What is peyronie's disease?


Know the basics

What is Peyronie’s disease?

Peyronie’s disease is condition caused scar tissues inside penis and testicles. Scar tissues build up in white membrane which is often at the top and base of the penis. Due to increasingly thick scar tissue, the penis will then be bent or lean.

Penis curvature or deviation can cause pain during having sex, even inability of having sex. Penis swelling and inflammation of Peyronie disease increase risk of permanent hard scarring on the penis.

Scar tissues of Peyronie’s disease unlike developed abnormal tissue in artery (causing stenosis), but they are benign cystic fibrous tissue (noncancerous). Peyronie disease is not contagious and does not spread through sexual contact. Many men erect with bent penis. Peyronie disease makes it worse. Stimulation of penis leads to formation of scar tissues as penile curvature, hindering penetration during sex.

How common is Peyronie’s disease?

Young men, especially those who are at high risk of penis injury, such as athletes often have Peyronie’s disease. It can be managed by reducing your risk factors. Please discuss with your doctor for further information.

Know the symptoms

What are the symptoms of Peyronie’s disease?

The signs and symptoms of Peyronie’s disease may appear suddenly or develop slowly. The most common signs and symptoms include:

  • Callus: scar tissues (plaques) can be felt under the skin of the penis as flat lumps or a hard tissue strip.
  • Penis bends greatly: penis can be bent up, down or sideways.
  • Erection problem: Peyronie’s disease can cause erectile dysfunction.
  • Penis is shortened: Your penis may be shorter as a result of Peyronie’s disease.
  • Pain: You may have pain in your penis when erecting.

When should I see my doctor?

If you feel pain or bent penis hindering sexual activity or have any questions, please consult with your doctor. Everyone’s body acts differently. It is always best to discuss with your doctor what is best for your situation.

Know the causes

What causes Peyronie’s disease?

Causes of Peyronie’s disease are still unknown. However, some researchers believe that the disease may result from repeated trauma. For example, the penis may be damaged during sex, exercise or by accident. During recovery trauma, scar tissues can form disorderly causing development in penile curvature.

In addition, some researchers believe Peyronie’s disease may have several causes of autoimmune diseases. Normally the immune system protects our body from infection by identifying and killing bacteria, viruses and other foreign substances that may harm others when they invade. When you have autoimmune disease, the immune system can confuse and attack healthy cells of the body, so Peyronie’s disease can develop candles cell in damaged penis and cause inflammation and scar.

Know the risk factors

What increases my risk for Ppeyronie’s disease?

Small injuries in your penis do not always cause Peyronie disease. However, there are a number of different factors which may contribute to accumulation of scar tissue in the healing process, such as:

  • Heredity: if your father or brother has Peyronie disease, you are also at risk.
  • Connective tissue disorders: patients with connective tissue disorders are at high risk Peyronie disease.
  • Age: Peyronie disease incidence increased with age. Age-related changes can make them susceptible and difficult to heal.

Other factors include health conditions; smoking and certain types of prostate surgery can also involve Peyronie disease.

Understand the diagnosis & treatment

The information provided is not a substitute for any medical advice. ALWAYS consult with your doctor for more information.

How is Peyronie’s disease diagnosed?

Your doctor will diagnose and find the cause of Peyronie disease in the following ways:

  • Physical exam: Your doctor will check your penis when it does not erect to determine location and amount of scar tissues. If this situation continues deteriorating, the initial diagnosis will determine whether penis was shortened yet.
  • Your doctor may also ask to see erect penis, and determine curvature, location of scar tissues or other details.
  • Other tests: ultrasound when erection is commonly used. This test can indicate presence of scar tissues, blood flow to the penis and other abnormalities.

How is Peyronie’s disease treated?


Your doctor may prescribe some medications to reduce curvature, size of scars and inflammation of your penis. These medications may be taken orally or injected directly into scars in your penis.

Oral drugs include:

  • Vitamin E;
  • Potassium para-aminobenzoate (Potaba);
  • Tamoxifen;
  • Colchicine;
  • Acetyl-L-carnitine;
  • Pentoxifylline.

Injectable drugs include:

  • Verapamil;
  • Interferon alpha 2b;
  • Steroids;
  • collagenase (Xiaflex).


Doctors usually recommend surgery method when the penis is deformed too seriously, especially it causes uncomfortable or you cannot have sex. In addition, surgery is usually not recommended until the curvature of your penis stops growing. There are three surgical methods for treatment: Sewing corrugated corpora, slitting/cutting plaques and patches cover, put artificial corpora.

Some other methods:

  • Ionisation therapy uses a weak electrical current to give a percutaneous verapamil and dexamethasone through skin.
  • Use high-intensity sound waves to break up the scar tissues (shock wave therapy).
  • Using devices to lengthen the penis (penile traction therapy).
  • Use vacuum equipment.

Lifestyle changes & home remedies

What are some lifestyle changes or home remedies that can help me manage Peyronie’s disease?

You should maintain a healthy lifestyle through proper sports activities, limiting alcoholic beverages, tobacco and stimulants… Besides, you should also improve relationship with your spouse, have healthy sexuality and health care for the prevention and timely treatment.

If you have any questions, please consult with your doctor to better understand the best solution for you.

Hello Health Group does not provide medical advice, diagnosis or treatment.

msBahasa Malaysia

Review Date: December 18, 2016 | Last Modified: January 4, 2017