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Definition

What is Achard-Thiers syndrome?

Achard-Thiers syndrome is a rare disorder that occurs primarily in postmenopausal women and is characterized by type 2 (insulin-resistant) diabetes mellitus and signs of androgen excess.

How common is Achard-Thiers syndrome?

Achard-Thiers syndrome is rare. Please discuss with your doctor for further information.

Symptoms

What are the symptoms of Achard-Thiers syndrome?

The common symptoms of Achard-Thiers syndrome are:

  • Onset of diabetes
  • Frequent urination
  • Excessive thirst and hunger
  • Weight loss

The signs and symptoms caused by overproduction of androgens may include:

  • Hirsutism: Development of excess body hair on the face, chest, and back
  • Receding hairline
  • Deepening of the voice
  • Enlargement of the clitoris
  • Infertility
  • Obesity
  • Oligomenorrhea: Infrequent or very light menstrual periods
  • Amenorrhea: Absence of menstrual periods
  • Facial hypertrichosis (excess hair on the face in males)
  • Adrenal cortical hyperplasia or adenoma

There may be some symptoms not listed above. If you have any concerns about a symptom, please consult your doctor.

When should I see my doctor?

If you have any signs or symptoms listed above or have any questions, please consult with your doctor. Everyone’s body acts differently. It is always best to discuss with your doctor what is best for your situation.

Causes

What causes Achard-Thiers syndrome?

Achard-Thiers syndrome appears to be transmitted within families. But the exact mechanism of genetic transmission is not yet understood. The possible contributing factors may include:

  • Diabetes is the main cause for this disorder and this may be due to:
  • Use of certain chemicals and drugs such as thiazide diuretics, adrenal corticosteroids, and hormonal contraceptives
  • Physiological and emotional stress

Risk factors

What increases my risk for Achard-Thiers syndrome?

There are many risk factors for Achard-Thiers syndrome, such as:

  • Postmenopausal women
  • Obese or overweight women

Diagnosis & treatment

The information provided is not a substitute for any medical advice. ALWAYS consult with your doctor for more information.

How is Achard-Thiers syndrome diagnosed?

Achard-Thiers syndrome is diagnosed using the following methods:

  • Complete physical exam with thorough medical history: The diagnosis is based on the symptoms manifested by the condition
  • The disorder can be confirmed by a 2-hour oral glucose tolerance test, which is done to check abnormally elevated glucose levels in blood
  • Blood levels of androgen, estrogen, hemoglobin A1c
  • Complete blood count
  • Thyroid function test
  • Liver function test
  • Ultrasound scan of abdomen
  • CT abdomen

Many clinical conditions may have similar signs and symptoms. Your healthcare provider may perform additional tests to rule out other clinical conditions to arrive at a definitive diagnosis.

How is Achard-Thiers syndrome treated?

The various treatment methods for Achard-Thiers syndrome include:

  • Diabetes may be managed through proper diet or intake of insulin or other related medications such as sulfonylureas, meglitinides, biguanides, alpha-glucosidase inhibitors, and thiazolidinediones
  • Cosmetic measures, such as waxing and electrolysis, may be helpful in removing excess hair
  • Hormone replacement therapy is often prescribed for post-menopausal women with Achard-Thiers syndrome
  • Anti-androgens can also be used to treat symptoms of androgen excess
  • Hormonal therapy to rectify endocrine imbalances caused by systemic diseases may also be considered

Lifestyle changes & home remedies

What are some lifestyle changes or home remedies that can help me manage Achard-Thiers syndrome?

The following lifestyles and home remedies might help you cope with Achard-Thiers syndrome:

  • Maintaining the correct body weight is important
  • Avoiding drugs that may cause diabetes
  • During pregnancy, care should be taken to control glucose levels and ensure proper weight management
  • Reducing cholesterol and triglyceride levels can also be beneficial
  • Reducing smoking will help to avoid complications and prevent heart diseases
  • Dietary education and weight reduction are very important factors in controlling blood pressure and diabetes. These are important contributing factors for Achard-Thiers syndrome
  • Doing regular exercise will help to prevent obesity

If you have any questions, please consult with your doctor to better understand the best solution for you.

Hello Health Group does not provide medical advice, diagnosis or treatment.

Sources

Review Date: September 6, 2017 | Last Modified: September 6, 2017

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