Fakta Disemak oleh Hello Doktor Medical Panel
Pellagra is a disease characterised by diarrhoea, dermatitis and dementia. If left untreated, death is the usual outcome. It occurs as a result of niacin (vitamin B-3) deficiency. Niacin is required for most cellular processes. Since tryptophan in the diet can be converted to niacin in the body, both of these need to be deficient for pellagra to develop.
Please discuss with your doctor for further information.
The common symptoms of pellagra are:
There may be some symptoms not listed above. If you have any concerns about a symptom, please consult your doctor.
If you have any signs or symptoms listed above or have any questions, please consult with your doctor. Everyone’s body acts differently. It is always best to discuss with your doctor what is best for your situation.
Pellagra is caused by a deficiency in niacin. This can occur in 2 ways:
Please discuss with your doctor for further information.
The information provided is not a substitute for any medical advice. ALWAYS consult with your doctor for more information.
After niacin has been processed it can be excreted in the urine. The products detected in the urine include nicotinic acid, niacin oxide and metabolites including 2-pyridone and 2-methyl nicotinamide.
The latter two metabolites can be measured to assess niacin deficiency (low levels will be present).
RBC levels of NAD/NADP can also be useful in the diagnosis.
Pellagra can be effectively cured with intravenous or oral niacin or nicotinamide.
An improvement in primary pellagra should be seen within two days of commencing treatment. A high protein diet supplemented with B-group vitamins is needed for complete recovery. Secondary pellagra may be harder to treat in view of its possible causes.
Skin lesions may be treated with topical emollients. Sun protection is important during the recovery phase. Cover up and apply a broad spectrum sunscreen to all exposed areas daily.
The following lifestyles and home remedies might help you cope with pellagra:
If you have any questions, please consult with your doctor to better understand the best solution for you.
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