Generic Name: Acetaminophen-Caffeine-Dihydrocodeine Brand Name(s): Generics only. No brands available. Avability: Rx Pregnancy Category: C

Uses

What is Acetaminophen-Caffeine-Dihydrocodeine used for?

Acetaminophen-Caffeine-Dihydrocodeine is a combination medication used to help relieve moderate to severe pain. It contains an opioid (narcotic) pain reliever (dihydrocodeine), a non-opioid pain reliever (acetaminophen), and caffeine. Dihydrocodeine works in the brain to change how your body feels and responds to pain. Acetaminophen can also reduce a fever. Caffeine increases pain relief, especially for certain types of headaches.

How should I take Acetaminophen-Caffeine-Dihydrocodeine?

Take this medication by mouth as directed by your doctor, usually every 4 hours as needed for pain. You may take this drug with or without food. If you have nausea, it may help to take this drug with food. Ask your doctor or pharmacist about other ways to decrease nausea (such as lying down for 1 to 2 hours with as little head movement as possible).

The dosage is based on your medical condition and response to treatment. Do not increase your dose or use this drug more often or for longer than prescribed because your risk of side effects may increase. Properly stop the medication when so directed.

Pain medications work best if they are used as the first signs of pain occur. If you wait until the pain has worsened, the medication may not work as well.

This medication may cause withdrawal reactions, especially if it has been used regularly for a long time or in high doses. In such cases, withdrawal symptoms (such as restlessness, irritability, trouble sleeping, sweating, anxiety, pounding heartbeat) may occur if you suddenly stop using this medication. To prevent withdrawal reactions, your doctor may reduce your dose gradually. Ask your doctor or pharmacist for more details, and report any withdrawal reactions right away.

When this medication is used for a long time, it may not work as well. Talk with your doctor if this medication stops working well.

Though it helps many people, this medication may sometimes cause addiction. This risk may be higher if you have a substance use disorder (such as overuse of or addiction to drugs/alcohol). Take this medication exactly as prescribed to lower the risk of addiction. Ask your doctor or pharmacist for more details.

Tell your doctor if your pain persists or worsens.

How do I store Acetaminophen-Caffeine-Dihydrocodeine?

Acetaminophen-Caffeine-Dihydrocodeine is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Acetaminophen-Caffeine-Dihydrocodeine in the bathroom or the freezer. There may be different brands of Acetaminophen-Caffeine-Dihydrocodeine that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Acetaminophen-Caffeine-Dihydrocodeine down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Acetaminophen-Caffeine-Dihydrocodeine?

Before taking this product, tell your doctor or pharmacist if you are allergic to dihydrocodeine, acetaminophen, or caffeine; or to other opioid pain medications (such as codeine, morphine); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: brain disorders (such as head injury, tumor, seizures), breathing problems (such as asthma, sleep apnea, chronic obstructive pulmonary disease-COPD), gallbladder disease, heart problems (such as irregular heartbeat, recent heart attack), kidney disease, liver disease, mental/mood disorders (such as confusion, depression, thoughts of suicide), personal or family history of a substance use disorder (such as overuse of or addiction to drugs/alcohol), obesity, stomach/intestinal problems (such as blockage, constipation, diarrhea due to infection, paralytic ileus), disease of the pancreas (pancreatitis), difficulty urinating (such as due to enlarged prostate).

Before having surgery or certain medical procedures (such as a heart stress test or a procedure to restore a normal heart rhythm if you have an unusually fast heartbeat), tell your doctor or dentist that you use this medication and about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Some children may be more sensitive to very serious side effects of the dihydrocodeine in this product, such as extreme sleepiness, confusion, or slow/shallow/noisy breathing.

Older adults may be more sensitive to the side effects of this drug, especially confusion, dizziness, drowsiness, trouble sleeping, and slow/shallow breathing.

During pregnancy, this medication should be used only when clearly needed. It may harm an unborn baby. Discuss the risks and benefits with your doctor.

This medication passes into breast milk and may have undesirable effects on a nursing infant, such as unusual sleepiness, difficulty feeding, trouble breathing, or unusual limpness. Breast-feeding while using this drug is not recommended. Consult your doctor before breast-feeding.

Is it safe during pregnancy or breast-feeding?

There are no adequate studies in women for determining risk when using this Acetaminophen-Caffeine-Dihydrocodeine during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Acetaminophen-Caffeine-Dihydrocodeine. Acetaminophen-Caffeine-Dihydrocodeine is pregnancy risk category C according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown

Side effects

What side effects can occur from Acetaminophen-Caffeine-Dihydrocodeine?

Nausea, vomiting, constipation, lightheadedness, dizziness, drowsiness, headache, increased urination, or trouble sleeping may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

To prevent constipation, eat dietary fiber, drink enough water, and exercise. Consult your pharmacist for help in selecting a laxative (such as a stimulant type with stool softener).

To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: mental/mood changes (such as irritability, nervousness, anxiety, hallucinations), fast/irregular heartbeat, stomach/abdominal pain, difficulty urinating, vision changes, shaking (tremor), signs of your adrenal glands not working well (such as loss of appetite, unusual tiredness, weight loss).

Get medical help right away if you have any very serious side effects, including: fainting, seizure.

Dihydrocodeine is changed into a strong opioid drug (dihydromorphine) in your body. In some people, this change happens faster and more completely than usual, which increases the risk of very serious side effects. Get medical help right away if you notice any of the following: slow/shallow breathing, severe drowsiness/difficulty waking up, confusion.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Acetaminophen-Caffeine-Dihydrocodeine?

Some products that may interact with this drug include: certain pain medications (mixed opioid agonist-antagonists such as pentazocine, nalbuphine, butorphanol), naltrexone.

The risk of serious side effects (such as slow/shallow breathing, severe drowsiness/dizziness) may be increased if this medication is taken with other products that may also cause drowsiness or breathing problems. Tell your doctor or pharmacist if you are taking other products such as other opioid pain or cough relievers (such as morphine, hydrocodone), alcohol, marijuana, drugs for sleep or anxiety (such as alprazolam, lorazepam, zolpidem), muscle relaxants (such as carisoprodol, cyclobenzaprine), or antihistamines (such as cetirizine, diphenhydramine).

Check the labels on all your medicines (such as allergy or cough-and-cold products, pain relievers) because they may also contain acetaminophen, caffeine, or ingredients that cause drowsiness. Ask your pharmacist about using those products safely.

Other medications can affect the removal of this product from your body, which may affect how this product works. Examples include azole antifungals (such as ketoconazole), bupropion, fluoxetine, macrolide antibiotics (such as erythromycin), HIV medications (such as ritonavir), paroxetine, quinidine, rifamycins (such as rifabutin, rifampin), certain drugs used to treat seizures (such as carbamazepine, phenytoin), among others.

This medication may interfere with certain medical/laboratory tests (including certain urine tests, amylase/lipase levels, dipyridamole-thallium imaging tests), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.

Acetaminophen-Caffeine-Dihydrocodeine may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Acetaminophen-Caffeine-Dihydrocodeine?

Acetaminophen-Caffeine-Dihydrocodeine may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

This drug may make you dizzy or drowsy. Alcohol or marijuana can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Avoid alcoholic beverages. Talk to your doctor if you are using marijuana. Avoid drinking large amounts of beverages containing caffeine (coffee, tea, colas) and eating large amounts of chocolate.

What health conditions may interact with Acetaminophen-Caffeine-Dihydrocodeine?

Acetaminophen-Caffeine-Dihydrocodeine may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this Acetaminophen-Caffeine-Dihydrocodeine.

What is the dose of Acetaminophen-Caffeine-Dihydrocodeine for an adult?

Usual Adult Dose for Pain

Initial dose: 2 capsules orally every 4 hours as needed

Maximum dose: 5 doses or 10 capsules in 24 hours; no more than 2 capsules should be taken within any 4-hour period.

Use: For the management of moderate to moderately severe pain that is severe enough to require an opioid analgesic and for which alternative treatments are inadequate.

Renal Dose Adjustments

Dose adjustment may be required; however, no specific guidelines have been suggested; consider a lower dose in patients with renal impairment

Liver Dose Adjustments

Use with caution; both acetaminophen and dihydrocodeine are metabolized by the liver; acetaminophen, especially at higher doses, may cause hepatotoxicity

Dose Adjustments

Use with caution in elderly patients.

Use with caution in patients with biliary tract disease including pancreatitis.

What is the dose of Acetaminophen-Caffeine-Dihydrocodeine for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Acetaminophen-Caffeine-Dihydrocodeine available?

Acetaminophen-Caffeine-Dihydrocodeine is available in the following dosage forms and strengths:

  • Oral capsule,
  • Oral tablet.

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Acetaminophen-Caffeine-Dihydrocodeine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

 

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: November 6, 2018 | Last Modified: November 6, 2018

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