Generic Name: Abbokinase Brand Name(s): Generics only. No brands available.

Uses

What is abbokinase (urokinase) used for?

Abbokinase is a product using protein, which occurs naturally in the kidneys. This thrombolytic agent is commonly used for the treatment blood clots in the lungs.

Abbokinase may also be used for purposes; ask your doctor for more information.

How should I take abbokinase (urokinase)?

Abbokinase is given as an injection through a needle placed into a vein. You will receive this injection in a clinic or hospital setting. It is given slowly, usually over a period of 12 hours, using a continuous infusion pump.

Your doctor will closely check your breathing, blood pressure, oxygen levels, and other vital signs while you are receiving urokinase.

How do I store abbokinase (urokinase)?

Abbokinase is best stored in the refrigerator. To prevent drug damage, do not freeze. There may be different brands of abbokinase that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush abbokinase down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using abbokinase (urokinase)?

Before using this drug, tell your doctor if you have:

  • Allergic to any ingredients of abbokinase
  • Internal bleeding
  • A brain tumor
  • A brain aneurysm (dilated blood vessel)
  • A bleeding or blood clotting disorder (such as hemophilia)
  • An arterial hypertension
  • A recent medical emergency requiring CPR (cardiopulmonary resuscitation)
  • A stroke, brain surgery, or spinal surgery within in the past 2 months

Also, avoid taking aspirin or ibuprofen (Motrin, Advil) to treat a fever shortly after you have received urokinase. These medications can increase your risk of bleeding.

Avoid activities that may increase your risk of bleeding or injury. Use extra care to prevent bleeding while shaving or brushing your teeth.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using abbokinase during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking abbokinase. Abbokinase is pregnancy risk category B, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Breastfeeding

It is not known whether abbokinase passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breastfeeding a baby.

Side effects

What side effects can occur from abbokinase (urokinase)?

When using this drug, you may have some side effects, get emergency medical help if you have these signs of allergic reaction:

  • Hives
  • Difficult breathing
  • Swelling of your face, lips, tongue, or throat

Besides, urokinase increases your risk of bleeding, which can be severe or life-threatening. Call your doctor immediately if you have bleeding, which does not stop. Bleeding may occur from a surgical incision, or from the skin where a needle was inserted during a blood test or while receiving injectable medication. You may also have bleeding on the inside of your body, such as in your stomach or intestines, kidneys or bladder, brain, or within the muscles.

Call your doctor if you notice these signs of bleeding inside your body, such as:

  • Easy bruising or bleeding (nosebleeds, bleeding gums, bleeding from a wound, incision, catheter, or needle injection)
  • Bloody or tarry stools
  • Coughing up blood or vomit
  • Red or pink urine
  • Sudden numbness or weakness (especially on one side of the body)
  • Sudden severe headache
  • Slurred speech
  • Problems with vision or balance

Also call your doctor at once if you have:

  • Chest pain or heavy feeling
  • Pain spreading to the jaw or shoulder
  • Nausea
  • Sweating
  • General ill feeling
  • Fever
  • Chills
  • Flu symptoms
  • Vomiting
  • Stomach pain
  • Swelling
  • Rapid weight gain
  • Little or no urinating
  • Red or purple discoloration of fingers or toes
  • Weak or shallow breathing
  • Blue-colored lips or fingernails
  • Dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure)
  • Pancreatitis (severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate)

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.

Interactions

What drugs may interact with abbokinase (urokinase)?

Abbokinase may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Products that may interact with this drug include:

  • NSAIDs (nonsteroidal anti-inflammatory drugs): aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others
  • Medication used to prevent blood clots such as dabigatran, dalteparin, desirudin, enoxaparin, fondaparinux, tinzaparin, warfarin, Coumadin

Does food or alcohol interact with abbokinase (urokinase)?

Abbokinase may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with abbokinase (urokinase)?

Abbokinase may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

To make sure urokinase is safe for you, tell your doctor if you have:

  • A history of stroke
  • Severe liver or kidney disease
  • Eye problems caused by diabetes
  • An infection of the lining of your heart (also called bacterial endocarditis)
  • A blood clot of your heart
  • A recent history of stomach or intestinal bleeding
  • A surgery or an organ transplant within the past 10 days

Dosage

The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using abbokinase (urokinase).

What is the dose of abbokinase (urokinase) for an adult?

Myocardial infarction:

Lysis of coronary artery thrombi:

Prior to beginning urokinase, a bolus of heparin 2500 to 10,000 units IV once should be given. Prior heparin administration should be considered when calculating the heparin dose.

Systemic thrombolytic administration:

1 to 2 million units administered IV once over 15 to 30 minutes. The rate of infusion is limited by side effects (fever, chills, rigors), and may need to be decreased in some patients. Doses up to 3 million units have been used to treat acute myocardial infarction (AMI).

To determine the response to urokinase, the manufacturer recommends serial angiography every 15 minutes. Maximal coronary artery opening usually occurs 15 to 30 minutes after opening begins.

Pulmonary embolism:

The initial dose is 4400 units/kg ideal body weight (IBW) administered as an IV bolus over 10 minutes.

The maintenance dose is 4400 units/kg (IBW) /hour administered as a continuous IV infusion for 12 hours.

Deep vein thrombosis:

The initial dose is 4400 units/kg ideal body weight (IBW) administered as an IV bolus over 10 minutes.

The maintenance dose is 4400 units/kg (IBW) /hour administered as a continuous IV infusion for 72 hours. Treatment may be needed for as long as 10 to 14 days in selected patients.

Thrombotic/Thromboembolic disorder:

IV catheter clearance:

When the following procedure is used for thrombolysis of a central venous catheter, the patient should be asked to hold his/her breath at end-exhalation any time the catheter is not connected to IV tubing, a heparin lock, or a syringe (to avoid air embolism).

Once a clot is suspected (after gentle aspiration of the affected catheter with a 10 ml syringe), 5000 units urokinase in a 1 ml tuberculin syringe may be slowly and gently injected, using only an amount equivalent to the volume of the catheter. A 5 or 10 ml syringe may be used to gently aspirate from the catheter every 5 minutes. If the catheter is not open within 30 minutes, the catheter may be capped allowing urokinase to dwell inside for 30 to 60 minutes before again attempting to aspirate. A second injection may be necessary in resistant cases.

Once patency is restored, aspiration and removal of 5 ml of blood is recommended to remove all drug and clot residual. Flushing the catheter with normal saline injection is then recommended.

What is the dose of abbokinase (urokinase) for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is abbokinase (urokinase) available?

Abbokinase is available in the following dosage forms and strengths:

  • For injection, IV infusion 250000 units

What should I do in case of an emergency or overdose?

Since this medication is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I do if I miss a dose?

Because you will receive urokinase in a clinical setting, you are not likely to miss a dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: March 28, 2017 | Last Modified: March 28, 2017

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