Generic Name: Acalabrutinib Brand Name(s): Generics only. No brands available. Avability: Rx Pregnancy Category: N

Uses

What is Acalabrutinib used for?

Acalabrutinib is used to treat a certain type of cancer (mantle cell lymphoma-MCL) after previous treatment(s) have not worked well. Acalabrutinib works by slowing or stopping the growth of cancer cells. It belongs to a class of drugs known as kinase inhibitors.

How should I take Acalabrutinib?

Take this medication by mouth with or without food as directed by your doctor, usually two times a day (about 12 hours apart). Swallow the capsule whole with a glass of water. Do not open, break, or chew the capsules.

Medications that decrease stomach acid may make acalabrutinib work less well. If you need to take an antacid, take it either 2 hours before or 2 hours after you take this medication. If you are taking an H2 blocker (such as ranitidine, famotidine), take acalabrutinib at least 2 hours before these medications. Avoid taking proton pump inhibitors (such as omeprazole, pantoprazole). Ask your doctor or pharmacist for more details.

The dosage is based on your medical condition, response to treatment, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Do not increase your dose or use this drug more often or for longer than prescribed. Your condition will not improve any faster, and your risk of serious side effects will increase.

Take this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day.

Since this drug can be absorbed through the skin and lungs and may harm an unborn baby, women who are pregnant or who may become pregnant should not handle this medication or breathe the dust from the tablets.

How do I store Acalabrutinib?

Acalabrutinib is best stored at 20 to 25 degrees Celsius; excursions permitted to 15 to 30 degrees Celsius. To prevent drug damage, you should not store Acalabrutinib in the bathroom or the freezer. There may be different brands of Acalabrutinib that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Acalabrutinib down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Acalabrutinib?

Before taking acalabrutinib, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: bleeding/blood problems (such as ulcers), fast/irregular heartbeat, recent/current infection (including hepatitis, HIV infection).

This medication may increase your risk for other cancers, including skin cancer. Limit your time in the sun. Avoid tanning booths and sunlamps. Use sunscreen and wear protective clothing when outdoors.

Acalabrutinib can make you more likely to get infections or may worsen any current infections. Avoid contact with people who have infections that may spread to others (such as chickenpox, measles, flu). Consult your doctor if you have been exposed to an infection or for more details.

Do not have immunizations/vaccinations without the consent of your doctor. Avoid contact with people who have recently received live vaccines (such as flu vaccine inhaled through the nose).

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Since this drug can be absorbed through the skin and lungs and may harm an unborn baby, women who are pregnant or who may become pregnant should not handle this medication or breathe the dust from the tablets.

Tell your doctor if you are pregnant or plan to become pregnant. You should not become pregnant while using acalabrutinib. Acalabrutinib may harm an unborn baby. If you become pregnant, talk to your doctor right away about the risks and benefits of this medication.

It is unknown if this drug passes into breast milk. Because of the possible risk to the infant, breast-feeding while using this drug and for at least 2 weeks after stopping treatment is not recommended. Consult your doctor before breast-feeding.

Is it safe during pregnancy or breast-feeding?

There are no adequate studies in women for determining risk when using this Acalabrutinib during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Acalabrutinib. Acalabrutinib is pregnancy risk category N according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown

Side effects

What side effects can occur from Acalabrutinib?

Headache, nausea, vomiting, abdominal pain, diarrhea, tiredness, or muscle aches may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

Tell your doctor right away if you have any serious side effects, including: unusual tiredness, easy or unusual bruising or bleeding (such as nose/gum bleeds, pink/dark urine, black/bloody stools, vomit that contains blood or looks like coffee grounds), signs of heart problems (such as fast/irregular heartbeat, dizziness, fainting, shortness of breath, chest discomfort).

This medication may lower your ability to fight infections. This may make you more likely to get a serious (rarely fatal) infection or make any infection you have worse. Tell your doctor right away if you have any signs of infection (such as sore throat that doesn’t go away, fever, chills, cough).

Although acalabrutinib is used to treat cancer, it may rarely increase your risk of developing other cancers (such as skin cancer). Tell your doctor right away if you develop unusual growths or lumps, swollen glands, sudden weight loss, night sweats, change in appearance or size of moles, or unusual skin changes/growth.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Acalabrutinib?

Other medications can affect the removal of acalabrutinib from your body, which may affect how acalabrutinib works. Examples include azole antifungals (such as ketoconazole, itraconazole, voriconazole), macrolide antibiotics (such as clarithromycin, erythromycin), HIV protease inhibitors (such as ritonavir, atazanavir, nelfinavir, saquinavir, indinavir), rifamycins (such as rifampin, rifabutin), drugs to treat seizures (such as phenytoin, carbamazepine, phenobarbital), nefazodone, St. John’s wort, telithromycin, among others.

Acalabrutinib may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with Acalabrutinib?

Acalabrutinib may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

Avoid eating grapefruit or drinking grapefruit juice while using this medication unless your doctor or pharmacist says you may do so safely. Grapefruit can increase the chance of side effects with this medicine.

This drug may make you dizzy. Alcohol or marijuana can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana.

What health conditions may interact with Acalabrutinib?

Acalabrutinib may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this Acalabrutinib.

What is the dose of Acalabrutinib for an adult?

Usual Adult Dose for Lymphoma

100 mg orally approximately every 12 hours

Duration of Therapy: Until disease progression or unacceptable toxicity

Use: Treatment of adult patients with mantle cell lymphoma (MCL) who have received at least one prior therapy.

What is the dose of Acalabrutinib for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Acalabrutinib available?

Acalabrutinib is available in the following dosage forms and strengths:

  • Oral capsule.

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of Acalabrutinib, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

 

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: November 5, 2018 | Last Modified: November 5, 2018

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