Generic Name: Abiraterone acetate Brand Name(s): Generics only. No brands available.

Uses

What is abiraterone acetate used for?

Abiraterone acetate is commonly used for treating a certain type of prostate cancer that has spread to other parts of the body. It is used along with another medicine (prednisone). It may also be used for other conditions as determined by your doctor.

How should I take abiraterone acetate?

Use abiraterone acetate as directed by your doctor. Check the label on the medicine for exact dosing instructions.

An extra patient leaflet is available with abiraterone acetate. Talk to your pharmacist if you have questions about this information.

Take abiraterone acetate by mouth on an empty stomach at least 1 hour before or 2 hours after eating. Do not take it with food. The amount of abiraterone acetate in your body may be increased if you take it with food. This may increase the risk of side effects.

Swallow abiraterone acetate whole with water. Do not break, crush, or chew before swallowing.

How do I store abiraterone acetate?

Abiraterone acetate is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store abiraterone acetate in the bathroom or the freezer. There may be different brands of abiraterone acetate that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush abiraterone acetate down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using abiraterone acetate?

Before using abiraterone acetate, tell your doctor if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with any of active or inactive ingredients of abiraterone acetate or other medications.
  • You have any other illnesses, disorders, or medical conditions.
  • You have a history of liver problems, heart problems (e.g., heart failure, irregular heartbeat), a recent heart attack, or high blood pressure.
  • You have low blood potassium levels or a history of adrenal gland problems, pituitary gland problems, or fluid retention or swelling (edema).

Do not change your dose or stop taking abiraterone acetate or prednisone without checking with your doctor.

Abiraterone acetate is taken along with prednisone. Use caution if your doctor tells you to stop taking prednisone or to reduce the dose, or if you experience events that cause physical stress. Such events may include injury, surgery, infection, loss of blood electrolytes, or a sudden asthma attack. Contact your doctor right away if any of these events occur. You may need to increase your dose of prednisone before, during, and after stressful situations as directed by your doctor. Discuss any questions or concerns with your doctor.

An increased occurrence of bone fractures has been reported in patients using abiraterone acetate. Contact your doctor right away if you experience bone pain. Discuss any questions or concerns with your doctor.

Abiraterone acetate may cause harm to a developing fetus. Women who are pregnant or may become pregnant should not handle abiraterone acetate without protection (e.g., gloves). If contact occurs, tell your doctor at once.

Men who take abiraterone acetate should always use a condom when having sex with a woman who is pregnant. A condom and another form of effective birth control should be used when having sex with a woman who may become pregnant. Use these methods for as long as you take abiraterone acetate and for 1 week after you stop taking it.

Tell your doctor or dentist that you take abiraterone acetate before you receive any medical or dental care, emergency care, or surgery.

Lab tests, including liver function, blood pressure, and blood potassium levels, may be performed while you use abiraterone acetate. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using this medication during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking this medication. This medication is pregnancy risk category X, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from abiraterone acetate?

Common side effects are listed below:

  • Cough
  • Diarrhea
  • Heartburn
  • Hot flushes
  • Joint swelling or pain
  • Mild muscle discomfort
  • Tiredness
  • Vomiting
  • Weakness

Seek medical attention right away if any of these severe side effects occur:

  • Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue)
  • Bone pain
  • Chest pain or discomfort
  • Confusion
  • Fainting
  • Fast, slow, or irregular heartbeat
  • Fever, chills, or persistent sore throat
  • Leg pain
  • Muscle pain, weakness, or cramping
  • Severe or persistent headache, dizziness, or light-headedness
  • Shortness of breath
  • Sudden or unexplained weight gain
  • Swelling of the hands, ankles, legs, or feet
  • Symptoms of liver problems (e.g., dark urine; loss of appetite; pale stools; unusual nausea, stomach pain, or tiredness; yellowing of the skin or eyes)
  • Unusual bruising
  • Unusual tiredness or weakness
  • Urination problems (e.g., difficult, increased, or painful urination)

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with abiraterone acetate?

Abiraterone acetate may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Products that may interact with this drug are:

  • Atazanavir, clarithromycin, indinavir, itraconazole, ketoconazole, nefazodone, nelfinavir, ritonavir, saquinavir, telithromycin, or voriconazole
  • Carbamazepine, phenobarbital, phenytoin, rifabutin, rifampin, or rifapentine
  • Carvedilol, chlorpromazine, desipramine, dextromethorphan, encainide, flecainide, iloperidone, maprotiline, metoprolol, nortriptyline, paroxetine, pimozide, propafenone, propranolol, risperidone, tetrabenazine, or thioridazine

Does food or alcohol interact with abiraterone acetate?

Abiraterone acetate may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with abiraterone acetate?

Abiraterone acetate may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Health conditions that may interact with this drug are:

  • Low blood potassium levels or a history of adrenal gland problems
  • Pituitary gland problems
  • Fluid retention or swelling (edema)
  • History of liver problems
  • Heart problems (e.g., heart failure, irregular heartbeat)
  • A recent heart attack
  • High blood pressure

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using abiraterone acetate.

What is the dose of abiraterone acetate for an adult?

Recommended doses for prostate cancer is 4 tablets (1000 mg) per day combined with prednisone 5 mg each 12 hours.

What is the dose of abiraterone acetate for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is abiraterone acetate available?

Abiraterone acetate is available in the following dosage forms and strengths:

  • Tablet 250 mg

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of abiraterone acetate, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: July 23, 2017 | Last Modified: July 23, 2017

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