Idiopathic thrombocytopenic purpura (ITP)

By Medically reviewed by hellodoktor

Definition

What is idiopathic thrombocytopenic purpura (ITP)?

Idiopathic thrombocytopenic purpura (ITP)—also known as immune thrombocytopenic purpura, is a disorder that can lead to easy or excessive bruising and bleeding. The bleeding results from unusually low levels of platelets — the cells that help blood clot.

How common is idiopathic thrombocytopenic purpura (ITP)?

This idiopathic thrombocytopenic purpura (ITP) is extremely common. It commonly affects more females than males. It can affect patients at any age. It can be managed by reducing your risk factors. Please discuss with your doctor for further information.

Symptoms

What are the symptoms of idiopathic thrombocytopenic purpura (ITP)?

Idiopathic thrombocytopenic purpura (ITP) may have no signs and symptoms. When they do occur, they may include:

  • Easy or excessive bruising (purpura)
  • Superficial bleeding into the skin that appears as a rash of pinpoint-sized reddish-purple spots (petechiae), usually on the lower legs
  • Bleeding from the gums or nose
  • Blood in urine or stools
  • Unusually heavy menstrual flow

There may be some symptoms not listed above. If you have any concerns about a symptom, please consult your doctor.

When should I see my doctor?

If you have any signs or symptoms listed above or have any questions, please consult with your doctor. Everyone’s body acts differently. It is always best to discuss with your doctor what is best for your situation.

Bleeding that won’t stop is a medical emergency. Seek immediate help if you or your child experiences bleeding that can’t be controlled by the usual first-aid techniques, such as applying pressure to the area.

Causes

Causes

What causes idiopathic thrombocytopenic purpura (ITP)?

In some people thrombocytopenia is caused by the immune system mistakenly attacking and destroying platelets. If the cause of this immune reaction is unknown, the condition is called idiopathic thrombocytopenic purpura. Idiopathic means “of unknown cause.”

In most children with ITP, the disorder follows a viral illness, such as the mumps or the flu. It may be that the infection triggers the immune system malfunction.

Risk factors

What increases my risk for idiopathic thrombocytopenic purpura (ITP)?

There are many risk factors for idiopathic thrombocytopenic purpura (ITP), such as:

  • Your sex. Women are two to three times more likely to develop ITP than men are.
  • Recent viral infection. Many children with ITP develop the disorder after a viral illness, such as mumps, measles or a respiratory infection.

Diagnosis & treatment

The information provided is not a substitute for any medical advice. ALWAYS consult with your doctor for more information.

How is idiopathic thrombocytopenic purpura (ITP) diagnosed?

To diagnose idiopathic thrombocytopenic purpura, your doctor will try to exclude other possible causes of bleeding and a low platelet count, such as an underlying illness or medications you or your child may be taking.

Your doctor will also ask you about your or your child’s medical history, perform a physical exam and run one or more of the following tests:

  • Complete blood count (CBC). This common blood test is used to determine the number of blood cells, including platelets, in a sample of blood. With ITP, white and red blood cell counts are usually normal, but the platelet count is low.
  • Blood smear. This test is often used to confirm the number of platelets observed in a complete blood count. A sample of blood is placed on a slide and observed under a microscope.
  • Bone marrow exam. This test may be used to help identify the cause of a low platelet count, though the American Society of Hematology doesn’t recommend this test for children with ITP.Platelets are produced in the bone marrow — soft, spongy tissue in the center of large bones. In some cases, a sample of bone tissue and the enclosed marrow is removed in a procedure called a bone marrow biopsy. Or your doctor may do a bone marrow aspiration, which removes some of the liquid portion of the marrow. In many cases, both procedures are performed at the same time (bone marrow exam).

How is idiopathic thrombocytopenic purpura (ITP) treated?

People with mild idiopathic thrombocytopenic purpura may need nothing more than regular monitoring and platelet checks. Children usually improve without treatment. Most adults with ITP will eventually need treatment, as the condition often becomes severe or long-term (chronic) ITP.

Treatment may include a number of approaches, such as medications to boost your platelet count or surgery to remove your spleen (splenectomy). Talk with your doctor about the risks and benefits of your treatment options. Some people find that the side effects of treatment are more burdensome than the effects of the disease itself.

Medications

Your doctor will talk with you about medications or supplements you take and whether you need to stop using any that might inhibit platelet function. Examples include aspirin, ibuprofen (Advil, Motrin IB, others), ginkgo biloba and warfarin (Coumadin).

Your doctor may prescribe one or more of the following medications to treat ITP:

  • Drugs that suppress your immune system. Your doctor will likely start you on an oral corticosteroid, such as prednisone. This drug may help raise your platelet count by decreasing the activity of your immune system. Once your platelet count is back to a safe level, you can gradually discontinue taking the drug under the direction of your doctor. In general, this takes about two to six weeks.The problem is that many adults experience a relapse after discontinuing corticosteroids. A new course of corticosteroids may be pursued, but long-term use of these medications isn’t recommended because of the risk of serious side effects. These include cataracts, high blood sugar, increased risk of infections and thinning of bones (osteoporosis).
  • Injections to increase your blood count. If corticosteroids don’t help, your doctor may give you an injection of immune globulin (IVIG). This drug may also be used if you have critical bleeding or need to quickly increase your blood count before surgery. The effect usually wears off in a couple of weeks. Possible side effects include headache, vomiting and low blood pressure.
  • Drugs that boost platelet production. Thrombopoietin receptor agonists — such as romiplostim (Nplate) and eltrombopag (Promacta) — help your bone marrow produce more platelets. Possible side effects include headache, dizziness, nausea or vomiting, and an increased risk of blood clots.
  • Other immune-suppressing drugs. Rituximab (Rituxan) helps reduce the immune system response that’s damaging platelets, thus raising the platelet count. Possible side effects include low blood pressure, fever, sore throat and rash.

Emergency treatment

Although rare, severe bleeding can occur with ITP. Emergency care usually includes transfusions of platelet concentrates, intravenous corticosteroid (methylprednisolone) and intravenous immune globulin.

Treatments for resistant disease

If your condition persists despite treatment, your doctor may suggest other drugs that suppress the immune system or boost platelet production:

  • Removal of your spleen. If your condition is severe or persists despite initial drug treatment, your doctor may suggest surgical removal of your spleen (splenectomy). This quickly eliminates the main source of platelet destruction in your body and improves your platelet count, though it doesn’t work for everyone. Serious post-surgical complications sometimes occur, and not having a spleen permanently increases your susceptibility to infection.Splenectomy is rarely a treatment choice for children with ITP because they often get better without treatment.
  • Other drugs. Azathioprine (Imuran, Azasan) has been used to treat ITP. But it can cause significant side effects, and its effectiveness has yet to be proved. Possible side effects include fever, headache, nausea and vomiting, and muscle pain.

Lifestyle changes & Home remedies

What are some lifestyle changes or home remedies that can help me manage idiopathic thrombocytopenic purpura (ITP)?

The following lifestyles and home remedies might help you cope with idiopathic thrombocytopenic purpura (ITP):

  • Avoid activities that could cause injury. Ask your doctor which activities are safe for you. Contact sports — such as boxing, martial arts and football — carry a high risk of injury.
  • Drink alcohol in moderation, if at all. Alcohol slows the production of platelets in your body. Ask your doctor whether it’s OK for you to drink alcohol.
  • Watch for signs of infection. If you’ve had your spleen removed, be alert for any signs of infection, including fever, and seek prompt treatment. Infection in someone who has had a splenectomy may be more severe than in someone who still has a spleen.
  • Use caution with over-the-counter medications. Nonprescription drugs such as aspirin and ibuprofen (Advil, Motrin IB, others) can impair platelet function.

If you have any questions, please consult with your doctor to better understand the best solution for you.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: June 19, 2017 | Last Modified: September 11, 2019

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