What is Gardner syndrome?
Gardner syndrome is an extremely rare genetic pathological condition which is characterized by development of benign growths usually in the colon which over time as the disease condition progresses may cause colon cancer.
The growths caused by Gardner syndrome can occur in any area of the body but are mostly commonly found in the colon. Additionally, the affected individual can have development of fibromas and sebaceous cysts. In some cases, individual can also have lesions in the retina that affects the vision as well due to Gardner syndrome.
How common is Gardner syndrome?
Gardner syndrome is not common. Please discuss with your doctor for further information.
What are the symptoms of Gardner syndrome?
The common symptoms of Gardner syndrome are:
- Abnormal growths in the colon which increase in size and numbers as the condition advances
- Development of extra teeth
- Tumors of the bones in the skull
- Sebaceous cysts
- Development of fibromas
- Pain in the abdominal area as a result of polyps.
There may be some symptoms not listed above. If you have any concerns about a symptom, please consult your doctor.
When should I see my doctor?
If you have any signs or symptoms listed above or have any questions, please consult with your doctor. Everyone’s body acts differently. It is always best to discuss with your doctor what is best for your situation.
What causes Gardner syndrome?
The root cause of Gardner syndrome is a mutation in the APC gene. The function of this gene is to produce APC protein which controls the growth of cells in the body.
A mutation in the APC gene results in malfunction of the APC proteins and the growth of cells becomes abnormal causing the growths seen in Gardner syndrome. There is no clear cause for the mutation in the APC gene seen with Gardner syndrome.
What increases my risk for Gardner syndrome?
Please consult with your doctor for further information.
Diagnosis & treatment
The information provided is not a substitute for any medical advice. ALWAYS consult with your doctor for more information.
How is Gardner syndrome diagnosed?
The diagnosis of Gardner syndrome begins with taking the history of the patient along with a detailed physical examination. A lower GI endoscopy may also be done which will clearly show polyps which may range in hundreds.
When all other causes for the polyps have been ruled out a molecular test may be conducted which will clearly show a mutation in APC gene confirming the diagnosis of Gardner syndrome.
How is Gardner syndrome treated?
Since an individual with a known diagnosis of Gardner syndrome is at risk for developing colon cancer the treatment is basically aimed at preventing this. Regular colon screenings are a necessity for individuals with Gardner syndrome.
If the number of polyps is way too high then a polypectomy may need to be performed to remove the polyps. Medications such as NSAIDs also aid in preventing development of colonic polyps.
In cases of extra teeth as a result of Gardner syndrome, removal of the extra teeth is recommended. Individuals with this condition are recommended to take a balanced diet, avoid spicy foods, and avoid stressful situations so as to cope up with a condition like Gardner syndrome.
Lifestyle changes & home remedies
What are some lifestyle changes or home remedies that can help me manage Gardner syndrome?
If you have any questions, please consult with your doctor to better understand the best solution for you.
Hello Health Group does not provide medical advice, diagnosis or treatment.
Gardner Syndrome: Causes, Symptoms, Treatment, Diagnosis https://www.epainassist.com/genetic-disorders/gardner-syndrome Accessed January 29, 2018
Gardner syndrome https://rarediseases.info.nih.gov/diseases/6482/gardner-syndrome Accessed January 29, 2018
Review Date: January 29, 2018 | Last Modified: January 29, 2018