Abelcet

By Medically reviewed by hellodoktor

Generic Name: Abelcet Brand Name(s): Generics only. No brands available.

Uses

What is Abelcet® (amphotericin b lipid complex) used for?

Abelcet® is an antifungal antibiotic. It works by killing the fungus and preventing its reproduction.

Abelcet® is commonly used for treating invasive fungal infections in patients who cannot tolerate other forms of Abelcet®.

It may be prescribed for other uses; ask your doctor or pharmacist for more information.

How should I take Abelcet® (amphotericin b lipid complex)?

Abelcet® is given as an injection at your doctor’s office, hospital, or clinic. Contact your health care provider if you have any questions.

How do I store Abelcet® (amphotericin b lipid complex)?

Abelcet® is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store Abelcet® in the bathroom or the freezer. There may be different brands of Abelcet® that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Abelcet® down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Abelcet® (amphotericin b lipid complex)?

Consult with your doctor or pharmacist, if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with any of active or inactive ingredients of Abelcet® or other medications.
  • You have any other illnesses, disorders, or medical conditions.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using Abelcet® during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Abelcet®. Abelcet® is pregnancy risk category B, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from Abelcet® (amphotericin b lipid complex)?

These following side effects may occur 1 to 2 hours after the infusion is started, such as:

  • Fever
  • Shaking
  • Chills
  • Flushing
  • Loss of appetite
  • Dizziness
  • Nausea
  • Vomiting
  • Headache
  • Shortness of breath
  • Fast breathing

Tell your doctor right away if you have any serious side effects, including:

  • Swelling/pain at injection site
  • Muscle/joint pain
  • Unusual tiredness
  • Weakness
  • Muscle cramping
  • Signs of kidney problems, such as change in the amount of urine, painful urination
  • Numbness/tingling of arms/legs
  • Vision changes
  • Hearing changes (e.g., ringing in the ears)
  • Dark urine
  • Severe stomach/abdominal pain
  • Yellowing eyes/skin
  • Swelling ankles/feet
  • Fast/slow/irregular heartbeat
  • Cold sweats
  • Blue lips
  • Easy bruising/bleeding
  • Other signs of infection (e.g., fever, persistent sore throat)
  • Mental/mood changes
  • Seizures
  • Black stools
  • Vomit that looks like coffee grounds
  • Allergic reaction, including rash, severe dizziness, trouble breathing

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with Abelcet® (amphotericin b lipid complex)?

Abelcet® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Some products that may interact with this drug include:

  • Antineoplastic agents: Taking antineoplastic agents and amphotericin B may increase the potential for renal toxicity, bronchospasm, and hypotension.
  • Corticosteroids and corticotropin (ACTH): Taking corticosteroids and corticotropin (ACTH) with amphotericin B may potentiate hypokalemia which could predispose the patient to cardiac dysfunction.
  • Digitalis glycosides: Taking Abelcet® may induce hypokalemia and may potentiate digitalis toxicity.
  • Flucytosine: Taking flucytosine with Abelcet® may increase the toxicity of flucytosine by possibly increasing its cellular uptake and/or impairing its renal excretion.
  • Imidazoles (e.g., ketoconazole, miconazole, clotrimazole, fluconazole, etc.): Antagonism between Abelcet® and imidazole derivatives such as miconazole and ketoconazole, which inhibit ergosterol synthesis, has been reported in both in vitro and in vivo animal studies.
  • Leukocyte transfusions: Acute pulmonary toxicity has been reported in patients receiving intravenous Abelcet® and leukocyte transfusions.
  • Other nephrotoxic medications: Taking Abelcet® and agents such as aminoglycosides and pentamidine may enhance the potential for drug-induced renal toxicity.
  • Skeletal Muscle Relaxants: Abelcet® induced hypokalemia may enhance the curariform effect of skeletal muscle relaxants (e.g., tubocurarine) due to hypokalemia.
  • Other medications: Zidovudine, Cyclosporin A

Does food or alcohol interact with Abelcet® (amphotericin b lipid complex)?

Abelcet® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Abelcet® (amphotericin b lipid complex)?

Abelcet® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this medication.

What is the dose of Abelcet® (amphotericin b lipid complex) for an adult?

Systemic Fungal Infection:

The recommended dose is 5 mg/kg IV (intravenous route) everyday; infuse IV at rate of 2.5 mg/hour.

Renal Impairment

The recommended dose is CrCl <10 mL/min: 5 mg/kg IV every 24-36 hours.

What is the dose of Abelcet® (amphotericin b lipid complex) for a child?

Systemic Fungal Infection:

The recommended dose is 5 mg/kg IV qDay; infuse IV at rate of 2.5 mg/hour.

Renal Impairment

The recommended dose is CrCl <10 mL/min: 5 mg/kg IV every 24-36 hours.

How is Abelcet® (amphotericin b lipid complex) available?

Abelcet® is available in the following dosage forms and strengths:

  • 100 mg of Abelcet® in 20 mL of suspension

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of medication, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Review Date: May 25, 2017 | Last Modified: September 12, 2019

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