Lyell’s syndrome



What is Lyell’s syndrome?

Allergic diseases have different effects on the body in its consequences. The most severe outcome is Lyell’s syndrome. This condition is life-threatening, it is characterized by necrotic changes in the epidermis – the top layer of the skin and, later, his detachment. Necrosis caused by toxic effects of allergens caught in the body, resulting in the characteristic symptoms of the disease appear.

How common is Lyell’s syndrome?

Please discuss with your doctor for further information.


What are the symptoms of Lyell’s syndrome?

The reaction of the organism to a foreign substance in the Lyell syndrome is developing quite rapidly, within a few days. There was a sharp rise in temperature to high numbers, then there are rashes that cover the whole body. After just a few days on the skin blisters are formed, resembling the clinical picture after extensive burns. The epidermis peels off places on the body there are numerous hemorrhages.

In addition to the skin, the syndrome of Lyell damaged mucous membranes. This not only exterior – lips, conjunctiva, genitals, and the shell of the internal organs. Eruptions on the mucous lead to the development of inflammatory processes in the field of defeat.

The phenomena of intoxication in Lyell’s syndrome is increasing rapidly. Against the background of high temperature quickly comes dehydration, which is characterized by weakness, drowsiness, disorientation. The blood thickens, which leads to the difficulty of its movement through the vessels and the disruption of the internal organs in the first place – the heart, kidneys, liver.

There may be some symptoms not listed above. If you have any concerns about a symptom, please consult your doctor.

When should I see my doctor?

If you or your loved one has any signs or symptoms listed above or you have any questions, please consult with your doctor. Everyone’s body acts differently. It is always best to discuss with your doctor what is best for your situation.


What causes Lyell’s syndrome?

An important role in the development of any allergic diseases including Lyell syndrome, drugs play. It is believed that the particular organism causing the reaction in the first place, the antibacterial agents. However, the allergy can be triggered by any of the drugs. There it is usually at an elevated sensitivity of the person to substances that act on it.

Lyell’s syndrome, or epidermal necrolysis, differs from other allergic diseases genesis. For most of them characterized by the body’s reaction directly to the substance introduced into it. When this syndrome also occurs compound allergen proteins present in the cells of the epidermis, which makes the top layer of skin “foreign” to the body and leads to its rejection. It is with this strong immune response associated person even seemingly innocuous drug.

As a result, the disease is rapid protein breakdown products which accumulate in the body and have a toxic effect on him. Lyell’s syndrome has a high percentage of mortality, which is due to the swiftness and severity of the body.

Risk factors

What increases my risk for Lyell’s syndrome?

Children who have just emerged into the light, face many pathogenic factors of the environment. It can induce various diseases among them. However, the immunity obtained from the mother, protects babies, so as severe allergic disease, which is the Lyell’s syndrome, the newborn is very rare.

Note that in adult epidermal necrolysis develops after medication, sometimes – after transfusions of blood and blood components – plasma. For children is more typical of early childhood development is Lyell’s syndrome on the background of a staph infection. An important role in causing the disease is the presence of hereditary allergic readiness.

In connection with the early age children, epidermal necrolysis has a very severe course and is characterized by acute onset. Lyell’s syndrome in infants grow rapidly. Symptoms of intoxication defeat almost the entire surface of the skin and this may contribute to sepsis. However, the percentage of recovery in young children, in time begun treatment is significantly higher than in adults.

Please consult with your doctor for further information.

Diagnosis & treatment

The information provided is not a substitute for any medical advice. ALWAYS consult with your doctor for more information.

How is Lyell’s syndrome diagnosed?

Please consult with your doctor for further information.

How is Lyell’s syndrome treated?

The appearance of the first signs of Lyell’s syndrome requires immediate hospitalization. In this disease the timeliness of care plays a crucial role in saving the patient’s life. Therapeutic measures are aimed primarily at fighting intoxication. In addition, it is necessary to normalize the water-salt balance, blood circulation and the functioning of vital organs.

Lyell’s syndrome treatment necessarily involves local impact on the affected skin. In order to apply these special drugs as aerosols, which promote healing of skin defects. For the oral mucosa is also used rinsing or irrigation decoction of herbs. Very important is caring for patients with the syndrome of Lyell. It is based on the principle of doing burn patients. They require only sterile dressings and linen in the House, equipped with bactericidal lamps must be maintained a certain temperature.

In very severe course of Lyell’s syndrome treatment of the disease contributes to the use of plasmapheresis. This procedure has two effects on the direction. First – deducing from it the toxic substances, and the second – normalization of the immune system, which, in the aggregate, promotes recovery.

The unpredictability of the body’s response to the impact of any substances largely complicates the prevention of allergic diseases. However, given the seriousness of the consequences of many of them, such as Lyell’s syndrome, you must take responsibility for their own health. If you have an allergic reaction should not self-medicate, as this can lead to very negative consequences.

Lifestyle changes & home remedies

What are some lifestyle changes or home remedies that can help me manage Lyell’s syndrome?

If you have any questions, please consult with your doctor to better understand the best solution for you.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Review Date: March 23, 2018 | Last Modified: March 23, 2018