A-Hydrocort Injection

By Medically reviewed by hellodoktor

Generic Name: A-Hydrocort Injection Brand Name(s): Generics only. No brands available. Avability: Rx Pregnancy Category: C


What is A-Hydrocort Injection used for?

A-Hydrocort injection is the brand name of Hydrocortisone Sodium Succinate. This medication is used to treat various conditions such as arthritis, severe allergies, blood diseases, breathing problems, certain cancers, eye diseases, intestinal disorders, and skin diseases. It weakens your immune system’s response to various diseases to reduce symptoms such as swelling and allergic-type reactions. Hydrocortisone may also be used with other medications to replace certain hormones if you have decreased adrenal gland function or Addison’s disease. Hydrocortisone belongs to a class of drugs known as corticosteroids.

Hydrocortisone injection is used when a similar drug cannot be taken by mouth or when a very fast treatment is needed for patients with severe medical conditions. Talk to your doctor about the risks and benefits of hydrocortisone, especially if it is to be injected near your spine (epidural). Rare but serious side effects may occur with epidural use.

How should I take A-Hydrocort Injection?

This medication is given by slow injection into a vein or directly into a muscle, as directed by your doctor. The dosage is based on your medical condition and response to treatment.

If you are using this medication at home, learn all preparation and usage instructions from your health care professional. Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid. Learn how to store and discard medical supplies safely.

Do not stop using this medication without consulting your doctor. Some conditions may become worse when this drug is suddenly stopped.

How do I store A-Hydrocort Injection?

Hydrocort Injectionis best stored at 20 to 25°Caway from direct light and moisture. Use solution only if it is clear. Unused solution should be discarded after 3 days.

To prevent drug damage, you should not store A-Hydrocort Injection in the bathroom or the freezer. There may be different brands of A-Hydrocort Injection that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush A-Hydrocort Injection down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using A-Hydrocort Injection?

Before using hydrocortisone, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: bleeding problems, blood clots, bone loss (osteoporosis), diabetes, certain eye diseases (such as cataracts, glaucoma, herpes infection of the eye), heart problems (such as heart failure, recent heart attack), high blood pressure, current/past infections (such as those caused by fungus, herpes, tuberculosis, threadworm), kidney disease, liver disease, mental/mood conditions (such as psychosis, anxiety, depression), stomach/intestinal problems (such as diverticulitis, ulcer, ulcerative colitis), seizures, thyroid problems, mineral imbalance (such as low levels of potassium or calcium in the blood).

This drug may make you dizzy. Alcohol or marijuana can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Talk to your doctor if you are using marijuana.

Using corticosteroid medications for a long time can make it more difficult for your body to respond to physical stress. Before having surgery or emergency treatment, or if you get a serious illness/injury, tell your doctor or dentist that you are using this medication or have used this medication within the past 12 months. Tell your doctor right away if you develop unusual/extreme tiredness or weight loss. If you will be using this medication for a long time, carry a warning card or medical ID bracelet that identifies your use of this medication.

This medication may mask signs of infection. It can make you more likely to get infections or may worsen any current infections. Avoid contact with people who have infections that may spread to others (such as chickenpox, measles, flu). Consult your doctor if you have been exposed to an infection or for more details.

Do not have immunizations, vaccinations, or skin tests without the consent of your doctor. Avoid contact with people who have recently received live vaccines (such as flu vaccine inhaled through the nose).

Older adults may be more sensitive to the side effects of this drug, especially osteoporosis.

This medication may slow down a child’s growth if used for a long time. Consult the doctor or pharmacist for more details. See the doctor regularly so your child’s height and growth can be checked.

During pregnancy, this medication should be used only when clearly needed. It may rarely harm an unborn baby. Discuss the risks and benefits with your doctor. Infants born to mothers who use this medication for a long time may have hormone problems. Tell your doctor right away if you notice symptoms such as nausea/vomiting that doesn’t stop, severe diarrhea, or weakness in your newborn.

This medication passes into breast milk but is unlikely to harm a nursing infant. Consult your doctor before breast-feeding.

Is it safe during pregnancy or breast-feeding?

There are no adequate studies in women for determining risk when using this A-Hydrocort Injection during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking A-Hydrocort Injection. A-Hydrocort Injection is pregnancy risk category C according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk,
  • B=No risk in some studies,
  • C=There may be some risk,
  • D=Positive evidence of risk,
  • X=Contraindicated,
  • N=Unknown

Side effects

What side effects can occur from A-Hydrocort Injection?

Stomach upset, headache, dizziness, trouble sleeping, appetite changes, menstrual period changes, acne, or pain/redness/swelling at the injection site may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

This medication may raise your blood pressure. Check your blood pressure regularly and tell your doctor if the results are high.

This medication may make your blood sugar rise, which can cause or worsen diabetes. Tell your doctor right away if you have symptoms of high blood sugar such as increased thirst/urination. If you already have diabetes, check your blood sugar regularly as directed and share the results with your doctor. Your doctor may need to adjust your diabetes medication, exercise program, or diet.

This medication may lower your ability to fight infections. This may make you more likely to get a serious (rarely fatal) infection or make any infection you have worse. Tell your doctor right away if you have any signs of infection (such as sore throat that doesn’t go away, fever, chills, cough).

Tell your doctor right away if you have any serious side effects, such as: weakness, puffy face, muscle pain/cramps, unusual weight gain, slow wound healing, thinning skin, bone/joint pain, mental/mood changes (such as depression, mood swings, agitation), easy bruising/bleeding, vision problems, swelling ankles/feet/hands, fast/slow/irregular heartbeat, unusual hair/skin growth.

Get medical help right away if you have any very serious side effects, such as: severe stomach/abdominal pain, black/bloody stools, vomit that looks like coffee grounds, seizures.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, such as: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side-effect, please consult your doctor or pharmacist.


What drugs may interact with A-Hydrocort Injection?

Some products that may interact with this drug are: aldesleukin, mifepristone, other drugs that can cause bleeding/bruising (such as antiplatelet drugs like clopidogrel, NSAIDs like ibuprofen/naproxen, “blood thinners” like warfarin/dabigatran).

Aspirin can increase the risk of bleeding when used with this medication. However, if your doctor has directed you to take low-dose aspirin for heart attack or stroke prevention (usually at dosages of 81-325 milligrams a day), you should continue taking it unless your doctor instructs you otherwise. Ask your doctor or pharmacist for more details.

This medication may interfere with certain lab tests (such as skin tests), possibly causing false test results. Make sure lab personnel and all your doctors know you use this drug.

A-Hydrocort Injection may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Does food or alcohol interact with A-Hydrocort Injection?

Hydrocort Injectionmay interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor orpharmacist any potential food or alcohol interactions before using this drug.

This medicine may cause stomach bleeding. Daily use of alcohol while using this medicine may increase your risk for stomach bleeding. Limit alcoholic beverages.

What health conditions may interact with A-Hydrocort Injection?

A-Hydrocort Injection may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this A-Hydrocort Injection.

What is the dose of A-Hydrocort Injection for an adult?

Usual Adult Dose for Inflammation

15-240 mg every 12 hours

Usual Adult Dose for Status Asthmaticus

1-2 mg/kg intravenously (IV) every 6 hours initially for 24 hours; maintenance: 0.5-1 mg/kg every 6 hours

Usual Adult Dose for Acute Adrenal Insufficiency

100 mg intravenous (IV) bolus, then 300 mg/day IV divided every 8 hours or administered by continuous infusion for 48 hours

When patient is stabilized: 50 mg orally every 8 hours for 6 doses, then tapered to 30-50 mg/day orally in divided doses

Dosage Considerations

Usual oral dosing range: 10-320 mg/day divided every 6-8 hours

Usual intravenous/intramuscular (IV/IM) dosing range (sodium succinate): 100-500 mg as needed initially; may be repeated every 2 hours, every 4 hours, or every 6 hours as needed

What is the dose of A-Hydrocort Injection for a child?

Usual Pediatric Dose for Inflammation

Children under 12 years: 1-5 mg/kg/day IM/IV divided every 12-24 hours

Children 12 years and older: 15-240 mg every 12 hours

Usual Pediatric Dose for Status Asthmaticus

1-2 mg/kg IV every 6 hours for 24 hours; not to exceed 250 mg

IV Maintenance: 2 mg/kg/day IV divided every 6 hours

Usual Pediatric Dose for Physiologic Replacement

8-10 mg/m²/day divided every 8 hours

Usual Pediatric Dose for Acute Adrenal Crisis (Off-label)

Children age 1 month-1 year

25 mg intravenous (IV) bolus, then 50 mg/m²/day by continuous IV drip or divided every 6-8 hours

Alternative: 1-2 mg/kg IV bolus, then 25-150 mg/kg/day IV divided every 6-8 hours

Children 1-12 years

50-100 mg rapid intravenous (IV) bolus, then 50 mg/m²/day by continuous IV drip or divided every 6-8 hours

Alternative: 1-2 mg/kg IV bolus, then 150-250 mg/day divided every 6-8 hours

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is A-Hydrocort Injection available?

  • Hydrocort Injectionis available in the following dosage forms and strengths:
  • Injection,
  • Powder, lyophilized, for solution

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services or go to your nearest emergency room.

What should I do if I miss a dose?

If you miss a dose of A-Hydrocort Injection, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Review Date: November 2, 2018 | Last Modified: September 12, 2019

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