Definition

What is Goodpasture syndrome?

Goodpasture syndrome is a rare and potentially life-threatening autoimmune disease. It occurs when your immune system mistakenly attacks the walls of your lungs and the tiny filtering units in your kidneys. The disorder is named after Dr. Ernest Goodpasture, who identified the syndrome in 1919.

Without prompt diagnosis and treatment, the disease can lead to bleeding in your lungs, kidney failure, and even death.

How common is Goodpasture syndrome?

Goodpasture syndrome is a rare autoimmune disorder that appears to affect males more frequently than females. Age of onset is usually between 20 and 30, but individuals at any age may be affected.

Since the disease was first identified in 1919, approximately 600 cases have been noted in the medical literature.

In the US the Anti-GBM disease is an uncommon disorder; approximately 1-2% of all cases of rapidly progressive glomerulonephritis are secondary to this disorder. Please discuss with your doctor for further information.

Symptoms

What are the symptoms of Goodpasture syndrome?

Symptoms may start out slowly, gradually affecting your lungs and then your kidneys. In other cases, they may progress rapidly, becoming severe in a matter of days. Initial symptoms may include:

  • Fatigue, weakness, or lethargy
  • Nausea or vomiting
  • Loss of appetite
  • Unhealthy, pale appearance

If the disease moves to affect your lungs, the following symptoms may occur:

Sometimes symptoms affecting your lungs can become life threatening, particularly if there is a lot of bleeding.

If the disease affects your kidneys, it may cause:

There may be some symptoms not listed above. If you have any concerns about a symptom, please consult your doctor.

When should I see my doctor?

If you or your loved one has any signs or symptoms listed above or you have any questions, please consult with your doctor. Everyone’s body acts differently. It is always best to discuss with your doctor what is best for your situation.

Causes

What causes Goodpasture syndrome?

The exact cause of Goodpasture syndrome is still unknown.

Risk factors

What increases my risk for Goodpasture syndrome?

Certain behaviors and environmental factors are believed to put people at higher risk. Certain respiratory infections may trigger the disease. Exposure to hydrocarbon fumes, metallic dust, tobacco smoke, or certain illegal substances, such as cocaine, may also increase risk.

Scientists believe the immune system attacks lung and kidney tissue because the condition fools your body’s defenses into thinking those parts are foreign to the body itself.

According to the National Kidney Foundation (NKF), Goodpasture syndrome affects men more often than women and occurs most commonly in early adulthood or after the age of 60. The NFK also reports that the disease is more common in Caucasians than in other races. Please consult with your doctor for further information.

Diagnosis & treatment

The information provided is not a substitute for any medical advice. ALWAYS consult with your doctor for more information.

How is Goodpasture syndrome diagnosed?

Your doctor may use several tests to diagnose Goodpasture syndrome. Your doctor will start with a regular physical examination, checking for high blood pressure, bleeding, and abnormal heart and lung sounds. Your doctor will also review your medical history.

Other tests can help determine whether or not you have the disease. A blood test may show the presence of antibodies (proteins produced by your immune system to fight whatever it is that has been identified as a threat) that indicate the presence of the disease. It can also show a high level of waste products, which may indicate kidney problems.

The presence of blood and protein in your urine can be detected through urine testing. These symptoms can also indicate kidney problems.

A chest X-ray may show the presence of abnormal white patches that indicate bleeding in your lungs.

A kidney biopsy may reveal changes that indicate the presence of Goodpasture syndrome. During this test, a sample of tissue from your kidney is removed and sent to a lab for testing. Lab technicians will look for the presence of antibodies or other abnormal cells to help your doctor make a diagnosis.

How is Goodpasture syndrome treated?

Treatments involve medications that slow down your immune system. These may include one or more of the following:

  • Immunosuppressive or cytoxic drugs keep your immune system from making the antibodies that damage your lungs and kidneys (one example is cyclophosphamide)
  • Corticosteroids, such as prednisone, help control bleeding in your lungs

These medications also suppress your immune system.

A treatment called plasmapheresis may be used to help filter out harmful antibodies in your blood. During this procedure, blood is withdrawn, and the liquid portion (plasma) is removed and replaced. The “cleaned” blood is transferred back into your body.

Other treatments depend on your age, overall health, and the severity of the disease. Your doctor may prescribe additional medications to control fluid build-up and high blood pressure. In addition to medication, dietary changes such as cutting down on salt intake can help control swelling and blood pressure.

Lifestyle changes & home remedies

What are some lifestyle changes or home remedies that can help me manage Goodpasture syndrome?

If you have any questions, please consult with your doctor to better understand the best solution for you.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: March 30, 2018 | Last Modified: March 30, 2018

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