Know the basics

What is Anti-DNA Antibody Test?

Anti-DNA antibody test is useful to diagnose and monitor systemic lupus erythematosus (SLE). Antibodies are found in 65% -80% of patients with SLE and the disease is rarely seen in other diseases. Feature of systemic lupus erythematosus is high concentration of antibody. However, if this antibody concentration is medium to low, it does not mean you suffer from systemic lupus erythematosus disease, because there are many different autoimmune diseases can also increase concentration of antibodies low to moderate levels.

Why is Anti-DNA Antibody Test performed?

Your doctor will specify tests when you have signs and symptoms relating to lupus or you have a positive result for ANA test. Here are some symptoms of SLE:

  • Muscle pain;
  • Moderate fever;
  • Fatigue;
  • Hair loss and weight loss;
  • Skin is very sensitive to light;
  • Pain in joints like arthritis, joint pain and no injuries.
  • Numbness or tingling like needles in hands and feet.

This test is also used to monitor and identify lupus flare up of severe lupus.

Things to know before

What should I know before receiving Anti-DNA Antibody Test?

You should be aware of these factors which may affect the test results:

  • If you’re using radioactive imaging within 1 week before the test, it can affect test results.
  • Drugs may increase concentrations of anti-DNA antibodies and falsifying test results including: hydralazine and procainamide.
  • Sometimes you have positive result if you have other diseases such as chronic hepatitis, liver cirrhosis and primary biliary stasis increased infection mononucleosis.

It is important you understand the warnings and precautions before having this surgery. If you have any questions, please consult with your doctor for more information and instructions.

Know what happens

How to prepare for Anti-DNA Antibody Test?

Your doctor will explain testing procedures for you. Actually, this test is a blood test. You do not need to have any preparation for the test. You also do need stop eating or drinking before testing.

You should wear a short sleeve shirt in order to nurse can easily take blood from your arm.

What happens during Anti-DNA Antibody Test?

  • Bandage around arm to stop bleeding.
  • Disinfect the injection site with alcohol.
  • Inject needle into vein. They could inject more than 1 time if necessary.
  • Attach a hose to contain bleeding.
  • Remove the strips of tape around the arm after getting enough blood.
  • Put bandage or a cotton swab on the injection site.
  • Put urgo on the injection site

Doctor will collect blood into a red cap tube.

What happens after Anti-DNA Antibody Test?

Doctors or nurse will take blood for the test. Your pain degree depends on skills of nurses, your venous situation and your sensitivity to pain.

After a blood draw, you need to put bandage and press lightly on needle puncture to stop bleeding. You can return to normal activity after the test.

If you have any questions about the Anti-DNA antibody test, please consult with your doctor to better understand your instructions.

Understand the results

What do my results mean?

Normal results: Negative: <5 international units / mL

Abnormal result: Neutral 5-9 international units / mL;

  • Positive: ≥10 international units / mL;
  • Increase concentration;:
  • Circuit collagen disease (eg, systemic lupus erythematosus disease);
  • Chronic Hepatitis;
  • Biliary cirrhosis;
  • Infectious mononucleosis.

Depending on the laboratory and hospital, the normal range for Anti-DNA antibody test may vary. Please discuss with your doctor any questions you may have about your test results.

Hello Health Group does not provide medical advice, diagnosis or treatment.


Review Date: January 4, 2017 | Last Modified: January 4, 2017

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