What is non-Hodgkin lymphoma?
Non-Hodgkin’s lymphoma, also called non-Hodgkin lymphoma, is cancer that originates in your lymphatic system, the disease-fighting network spread throughout your body. In non-Hodgkin’s lymphoma, tumors develop from lymphocytes — a type of white blood cell.
How common is non-Hodgkin lymphoma?
Non-Hodgkin lymphoma can affect patients at any age. It can be managed by reducing your risk factors. Please discuss with your doctor for further information.
What are the symptoms of non-Hodgkin lymphoma?
The common symptoms of non-Hodgkin lymphoma are:
- Painless, swollen lymph nodes in your neck, armpits or groin
- Abdominal pain or swelling
- Chest pain, coughing or trouble breathing
- Night sweats
- Weight loss
There may be some symptoms not listed above. If you have any concerns about a symptom, please consult your doctor.
When should I see my doctor?
If you have any signs or symptoms listed above or have any questions, please consult with your doctor. Everyone’s body acts differently. It is always best to discuss with your doctor what is best for your situation.
What causes non-Hodgkin lymphoma?
Doctors aren’t sure what causes non-Hodgkin’s lymphoma.
Non-Hodgkin’s lymphoma occurs when your body produces too many abnormal lymphocytes — a type of white blood cell.
Normally, lymphocytes go through a predictable life cycle. Old lymphocytes die, and your body creates new ones to replace them. In non-Hodgkin’s lymphoma, your lymphocytes don’t die, but continue to grow and divide. This oversupply of lymphocytes crowds into your lymph nodes, causing them to swell.
Non-Hodgkin’s lymphoma can begin in the:
- B cells. B cells fight infection by producing antibodies that neutralize foreign invaders. Most non-Hodgkin’s lymphoma arises from B cells. Subtypes of non-Hodgkin’s lymphoma that involve B cells include diffuse large B-cell lymphoma, follicular lymphoma, mantle cell lymphoma and Burkitt lymphoma.
- T cells. T cells are involved in killing foreign invaders directly. Non-Hodgkin’s lymphoma occurs less often in T cells. Subtypes of non-Hodgkin’s lymphoma that involve T cells include peripheral T-cell lymphoma and cutaneous T-cell lymphoma.
Whether your non-Hodgkin’s lymphoma arises from your B cells or T cells helps to determine your treatment options.
Non-Hodgkin’s lymphoma generally involves the presence of cancerous lymphocytes in your lymph nodes, but the disease can also spread to other parts of your lymphatic system. These include the lymphatic vessels, tonsils, adenoids, spleen, thymus and bone marrow. Occasionally, non-Hodgkin’s lymphoma involves organs outside of your lymphatic system.
What increases my risk for non-Hodgkin lymphoma?
There are many risk factors for non-Hodgkin lymphoma, such as:
- Medications that suppress your immune system. If you’ve had an organ transplant, you’re more susceptible because immunosuppressive therapy has reduced your body’s ability to fight off new illnesses.
- Infection with certain viruses and bacteria. Certain viral and bacterial infections appear to increase the risk of non-Hodgkin’s lymphoma. Viruses linked to increased non-Hodgkin’s lymphoma risk include HIV and Epstein-Barr virus. Bacteria linked to an increased risk of non-Hodgkin’s lymphoma include the ulcer-causing Helicobacter pylori.
- Certain chemicals, such as those used to kill insects and weeds, may increase your risk of developing non-Hodgkin’s lymphoma. More research is needed to understand the possible link between pesticides and the development of non-Hodgkin’s lymphoma.
- Older age. Non-Hodgkin’s lymphoma can occur at any age, but the risk increases with age. It’s most common in people in their 60s or older.
Diagnosis & treatment
The information provided is not a substitute for any medical advice. ALWAYS consult with your doctor for more information.
How is non-Hodgkin lymphoma diagnosed?
Tests and procedures used to diagnose non-Hodgkin’s lymphoma include:
- Physical examination. Your doctor may conduct a physical exam to determine the size and condition of your lymph nodes and to find out whether your liver and spleen are enlarged.
- Blood and urine tests. Blood and urine tests may help rule out an infection or other disease.
- Imaging tests. Your doctor may recommend imaging tests to look for tumors in your body. Imaging tests may include X-ray, computerized tomography (CT) scan, magnetic resonance imaging (MRI) or positron emission tomography (PET).
- Removing a sample of lymph node tissue for testing. Your doctor may recommend a biopsy procedure to sample or remove a lymph node for testing. Analyzing lymph node tissue in a lab may reveal whether you have non-Hodgkin’s lymphoma and, if so, which type.
- Looking for cancer cells in your bone marrow. To find out whether the disease affects your bone marrow, your doctor may request a bone marrow biopsy. This involves inserting a needle into your pelvic bone to obtain a sample of bone marrow.
How is non-Hodgkin lymphoma treated?
Your treatment options are determined based on the type and stage of your lymphoma, your age, and your overall health.
Treatment isn’t always necessary. If your lymphoma appears to be slow growing (indolent), a wait-and-see approach may be an option. Indolent lymphomas that don’t cause signs and symptoms may not require treatment for years. Delaying treatment doesn’t mean you’ll be on your own. Your doctor will likely schedule regular checkups every few months to monitor your condition and ensure that your cancer isn’t advancing.
If your non-Hodgkin’s lymphoma is aggressive or causes signs and symptoms, your doctor may recommend treatment. Options may include:
- Chemotherapy is drug treatment — given orally or by injection — that kills cancer cells. Chemotherapy drugs can be given alone, in combination with other chemotherapy drugs or combined with other treatments.
- Radiation therapy. Radiation therapy uses high-powered energy beams, such as X-rays, to kill cancerous cells and shrink tumors. During radiation therapy, you’re positioned on a table and a large machine directs radiation at precise points on your body. Radiation therapy can be used alone or in combination with other cancer treatments.
- Stem cell transplant. A stem cell transplant is a procedure that involves very high doses of chemotherapy or radiation with the goal of killing the lymphoma cells that may not be killed with standard doses. Later, healthy stem cells — your own or from a donor — are injected into your body, where they can form new healthy blood cells.
- Medications that enhance your immune system’s ability to fight cancer. Biological therapy drugs help your body’s immune system fight cancer. For example, one biological therapy called rituximab (Rituxan) is a type of monoclonal antibody that attaches to B cells and makes them more visible to the immune system, which can then attack. Rituximab lowers the number of B cells, including your healthy B cells, but your body produces new healthy B cells to replace these. The cancerous B cells are less likely to recur.
- Medications that deliver radiation directly to cancer cells. Radioimmunotherapy drugs are made of monoclonal antibodies that carry radioactive isotopes. This allows the antibody to attach to cancer cells and deliver radiation directly to the cells. One radioimmunotherapy drug — ibritumomab tiuxetan (Zevalin) — is used to treat lymphoma.
Lifestyle changes & Home remedies
What are some lifestyle changes or home remedies that can help me manage non-Hodgkin lymphoma?
The following lifestyles and home remedies might help you cope with non-Hodgkin lymphoma:
- Learn enough about lymphoma to make decisions about your care. Ask your doctor about your non-Hodgkin’s lymphoma, including your treatment options and, if you like, your prognosis. As you learn more about non-Hodgkin’s lymphoma, you may become more confident in making treatment decisions.
- Keep friends and family close. Keeping your close relationships strong will help you deal with your non-Hodgkin’s lymphoma. Friends and family can provide the practical support you’ll need, such as helping take care of your house if you’re in the hospital. And they can serve as emotional support when you feel overwhelmed by cancer.
- Find someone to talk with. Find a good listener with whom you can talk about your hopes and fears. This may be a friend or family member. The concern and understanding of a counselor, medical social worker, clergy member or cancer support group also may be helpful.
- Ask your doctor about support groups in your area.
If you have any questions, please consult with your doctor to better understand the best solution for you.
Hello Health Group does not provide medical advice, diagnosis or treatment.
- Non-Hodgkin's lymphoma. http://www.mayoclinic.org/diseases-conditions/non-hodgkins-lymphoma/basics/definition/con-20027792. Accessed 15 Jan 2017
- What is non-Hodgkin lymphoma? http://www.cancer.org/cancer/non-hodgkinlymphoma/detailedguide/non-hodgkin-lymphoma-what-is-non-hodgkin-lymphoma. Accessed 15 Jan 2017
Review Date: June 25, 2017 | Last Modified: June 25, 2017