Generic Name: Streptase Brand Name(s): Generics only. No brands available.


What is Streptase® (Streptokinase) used for?

Streptase® is commonly used for dissolving blood clots that have formed in the blood vessels. It is immediately used after symptoms of heart attack to improve patient survival. This medicine may be used to treat blood clots in the lungs (pulmonary embolism) and in the legs (deep venous thrombosis).

Besides, streptokinase is used to dissolve blood clots in tubes (catheters) that are inserted in blood vessels.

Streptase® may be prescribed for other uses. Ask your doctor or pharmacist for more information.

How should I take Streptase® (Streptokinase)?

Streptase® is given through a needle or tube placed into one of your blood vessels. It will be given by a doctor or other trained health professional.

How do I store Streptase® (Streptokinase)?

Streptase® is best stored in the refrigerator. To prevent drug damage, do not freeze. There may be different brands of Streptase® that may have different storage needs. It is important to always check the product package for instructions on storage, or ask your pharmacist. For safety, you should keep all medicines away from children and pets.

You should not flush Streptase® down the toilet or pour them into a drain unless instructed to do so. It is important to properly discard this product when it is expired or no longer needed. Consult your pharmacist for more details about how to safely discard your product.

Precautions & warnings

What should I know before using Streptase® (Streptokinase)?

Consult with your doctor or pharmacist, if:

  • You are pregnant or breastfeeding. This is because, while you are expecting or feeding a baby, you should only take medicines on the recommendation of a doctor.
  • You are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • You have allergy with any of active or inactive ingredients of Streptase® or other medications.
  • You have any other illnesses, disorders, or medical conditions.

Is it safe during pregnancy or breastfeeding?

There are no adequate studies in women for determining risk when using Streptase® during pregnancy or while breastfeeding. Please always consult with your doctor to weigh the potential benefits and risks before taking Streptase®. Streptase® is pregnancy risk category C, according to the US Food and Drug Administration (FDA).

FDA pregnancy risk category reference below:

  • A=No risk;
  • B=No risk in some studies;
  • C=There may be some risk;
  • D=Positive evidence of risk;
  • X=Contraindicated;
  • N=Unknown.

Always consult your health care provider prior to using Streptase® if you are pregnant, breastfeeding.

Side effects

What side effects can occur from Streptase® (Streptokinase)?

Streptase® may cause these side effects, such as:

  • Fever;
  • Chills;
  • Back pain;
  • Abdominal pain;
  • Nausea;
  • Vomiting;
  • Arrhythmia;
  • Bruising;
  • Rash;
  • Pruritus;
  • Acute renal failure due to embolism and hemorrhage;
  • Cerebral, peripheral and pulmonary embolism;
  • Allergic reactions;
  • Liver enzyme abnormalities;
  • Hypotension;
  • Potentially fatal: hemorrhage, anaphylactic shock.

Not everyone experiences these side effects. There may be some side effects not listed above. If you have any concerns about a side effect, please consult your doctor or pharmacist.


What drugs may interact with Streptase® (Streptokinase)?

Streptase® may interact with other drugs that you are currently taking, which can change how your drug works or increase your risk for serious side effects. To avoid any potential drug interactions, you should keep a list of all the drugs you are using (including prescription drugs, nonprescription drugs, and herbal products) and share it with your doctor and pharmacist. For your safety, do not start, stop, or change the dosage of any drugs without your doctor’s approval.

Streptase® combine with antiplatelet agents and anticoagulants, may cause bleeding complications.

Does food or alcohol interact with Streptase® (Streptokinase)?

Streptase® may interact with food or alcohol by altering the way the drug works or increase the risk for serious side effects. Please discuss with your doctor or pharmacist any potential food or alcohol interactions before using this drug.

What health conditions may interact with Streptase® (Streptokinase)?

Streptase® may interact with your health condition. This interaction may worsen your health condition or alter the way the drug works. It is important to always let your doctor and pharmacist know all the health conditions you currently have.

  • Bleeding problems or a history of bleeding in any part of the body;
  • Blood clotting disorder, uncontrolled;
  • Brain disease or tumor;
  • High blood pressure or low blood pressure;
  • Stroke (within two months);
  • Avoid using Streptase® in these conditions: surgery or injury to the brain or spine within two months.
  • Catheter (tube) infection;
  • Diabetes mellitus and eye problems from diabetes;
  • Heart disease or infections;
  • Severe kidney disease;
  • Severe liver disease;
  • Lung disease;
  • Pancreatitis;
  • Placement of any tube into the body;
  • Heart rhythm problems;
  • Recent Streptococcal infection.


The information provided is not a substitute for any medical advice. You should ALWAYS consult with your doctor or pharmacist before using this medication.

What is the dose of Streptase® (Streptokinase) for an adult?

Acute myocardial infarction by intravenous infusion:

1.5 million units as a single dose infused over 1 hour immediately after onset of symptoms.

Acute myocardial infarction by intracoronary infusion:

Total dose: 140,000 IU.

20,000 IU by bolus followed by 2,000 IU/min. For 60 min.

Pulmonary thromboembolism, arteriovenous occlusions by intravenous infusion:

Loading dose: 250,000 units/30 min.

Maintenance dose: 100,000 units/hour, for 24-72 hours.

Deep vein thrombosis by intravenous infusion:

Loading dose: 250,000 IU/30 min.

Maintenance dose: 100,000 IU/hour, for 72 hours.

Arterial thrombosis or embolism by intravenous infusion:    

Loading dose: 250,000 IU/30min.

Maintenance dose: 100,000 IU/hour, for 24-72 hours.

What is the dose of Streptase® (Streptokinase) for a child?

The dosage has not been established in pediatric patients. It may be unsafe for your child. It is always important to fully understand the safety of the drug before using. Please consult with your doctor or pharmacist for more information.

How is Streptase® (Streptokinase) available?

Streptase® is available in the following dosage forms and strengths:

  • Streptase® lyophilized white powder in 50 ml infusion bottles (1,500,000 IU).
  • Streptase® lyophilized white powder in 6.5 ml vials (Label green: 250,000 IU; Label blue: 750,000 IU; Label red: 1,500,000).

What should I do in case of an emergency or overdose?

In case of an emergency or an overdose, call your local emergency services (115) or go to your nearest emergency room.

It is also important to carry a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking with you in case of emergencies.

What should I do if I miss a dose?

If you miss a dose of Streptase®, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your regular dose as scheduled. Do not take a double dose.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Review Date: November 22, 2016 | Last Modified: January 4, 2017

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