What is Hyperlipoproteinemia?

Hyperlipoproteinemia is a condition results from an inability to break down lipids or fats in your body, specifically cholesterol and triglycerides. There are several types of hyperlipoproteinemia. The type depends on the concentration of lipids and which are affected. There are five types of primary hyperlipoproteinemia:

  • Type 1 is an inherited condition. It causes the normal breakdown of fats in your body to be disrupted. A large amount of fat builds up in your blood as a result.
  • Type 2 runs in families. It’s characterized by an increase of circulating cholesterol, either low-density lipoproteins (LDL) alone or with very-low-density lipoproteins (VLDL). These are considered the “bad cholesterols.”
  • Type 3 is a recessively inherited disorder in which intermediate-density lipoproteins (IDL) accumulate in your blood. IDL has a cholesterol-to-triglycerides ratio that’s higher than that for VLDL. This disorder results in high plasma levels of both cholesterol and triglycerides.
  • Type 4 is a dominantly inherited disorder. It’s characterized by high triglycerides contained in VLDL. The levels of cholesterol and phospholipids in your blood usually remain within normal limits.
  • Type 5 runs in families. It involves high levels of LDL alone or together with VLDL.

How common is Hyperlipoproteinemia?

Please discuss with your doctor for further information.


What are the symptoms of Hyperlipoproteinemia?

Lipid deposits are the main symptom of hyperlipoproteinemia. The location of lipid deposits can help to determine the type. Some lipid deposits, called xanthomas, are yellow and crusty. They occur on your skin.

Many people with this condition experience no symptoms. They may become aware of it when they develop a heart condition.

Other signs and symptoms of hyperlipoproteinemia include:

  • Pancreatitis (type 1)
  • Abdominal pain (types 1 and 5)
  • Enlarged liver or spleen (type 1)
  • Lipid deposits or xanthomas (type 1)
  • Family history of heart disease (types 2 and 4)
  • Family history of diabetes (types 4 and 5)
  • Heart attack
  • Stroke

There may be some symptoms not listed above. If you have any concerns about a symptom, please consult your doctor.

When should I see my doctor?

If you or your loved one has any signs or symptoms listed above or you have any questions, please consult with your doctor. Everyone’s body acts differently. It is always best to discuss with your doctor what is best for your situation.


What causes Hyperlipoproteinemia?

Hyperlipoproteinemia can be a primary or secondary condition.

Primary hyperlipoproteinemia is often genetic. It’s a result of a defect or mutation in lipoproteins. These changes result in problems with accumulation of lipids in your body.

Secondary hyperlipoproteinemia is the result of other health conditions that lead to high levels of lipids in your body. These include:

  • Diabetes
  • Hypothyroidism
  • Pancreatitis
  • Use of certain drugs, such as contraceptives and steroids
  • Certain lifestyle choices

Risk factors

What increases my risk for Hyperlipoproteinemia?

You are at higher risk of developing Hyperlipoproteinemia if you are having these conditions:

  • Hypothyroidism
  • Diabetes
  • Pncreatitis

Please consult with your doctor for further information.

Diagnosis & treatment

The information provided is not a substitute for any medical advice. ALWAYS consult with your doctor for more information.

How is Hyperlipoproteinemia diagnosed?

A doctor can diagnose hyperlipoproteinemia with a blood test. Sometimes, family history is useful. If you have lipid deposits on your body, your doctor will also examine those.

Other diagnostic tests might measure thyroid function, glucose, protein in the urine, liver function, and uric acid.

How is Hyperlipoproteinemia treated?

Treatment for hyperlipoproteinemia will depend on which type you have. When the condition is the result of hypothyroidism, diabetes, or pancreatitis, treatment will take the underlying disorder into account.

Your doctor may prescribe medications like the following to help lower lipid levels:

  • Atorvastatin (lipitor)
  • Fluvastatin (lescol xl)
  • Pravastatin (pravachol)
  • Ezetimibe (zetia)

Lifestyle changes & home remedies

What are some lifestyle changes or home remedies that can help me manage Hyperlipoproteinemia?

The following lifestyles and home remedies might help you cope with Hyperlipoproteinemia:

  • A low-fat diet
  • Increased exercise
  • Weight loss
  • Stress relief
  • A decrease in alcohol consumption

If you have any questions, please consult with your doctor to better understand the best solution for you.

Hello Health Group does not provide medical advice, diagnosis or treatment.


Review Date: February 28, 2018 | Last Modified: February 8, 2018

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