Young syndrome



What is Young syndrome?

Young syndrome (YS) or Young’s syndrome is a well-known disease observed in the early age of young males. It is a rare medical condition, characterized by a triad of symptoms such as bronchiectasis, sinusitis and obstructive azoospermia. It shows similarity to cystic fibrosis. Young syndrome is an autosomal recessive inherited genetic defect.

Young syndrome is named after Dr. Donald Young, who first observed the clinical signs of this syndrome in a group of male patients showing infertility associated with recurrent respiratory problems. It is also called as Barry-Perkins-Young syndrome, named after his first two patients.

How common is Young syndrome?

Young’s syndrome is a rare genetic disorder. It is typically diagnosed in middle-aged men who undergo evaluation for infertility.

Young syndrome was very common in 1980. An estimated 1 in 500 males were found to be affected by Young syndrome.  It can be managed by reducing your risk factors. Please discuss with your doctor for further information.


What are the symptoms of Young syndrome?

The common symptoms of Young syndrome are:

  • Decreased fertility
  • Obstructive azoospermia
  • Recurrent bronchitis
  • Recurrent sinopulmonary infections
  • Abnormality of the pancreas
  • Autosomal recessive inheritance
  • Azoospermia
  • Bronchiectasis
  • Congenital cystic adenomatoid malformation of the lung
  • Sinusitis
  • Clubbing of fingers and toes

Generally, symptoms of sinusitis disappear during adolescence; while other symptoms of Young syndrome persist.

There may be some symptoms not listed above. If you have any concerns about a symptom, please consult your doctor.

When should I see my doctor?

If you have any signs or symptoms listed above or have any questions, please consult with your doctor. Everyone’s body acts differently. It is always best to discuss with your doctor what is best for your situation.


What causes Young syndrome?

The exact cause of Young syndrome has not been identified.

Risk factors

What increases my risk for Young syndrome?

Several studies have shown that Young syndrome is caused due to exposure to mercury. Earlier, Mercurous chloride was used in toothpastes and worm medications in UK.

Genetic factors are also believed to cause Young syndrome.

Please consult with your doctor for further information.

Diagnosis & treatment

The information provided is not a substitute for any medical advice. ALWAYS consult with your doctor for more information.

How is Young syndrome diagnosed?

Clinical diagnosis of Young syndrome is as follows:

  • Patients showing symptoms of both sinusitis and infertility are well examined.
  • Patients with prolonged mucociliary clearance are evaluated. Saccharine placed over inferior turbinate takes double time than normal to reach nasopharynx and posterior 1/3rd of the tongue.
  • Pulmonary function test to check if air passes through lungs in a smooth or obstructed way.
  • Semen sample is collected to check for the sperm motility and structural abnormalities.
  • Imaging methods such as X-ray and Computed tomography scans are used to look for lung infection and sinus malformations.

How is Young syndrome treated?

There is no specific treatment for Young syndrome. However, the condition is managed in the following method:

  • Control of infections with antibiotics and bronchodilators.
  • Hormonal supplementation for treatment of azoospermia.
  • Microsurgical techniques are used to restore fertility in these patients; however, it has shown limited success.

Lifestyle changes & home remedies

What are some lifestyle changes or home remedies that can help me manage Young syndrome?

Few men who suffer from Young syndrome lead a very difficult life. Hence, they need both medical treatment to alleviate the symptoms and an emotional support to cope up with the emotional ups and downs in everyday life.

If you have any questions, please consult with your doctor to better understand the best solution for you.

Hello Health Group does not provide medical advice, diagnosis or treatment.


Review Date: January 25, 2018 | Last Modified: January 25, 2018

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