By Medically reviewed by hellodoktor

Generic Name: A-methapred Brand Name(s): A-methapred and A-methapred.


What is A-methapred® used for?

Methylprednisolone is a steroid preventing inflammatory in many health conditions, such as arthritis, lupus, psoriasis, ulcerative colitis, allergic disorders, gland (endocrine) disorders.

How should I take A-methapred®?

A-methapred® is injected by the healthcare provider in the hospital. You should follow directions of your doctor and information on your prescription label. Consult your doctor if there are things that you do not clearly understand.

You should not stop using methylprednisolone suddenly, or you could have unpleasant withdrawal symptoms. Follow your doctor’s instructions about tapering your dose.

How do I store A-methapred®?

A-methapred® is best stored at room temperature away from direct light and moisture. To prevent drug damage, you should not store A-methapred® in the bathroom or the freezer. There may be different brands of A-methapred® that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush A-methapred® down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using A-methapred®?

Before taking methylprednisolone, tell your doctor if you have any of followings:

  • History of allergic reaction of methylprednisolone
  • Fungal infection
  • Heart disease
  • High blood pressure
  • Kidney disease
  • Cirrhosis or other liver diseases
  • Past or present tuberculosis
  • Glaucoma or cataracts
  • Herpes infection of the eyes
  • Seizures
  • Epilepsy
  • Recent head injury
  • Stomach ulcers
  • Ulcerative colitis
  • Diverticulitis
  • Recent intestinal surgery
  • Diarrhea caused by parasite infection
  • A thyroid disorder
  • Osteoporosis
  • Low bone mineral density
  • Depression or mental illness
  • A muscle disorder such as myasthenia gravis
  • An electrolyte imbalance
  • High levels of calcium in the blood related to cancer
  • Taken insulin or oral diabetes; or aspirin on a daily basis or at high doses
  • Been in pregnancy or breastfeeding period, or plan to become pregnant

Before taking this medicine for your children, ask your doctor to make sure it is safe.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using A-methapred® during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking A-methapred®. A-methapred® is pregnancy risk category C and category D for women in the first trimester, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk
  • B=No risk in some studies
  • C=There may be some risk
  • D=Positive evidence of risk
  • X=Contraindicated
  • N=Unknown

Side effects

What side effects can occur from A-methapred®?

Using A-methapred® can cause some side effects, such as:

  • Headache
  • Mild muscle pain
  • Weakness
  • Stomach discomfort
  • Bloating
  • Blurred vision
  • Tunnel vision
  • Eye pain
  • Seeing halos around lights
  • Shortness of breath (even with mild exertion)
  • Swelling
  • Rapid weight gain
  • Severe depression
  • Changes in personality
  • Unusual thoughts or behavior
  • New or unusual pain in an arm or leg or in your back
  • Bloody or tarry stools
  • Coughing up blood or vomit that looks like coffee grounds
  • A seizure (convulsions)
  • Low potassium-leg cramps
  • Constipation
  • Irregular heartbeats
  • Fluttering in your chest
  • Increased thirst or urination
  • Numbness or tingling
  • Muscle weakness or limp feeling

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.


What drugs may interact with A-methapred®?

A-methapred® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs of followings without your doctor’s approval

Products may interact with this drug, including:

Rotavirus Vaccine, Live



















































Does food or alcohol interact with A-methapred®?

A-methapred® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with A-methapred®?

A-methapred® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have, especially:

  • Brain injury, traumatic
  • Cerebral malaria
  • Fungal infections, systemic
  • Herpes simplex eye infection, active
  • Idiopathic thrombocytopenic purpura (low platelet count)
  • Cataracts
  • Cirrhosis (liver problem)
  • Congestive heart failure
  • Cushing’s syndrome (adrenal gland problem)
  • Depression
  • Diabetes
  • Emotional problems
  • Eye infection
  • Glaucoma
  • Heart attack
  • Heart disease
  • Hyperglycemia (high blood sugar)
  • Hypertension (high blood pressure)
  • Mental illness
  • Myasthenia gravis (severe muscle weakness)
  • Osteoporosis (weak bones)
  • Stomach or bowel problems (e.g., diverticulitis, ulcers, ulcerative colitis)
  • Thyroid problems
  • Tuberculosis, inactive
  • Infection (bacteria, virus, fungus, parasite, or protozoa)


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using A-methapred®.

What is the dose of A-methapred® for an adult?

The dosage of A-methapred® injected should be calculated by your doctor, depending on the health conditions for which you have to use A-methapred® to treat. You must follow directly as the prescription of your doctor.

What is the dose of A-methapred® for a child?

The dosage of A-methapred® injected should be calculated by your doctor, depending on the health conditions for which you have to use A-methapred® to treat.

The range of initial doses is 0.11 to 1.6 mg/kg/day in three or four divided doses (3.2 to 48 mg/m2bsa/day).

A-methapred® is contradicted in the premature child.

How is A-methapred® available?

A-methapred® is available in the following dosage forms and strengths:

  • Solution: 125mg/2 ml; 40 mg/ml

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of A-methapred®, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

msBahasa Malaysia


Review Date: September 21, 2016 | Last Modified: September 13, 2019

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