initial dose: 7.5 mL orally every 4 to 6 hours

Maximum: 6 doses in 24 hours

2 years or older; weight 46 kg or greater:

Hydrocodone 7.5 mg-acetaminophen 325 mg per 15 mL:

Initial dose: 15 mL every 4 to 6 hours as needed for pain

Maximum dose: 6 doses/day not to exceed 90 mL/24 hours

Hydrocodone 10 mg-acetaminophen 300 mg per 15 mL:

Initial dose: 11.25 mL every 4 to 6 hours as needed for pain

Maximum dose: 6 doses/day not to exceed 67.5 mL/24 hours

Use: For the management of pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate.

Precautions

Safety and efficacy have not been established for oral liquid/solution in patients younger than 2 years.

Safety and efficacy have not been established for oral tablets in patients younger than 18 years

How is Acetaminophen-Hydrocodone  available?

Acetaminophen-Hydrocodone  is available in the following dosage forms and strengths:

  • Oral tablet,
  • Oral capsule,
  • Oral liquid,
  • Oral elixir,
  • Oral solution.

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Acetaminophen-Hydrocodone , take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

 

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: November 9, 2018 | Last Modified: November 9, 2018

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