Abercrombies syndrome

By Medically reviewed by hellodoktor


What is Abercrombies syndrome?

Abercrombies syndrome is a condition that occurs when there is infiltration of amyloid between cells and fibers of tissues and organs. Amyloid is a waxy protein containing starch and cellulose. This type of protein cannot be dissolved or broken down. When amyloid penetrates an organ, it will usually become deposited in the connective tissue cells and the capillary walls.

This condition occurs when amyloid permeates the fibers or cells of a tissue and causes degeneration. Abercrombie’s syndrome most commonly occurs in the spleen, kidneys and liver, though it can affect any tissue. As the tissue continues to degenerate, it will lose some or all of its normal functioning. Since the symptoms of Abercrombie disease are often vague, this condition might not be diagnosed until a significant amount of degeneration has occurred.

How common is Abercrombies syndrome?

Abercrombies syndrome is considered to be a rare disorder.

However, it can be managed by reducing your risk factors. Please discuss with your doctor for further information.


What are the symptoms of Abercrombies syndrome?

Organs affected by Abercrombie syndrome will typically become:

  • Enlarged
  • Smooth
  • Hard

The tissue will take on a slightly white or yellow translucent appearance, similar to a bacon rind. Within the tissue, the cortex will also be bloodless. When the blood vessels or muscular overlay of an artery are affected, the tissue will thicken and become transparent. Commonly affected organs include the spleen, kidneys, pancreas and liver. Almost any organ or bodily tissue, however, can become affected by Abercrombie disease.

The signs and symptoms of Abercrombie syndrome vary according to the tissue or organ affected. Since sufferers of this condition are commonly suffering from other wasting diseases, a person’s symptoms might be overlooked. People suffering from Abercrombie syndrome of the kidneys may notice increased urine production, vomiting, diarrhea, bad breath, and edema. Those suffering from degeneration in other organs might notice similar symptoms or even symptoms more specific to the organ’s function.

When should I see my doctor?

Early diagnosis and treatment can stop this condition from worsening and prevent another medical emergency, so talk to your doctor as soon as possible to prevent this serious condition.

If you have any questions, please consulting with your doctor. Everyone’s body acts differently. It is always best to discuss with your doctor what is best for your situation.


What causes Abercrombies syndrome?

The disease is not an independent one but usually comes on in certain cachectic states due to chronic tuberculosis, syphilis, diseases of bone involving prolonged suppuration, chronic dysentery, etc.

As more unusual causes of Abercrombie’s syndrome, may be mentioned leukemia, Hodgkin’s disease (malignant lymphoma), very rarely cancer or sarcoma. It is frequently associated with the kidney with chronic inflammation of that organ, but it is doubtful whether the latter is to be regarded as its cause, for, on the one hand, amyloid disease may lead to nephritis, and, on the other, both conditions may be the result of syphilis.

Risk factors

What increases my risk for Abercrombies syndrome?

You may have higher risks for this condition if you are experiencing these following conditions:

  • Trachoma is said to be an important risk. Researchers suggested nutritional deficiency as a possible cause. Researchers considered amyloid degeneration as a subgroup of hyaline infiltration.

Diagnosis & treatment

The information provided is not a substitute for any medical advice. ALWAYS consult with your doctor for more information.

How is Abercrombies syndrome diagnosed?

If your doctor suspects that you experience Abercrombies syndrome, he/she will perform an exam thoroughly to determine this condition

Then he/she will order some tests such as:

  • The presence of amyloid substance is determined by its physical characters and by certain color tests

The earliest known of this latter is the reaction with iodine. The iodine reaction is useful for roughly testing macroscopically at the time of the post-mortem.

  • For microscopic purposes watery solutions of methylviolet or gentian violet as introduced by Cornil are most suitable

These dyes produce a rose-pink color with the amyloid substance, while normal tissues are stained blue. In testing by iodine microscopically a solution half the strength of that mentioned above is to be used.

  • The substance itself has a peculiar bright translucent glancing appearance, and, as the structures in which it occurs are enlarged, they are often remarkably prominent under the microscope.

How is Abercrombies syndrome treated?

It is believed that the treatment must be directed to the improvement of the blood, and to the rapid elimination of all septic material. The anemia which forms a conspicuous part of this disease must be treated with iron and other direct restoratives in order to facilitate the carrying of oxygen into the blood. The use of one or more of our excellent vegetable alternatives will produce favorable results. Echinacea stands at the head and with this there is phytolacca, polymnia, stillingia, baptisia, corydalis, yellow dock, burdock, and dandelion, with the specific liver remedies. These may be persisted in for weeks at a time with only good results. For their general tonic effect the glycerophosphates, hydrastis and strychnin will be selected.

Lifestyle changes & home remedies

What are some lifestyle changes or home remedies that can help me manage Abercrombies syndrome?

It is believed that patients might also be advised to consume a nutritious diet and get regular exercise to inhibit further degeneration.

If you have any questions, please consult with your doctor to better understand the best solution for you.

Hello Health Group does not provide medical advice, diagnosis or treatment.

msBahasa Malaysia

Review Date: June 26, 2017 | Last Modified: September 13, 2019