Factor V deficiency



What is factor V deficiency?

Factor V deficiency is also known as Owren’s disease or parahemophilia. It’s a rare bleeding disorder that results in poor clotting after an injury or surgery. Factor V deficiency shouldn’t be confused with factor V Leiden mutation, a much more common condition that causes excessive blood clotting.

Factor V, or proaccelerin, is a protein made in your liver that helps convert prothrombin into thrombin. This is an important step in the blood clotting process. If you don’t have enough factor V or if it doesn’t work properly, your blood may not clot effectively enough to stop you from bleeding. There are different levels of severity of factor V deficiency based on how little or how much factor V is available to the body.

Factor V deficiency may also occur at the same time as factor VIII deficiency, producing more severe bleeding problems. The combination of factor V and factor VIII deficiencies is considered to be a separate disorder.

How common is factor V deficiency?

Factor V deficiency is not common. This condition occurs in about 1 in 1 million people. Please discuss with your doctor for further information.


What are the symptoms of factor V deficiency?

The symptoms of factor V deficiency vary depending on the amount of factor V available to the body. The levels necessary to cause symptoms depend upon the individual. A certain level that may cause bleeding in one person may not clause bleeding in another person.

In cases of severe factor V deficiency, the symptoms often include:

  • Abnormal bleeding after giving birth, having surgery, or being injured
  • Abnormal bleeding under the skin
  • Umbilical cord bleeding at birth
  • Nosebleeds
  • Bleeding gums
  • Easy bruising
  • Heavy or prolonged menstrual periods
  • Bleeding within organs like the lungs or intestinal tract

There may be some symptoms not listed above. If you have any concerns about a symptom, please consult your doctor.

When should I see my doctor?

If you have any signs or symptoms listed above or have any questions, please consult with your doctor. Everyone’s body acts differently. It is always best to discuss with your doctor what is best for your situation.


What causes factor V deficiency?

Factor V deficiency may be inherited or acquired after birth.

Hereditary factor V deficiency is rare. It’s caused by a recessive gene, which means that you have to inherit the gene from both of your parents in order to show symptoms.

Acquired factor V deficiency may be caused by certain medications, underlying medical conditions, or an autoimmune reaction.

Conditions that might affect factor V include:

  • Disseminated intravascular coagulation (dic), which is a condition that causes small blood clots and excessive bleeding due to overactive clotting proteins
  • Liver diseases, such as cirrhosis
  • Secondary fibrinolysis, which occurs when clots tend to break down due to medications or health conditions
  • Autoimmune diseases, such as lupus
  • Spontaneous autoimmune reactions after surgery or childbirth
  • Certain types of cancer

Risk factors

What increases my risk for factor V deficiency?

Please consult with your doctor for further information.

Diagnosis & treatment

The information provided is not a substitute for any medical advice. ALWAYS consult with your doctor for more information.

How is factor V deficiency diagnosed?

Many people who have this condition received their diagnosis when doctors ran blood coagulation tests before surgery. Common lab tests for factor V include the following:

  • Factor assays measure the performance of specific clotting factors to identify missing or poorly performing factors.
  • Factor V assay measures how much factor V you have and how well it works.
  • Prothrombin time (PT) measures clotting time affected by factors I, II, V, VII, and X.
  • Activated partial prothrombin time (aPTT) measures clotting time affected by factors I, II, V, VIII, IX, X, XI, XII, and von Willebrand factors.
  • Inhibitor tests determine if your immune system is suppressing your blood clotting factors.

How is factor V deficiency treated?

Factor V deficiency is treated with infusions of fresh frozen plasma (FFP) and blood platelets. These infusions are typically needed only after surgery or a bleeding episode.

Lifestyle changes & home remedies

What are some lifestyle changes or home remedies that can help me manage factor V deficiency?

If you have any questions, please consult with your doctor to better understand the best solution for you.

Hello Health Group does not provide medical advice, diagnosis or treatment.


Review Date: January 26, 2018 | Last Modified: January 29, 2018

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